{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:22:38Z","timestamp":1777922558778,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2006,6]]},"abstract":"\n The aim of this study was to search for plasmid-encoded quinolone resistance determinants QnrA and QnrS in\nfluoroquinolone-resistant and extended-spectrum\n \u03b2<\/jats:italic>\n -lactamase (ESBL)-producing enterobacterial isolates recovered\nin Sydney, Australia, in 2002. Twenty-three fluoroquinolone-resistant, of which 16 were also ESBL-positive,\nenterobacterial and nonrelated isolates were studied. PCR with primers specific for\n qnrA<\/jats:italic>\n and\n qnrS<\/jats:italic>\n genes and\nprimers specific for a series of ESBL genes were used. A\n qnrA<\/jats:italic>\n gene was identified in two ESBL-positive isolates,\nwhereas no\n qnrS<\/jats:italic>\n -positive strain was found. The QnrA1 determinant was identified in an\n Enterobacter cloacae<\/jats:italic>\n isolate\nand in a carbapenem-resistant Klebsiella pneumoniae isolate, both of which expressed the same ESBL SHV-\n12. Whereas no plasmid was identified in the\n E. cloacae<\/jats:italic>\n isolate,\n K. pneumoniae<\/jats:italic>\n K149 possessed two conjugative\nplasmids, one that harbored the\n qnrA<\/jats:italic>\n and\n bla<\/jats:italic>\n SHV<\/jats:sub>\n -12 genes whereas the other expressed the carbapenemase gene\n bla<\/jats:italic>\n IMP-4<\/jats:sub>\n . The\n qnrA<\/jats:italic>\n gene, was located in both cases downstream of the\n orf513<\/jats:italic>\n recombinase gene and upstream of\nthe\n qnrA1<\/jats:italic>\n gene, a structure identical to that found in\n sul1<\/jats:italic>\n -type integron In36 and\n qnrA<\/jats:italic>\n -positive strains from\nShanghai, China. However, the gene cassettes of the\n sul1<\/jats:italic>\n -type integrons were different. This study identified the\nfirst plasmid-mediated quinolone resistance determinant in Enterobacteriaceae in Australia.\n <\/jats:p>","DOI":"10.1089\/mdr.2006.12.99","type":"journal-article","created":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T15:42:43Z","timestamp":1153323763000},"page":"99-102","source":"Crossref","is-referenced-by-count":26,"title":["Plasmid-Mediated Quinolone Resistance in Australia"],"prefix":"10.1177","volume":"12","author":[{"given":"Jose-Manuel","family":"Rodriguez-Martinez","sequence":"first","affiliation":[{"name":"Service de Bact\u00e9riologie-Virologie, H\u00f4pital de Bic\u00eatre, Assistance Publique\/H\u00f4pitaux de Paris, Facult\u00e9 de M\u00e9decine Paris-Sud, Universit\u00e9 Paris XI, K.-Bic\u00eatre, France."},{"name":"University Hospital Virgen Macarena, University of Sevilla, Sevilla, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Poirel","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie-Virologie, H\u00f4pital de Bic\u00eatre, Assistance Publique\/H\u00f4pitaux de Paris, Facult\u00e9 de M\u00e9decine Paris-Sud, Universit\u00e9 Paris XI, K.-Bic\u00eatre, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvaro","family":"Pascual","sequence":"additional","affiliation":[{"name":"University Hospital Virgen Macarena, University of Sevilla, Sevilla, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrice","family":"Nordmann","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie-Virologie, H\u00f4pital de Bic\u00eatre, Assistance Publique\/H\u00f4pitaux de Paris, Facult\u00e9 de M\u00e9decine Paris-Sud, Universit\u00e9 Paris XI, K.-Bic\u00eatre, France."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,6]]},"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2006.12.99","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2006.12.99","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:23:45Z","timestamp":1777667025000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/mdr.2006.12.99"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1089\/mdr.2006.12.99"],"URL":"https:\/\/doi.org\/10.1089\/mdr.2006.12.99","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6]]}}}