{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:09:39Z","timestamp":1790784579951,"version":"4.1.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Enterobacter cloacae<\/jats:italic>\n                    strains are still infrequently resistant to carbapenems. A carbapenem-resistant clinical isolate of\n                    <jats:italic toggle=\"yes\">E. cloacae<\/jats:italic>\n                    producing a plasmid-mediated metallo-\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -lactamase (MBL), VIM-4, was recovered from a Greek hospitalized patient. The\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>VIM-4<\/jats:sub>\n                    gene was located in the variable array of a class 1 integron structure repeatedly detected among\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>VIM-1<\/jats:sub>\n                    -bearing Gram-negative pathogens in Greece. The isolate possessed also on the same conjugative plasmid an extended-spectrum\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -lactamase (ESBL), SHV-2a, which contributed to the\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    -lactam-resistant phenotype. This is the first report showing co-transfer of an ESBL with a VIM-type MBL. It suggests also that different VIM-type gene cassettes have been incorporated in a common integron structure, which seems indigenous of Gram-negative pathogens in our region.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2007.768","type":"journal-article","created":{"date-parts":[[2008,1,9]],"date-time":"2008-01-09T08:19:06Z","timestamp":1199866746000},"page":"221-226","source":"Crossref","is-referenced-by-count":13,"title":["Emergence of Carbapenem-Resistant\n                    <i>Enterobacter cloacae<\/i>\n                    Carrying VIM-4 Metallo-\n                    <i>\u03b2<\/i>\n                    -Lactamase and SHV-2a Extended-Spectrum\n                    <i>\u03b2<\/i>\n                    -Lactamase in a Conjugative Plasmid"],"prefix":"10.1177","volume":"13","author":[{"given":"Alexandros","family":"Ikonomidis","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, University of Thessalia, 412 22 Larissa, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Spanakis","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, University of Athens, 115 27 Athens, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aggeliki","family":"Poulou","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Serres General Hospital, Serres, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyros","family":"Pournaras","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University of Thessalia, 412 22 Larissa, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fani","family":"Markou","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Serres General Hospital, Serres, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanassios","family":"Tsakris","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, University of Athens, 115 27 Athens, Greece."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,12]]},"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2007.768","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2007.768","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:24:20Z","timestamp":1777667060000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/mdr.2007.768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1089\/mdr.2007.768"],"URL":"https:\/\/doi.org\/10.1089\/mdr.2007.768","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}