{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:22:40Z","timestamp":1777922560085,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>\n                    Nosocomial outbreaks caused by multidrug-resistant (MDR)\n                    <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                    have been associated to fibrocystic patients and isolates harboring metallo-\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -lactamase (MBL) genes. Genotyping is an important tool for interpreting bacterial nosocomial outbreaks and implementing adequate control strategies. The aim of this study was to evaluate whether an outbreak of MDR\n                    <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                    occurring in different hospitals was due to a unique clone or independent isolates. From 2000 to 2003, 108\n                    <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                    were recovered from colonized\/infected inpatients in hospitals of S\u00e3o Lu\u00eds, Maranh\u00e3o, Brazil. The susceptibility test was performed with antipseudomonal drugs, and the presence of MBL genes were verified by PCR. Isolates were genotyped by pulsed-field gel electrophoresis (PFGE). The majority of strains was multiresistant including a great number presenting the colistin-only-sensitive (COS) profile. PFGE analysis revealed 54 genotypes, with predominance of three major COS clones (A, C, and E) coexisting at different moments and hospitals. Clone A harbored the\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>SPM<\/jats:sub>\n                    gene. Eight unique genotypes also had the COS profile. Other eight MDR genotypes presented isolates with differences in resistance profiles. Here we detected, for the first time, the coexistence of COS\n                    <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                    genotypes disseminated in several hospitals during long periods, attacking patients under various clinical conditions.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2007.708","type":"journal-article","created":{"date-parts":[[2007,7,25]],"date-time":"2007-07-25T09:17:41Z","timestamp":1185355061000},"page":"142-146","source":"Crossref","is-referenced-by-count":16,"title":["Coexistence of Epidemic Colistin-Only-Sensitive Clones of\n                    <i>Pseudomonas aeruginosa<\/i>\n                    , Including the\n                    <i>bla<\/i>\n                    <sub>SPM<\/sub>\n                    Clone, Spread in Hospitals in a Brazilian Amazon City"],"prefix":"10.1177","volume":"13","author":[{"given":"Ros\u00e2ngela","family":"Cipriano","sequence":"first","affiliation":[{"name":"Department of Genetics, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil."},{"name":"Federal University of Maranh\u00e3o (UFMA), Maranh\u00e3o, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f4nica V.","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Health Quality Control National Institute (INCQS), FIOCRUZ, Rio de Janeiro, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9rica L.","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Department of Genetics, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karine","family":"Rangel","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Health Quality Control National Institute (INCQS), FIOCRUZ, Rio de Janeiro, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda S.","family":"Freitas","sequence":"additional","affiliation":[{"name":"Department of Genetics, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina P.","family":"Vicente","sequence":"additional","affiliation":[{"name":"Department of Genetics, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,6]]},"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2007.708","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2007.708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:23:59Z","timestamp":1777667039000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/mdr.2007.708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1089\/mdr.2007.708"],"URL":"https:\/\/doi.org\/10.1089\/mdr.2007.708","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}