{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T09:14:29Z","timestamp":1787994869008,"version":"build-2784847793"},"reference-count":0,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2008,9]]},"abstract":"\n Oxacillin resistance was present in 99 of 277 (36%) consecutive\n Staphylococcus aureus<\/jats:italic>\n isolates collected from hospital patients in Tehran during a 15-month period (January 2004\u2013March 2005). The majority of isolates (77\/99 = 78%) had been cultured from wounds or blood. The staphylococcal cassette chromosome\n mec<\/jats:italic>\n (SCC\n mec<\/jats:italic>\n ) types and antimicrobial susceptibility patterns of 99 methicillin-resistant\n S. aureus<\/jats:italic>\n (MRSA) strains were determined. Disk diffusion and agar dilution methods were used to determine the susceptibility of isolates to antimicrobial agents as instructed by Clinical and Laboratory Standards Institute. The presence of\n mecA<\/jats:italic>\n and SCC\n mec<\/jats:italic>\n types was determined by PCR and multiplex PCR. All MRSA isolates were susceptible to vancomycin (MIC90 \u2264 2 \u03bcg\/ml), teicoplanin (MIC90 \u2264 2 \u03bcg\/ml), linezolid, and tigecycline. SCC\n mec<\/jats:italic>\n types III, IIIA, and IV were detected in 87%, 11%, and 2% of isolates, respectively. Isolates belonging to SCC\n mec<\/jats:italic>\n types III and IIIA were multiresistant; in addition to \u03b2-lactam resistance, at least 95% of them were also resistant to kanamycin, erythromycin, tetracycline, azithromycin, gentamicin, and ciprofloxacin. These data indicate that SCC\n mec<\/jats:italic>\n type III MRSA isolates frequently infect patients in a university hospital in Tehran. Susceptibility of MRSA isolates to linezolid and tigecycline suggests that these drugs could play an important role in the treatment of infections caused by these multiresistant pathogens.\n <\/jats:p>","DOI":"10.1089\/mdr.2008.0822","type":"journal-article","created":{"date-parts":[[2008,8,11]],"date-time":"2008-08-11T15:19:27Z","timestamp":1218467967000},"page":"217-220","source":"Crossref","is-referenced-by-count":59,"title":["Staphylococcal Cassette Chromosome\n mec<\/i>\n (SCC\n mec<\/i>\n ) Analysis and Antimicrobial Susceptibility Patterns of Methicillin-Resistant\n Staphylococcus aureus<\/i>\n (MRSA) Isolates in Tehran, Iran"],"prefix":"10.1177","volume":"14","author":[{"given":"Bahram","family":"Fatholahzadeh","sequence":"first","affiliation":[{"name":"Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Emaneini","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwendolyn","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases and Microbiology\u2013Public Health (CIDM\u2013PH), Institute of Clinical Pathology and Medical Research (ICPMR), Westmead Hospital, Sydney West Area Health Service (SWAHS), Westmead, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edet","family":"Udo","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzieh","family":"Aligholi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad H.","family":"Modarressi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keramat","family":"Nouri","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Sedaghat","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad M.","family":"Feizabadi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,9]]},"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2008.0822","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2008.0822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:24:47Z","timestamp":1777667087000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/mdr.2008.0822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["10.1089\/mdr.2008.0822"],"URL":"https:\/\/doi.org\/10.1089\/mdr.2008.0822","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}