{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:22:26Z","timestamp":1777922546269,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p>\n                    Nontypeable (NT)\n                    <jats:italic toggle=\"yes\">Streptococcus pneumoniae<\/jats:italic>\n                    strains isolated from eyes were examined for both penicillin susceptibility\nby E-test and penicillin-binding protein (PBP) gene alterations using PCR. Of the 25 ophthalmic\nisolates, 15 proved to be sensitive (PSSP, MIC\u2264 0.06\n                    <jats:italic toggle=\"yes\">\u00b5<\/jats:italic>\n                    g\/ml) and 10 were shown as intermediately resistant\nto penicillin (PISP, MIC = 0.1\u20131\n                    <jats:italic toggle=\"yes\">\u00b5<\/jats:italic>\n                    g\/ml). No penicillin-resistant\n                    <jats:italic toggle=\"yes\">S. pneumoniae<\/jats:italic>\n                    (PRSP, MIC\u2265 2\n                    <jats:italic toggle=\"yes\">\u00b5<\/jats:italic>\n                    g\/ml) were\nfound. PBP gene (\n                    <jats:italic toggle=\"yes\">pbp1a<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">pbp2b<\/jats:italic>\n                    ) alteration PCR indicated that 12 (80.0%) of the 15 ophthalmic PSSPs\nhad unaltered\n                    <jats:italic toggle=\"yes\">pbp<\/jats:italic>\n                    genes and that 3 (20.0%) had alterations in either\n                    <jats:italic toggle=\"yes\">pbp1a<\/jats:italic>\n                    or\n                    <jats:italic toggle=\"yes\">pbp2b<\/jats:italic>\n                    , whereas 8 (80.0%) of\nthe 10 PISPs had unaltered\n                    <jats:italic toggle=\"yes\">pbp<\/jats:italic>\n                    genes and 2 (20.0%) had alterations in both\n                    <jats:italic toggle=\"yes\">pbp1a<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">pbp2b<\/jats:italic>\n                    . These data\nsuggest that penicillin resistance is spread among NT pneumococci typically associated with ophthalmic infections.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2006.12.199","type":"journal-article","created":{"date-parts":[[2006,9,26]],"date-time":"2006-09-26T10:30:33Z","timestamp":1159266633000},"page":"199-202","source":"Crossref","is-referenced-by-count":1,"title":["Penicillin Susceptibility of Non-serotypeable\n                    <i>Streptococcus pneumoniae<\/i>\n                    from Ophthalmic Specimens"],"prefix":"10.1177","volume":"12","author":[{"given":"Fumiko","family":"Kojima","sequence":"first","affiliation":[{"name":"Infectious Diseases Laboratory, Department of Health Sciences, School of Medicine, Kyushu University, Fukuoka, 812-8582, Japan."},{"name":"Department of Biomedical Informatics, Division of Health Science, Osaka University Graduate School of Medicine, Osaka, 565-0871, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Nakagami","sequence":"additional","affiliation":[{"name":"Infectious Diseases Laboratory, Department of Health Sciences, School of Medicine, Kyushu University, Fukuoka, 812-8582, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Takemori","sequence":"additional","affiliation":[{"name":"CRC, Inc., Fukuoka, 813-0062, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Iwatani","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, Division of Health Science, Osaka University Graduate School of Medicine, Osaka, 565-0871, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Infectious Diseases Laboratory, Department of Health Sciences, School of Medicine, Kyushu University, Fukuoka, 812-8582, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,9]]},"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2006.12.199","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2006.12.199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:23:31Z","timestamp":1777667011000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/mdr.2006.12.199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1089\/mdr.2006.12.199"],"URL":"https:\/\/doi.org\/10.1089\/mdr.2006.12.199","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}