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After reevaluation with new breakpoints, resistance rates decreased from 6.1% to 0.5% for nonmeningitis and increased from 6.6% to 33.3% for meningitis isolates in our hospital. This breakpoint modification is expected to reduce the inconsistency between susceptibility results and therapeutic outcomes; however, both the clinical microbiology laboratories and the clinicians should be aware of the change to interpret the susceptibility results.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2009.0084","type":"journal-article","created":{"date-parts":[[2009,11,16]],"date-time":"2009-11-16T13:12:44Z","timestamp":1258377164000},"page":"39-41","source":"Crossref","is-referenced-by-count":4,"title":["Effect of New Breakpoints Proposed by Clinical and Laboratory Standards Institute in 2008 for Evaluating Penicillin Resistance of\n                    <i>Streptococcus pneumoniae<\/i>\n                    in a Turkish University Hospital"],"prefix":"10.1177","volume":"16","author":[{"given":"\u00d6zlem","family":"Do\u011fan","sequence":"first","affiliation":[{"name":"Hacettepe University","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolunay","family":"G\u00fclmez","sequence":"additional","affiliation":[{"name":"Hacettepe University","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcl\u015fen","family":"Has\u00e7elik","sequence":"additional","affiliation":[{"name":"Hacettepe University","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,3]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1086\/499596","article-title":"Does penicillin remain the drug of choice for pneumococcal pneumonia in view of emerging in vitro resistance?","volume":"42","author":"Chiou C.C.","year":"2006","unstructured":"Chiou C.C. 2006. Does penicillin remain the drug of choice for pneumococcal pneumonia in view of emerging in vitro resistance? Clin. Infect. Dis., 42:234\u2013237.","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_3_3_2","volume-title":"Development of in vitro Susceptibility Testing Criteria and Quality Control Parameters. Approved Guideline","author":"[CLSI] Clinical and Laboratory Standards Institute","year":"2008","unstructured":"[CLSI] Clinical and Laboratory Standards Institute. 2008. Development of in vitro Susceptibility Testing Criteria and Quality Control Parameters. Approved Guideline, 3rd. Document M23-A3. Clinical and Laboratory Standards Institute: Wayne, PA.","edition":"3"},{"key":"e_1_3_3_4_2","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing, 18th Informational Supplement M100-S18","author":"[CLSI] Clinical and Laboratory Standards Institute","year":"2008","unstructured":"[CLSI] Clinical and Laboratory Standards Institute. 2008. 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