{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T06:30:40Z","timestamp":1778999440790,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p>\n                    Streptococcus pneumoniae exhibiting decreased susceptibility to penicillin are isolated with an increasing prevalence\nin Turkey during the last decade. This study was undertaken to investigate the molecular epidemiology\nof non-penicillin-susceptible pneumococci isolated in Ankara, Turkey. Among a population of 246 pneumococci,\n90 pneumococci with penicillin MIC \u2265 0.1\n                    <jats:italic toggle=\"yes\">\u00b5<\/jats:italic>\n                    g\/ml were serotyped, genotyped by pulsed-field gel electrophoresis\n(PFGE), and sequence typed by multilocus sequence typing (MLST). The overall resistance to\npenicillin, cefotaxime, erythromycin, clindamycin, chloramphenicol, tetracycline, rifampicin, ciprofloxacin,\nand vancomycin were 36.6%, 4%, 27.6%, 10.9%, 5.3%, 22.4%, 4.5%, 2%, and 0, respectively. The most frequent\nserotypes were 14, 23B, 9V, 19F, 19A, and 23F. PFGE types represented 17 genetic clusters. PFGE and\nMLST data revealed that there were isolates identical or closely related to the Spain\n                    <jats:sup>9V<\/jats:sup>\n                    -3 ST 156 clone, Portugal\n                    <jats:sup>19F<\/jats:sup>\n                    -\n21 ST 177 clone, and Spain\n                    <jats:sup>23F<\/jats:sup>\n                    -1 ST81 clone. Eleven serotype 14 isolates with emerging resistance to\npenicillin belonged to the ST 230 complex, a predominantly susceptible clone. Serotype 19A, 19F, and 7F variants\nof the ST 230 clone were also identified in the study population. Eight serotype 23B isolates with a new\nST 1349 (18-13-8-6-3-6-8) created another clone with no relation to the currently defined international clones.\nAlthough the pandemic clones Spain\n                    <jats:sup>9V<\/jats:sup>\n                    -3, Portugal1\n                    <jats:sup>9F<\/jats:sup>\n                    -21, and Spain\n                    <jats:sup>23F<\/jats:sup>\n                    -1 are present in our region, the emergence\nof a new 23B clone with a unique ST and the emergence of resistance in the ST230 clone, has presumably\ncontributed to the increase in the prevalence of drug-resistant pneumococci in Turkey.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2006.12.109","type":"journal-article","created":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T15:42:43Z","timestamp":1153323763000},"page":"109-114","source":"Crossref","is-referenced-by-count":9,"title":["Genomic Backgrounds of Drug-Resistant Streptococcus pneumoniae in Ankara, Turkey: Identification of Emerging New Clones"],"prefix":"10.1177","volume":"12","author":[{"given":"B.","family":"Sener","sequence":"first","affiliation":[{"name":"Department of Microbiology and Clinical Microbiology, Hacettepe University Medical Faculty, Sihhiye, 06100, Ankara, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"McGee","sequence":"additional","affiliation":[{"name":"Department of Global Health, Emory University, Atlanta, Georgia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Pinar","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Clinical Microbiology, Hacettepe University Medical Faculty, Sihhiye, 06100, Ankara, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Eser","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Clinical Microbiology, Hacettepe University Medical Faculty, Sihhiye, 06100, Ankara, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,6]]},"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2006.12.109","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2006.12.109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:23:23Z","timestamp":1777667003000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/mdr.2006.12.109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1089\/mdr.2006.12.109"],"URL":"https:\/\/doi.org\/10.1089\/mdr.2006.12.109","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6]]}}}