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Intermittent drug therapy due to noncompliance or poor delivery of therapy promotes the emergence of bacterial strains showing resistance to multiple drugs and the rise of extremely drug-resistant strains. Moreover, increased antibiotic resistance has been observed for several microorganisms, including extremely drug-resistant tuberculosis, vancomycin-resistant\n                    <jats:italic toggle=\"yes\">Enterococcus faecalis<\/jats:italic>\n                    , or methicillin-resistant\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    .\n                    <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                    , cathelicidin induction results in enhanced mycobacterial clearance, and synthetic human neutrophil peptides had a rather modest bactericidal effect in\n                    <jats:italic toggle=\"yes\">Mycobacterium tuberculosis<\/jats:italic>\n                    -infected mice.\n                    <jats:italic toggle=\"yes\">In vivo<\/jats:italic>\n                    therapeutic efficacy of improved molecules that show enhanced bactericidal action\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    remains to be tested.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2009.0087","type":"journal-article","created":{"date-parts":[[2009,11,16]],"date-time":"2009-11-16T13:18:48Z","timestamp":1258377528000},"page":"1-7","source":"Crossref","is-referenced-by-count":3,"title":["Global Reemergence of Tuberculosis: Are Host Defense Peptides an Option to Ameliorate Disease Burden?"],"prefix":"10.1177","volume":"16","author":[{"given":"Mario Alberto","family":"Flores-Valdez","sequence":"first","affiliation":[{"name":"Biomedical Biotechnology, Center for Research and Assistance in Technology and Design of the State of Jalisco, A.C., Guadalajara, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sidharth","family":"Chopra","sequence":"additional","affiliation":[{"name":"SRI International"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,3]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1106753"},{"key":"e_1_3_3_3_2","first-page":"27","article-title":"Immunomodulatory properties of defensins and cathelicidins","volume":"306","author":"Bowdish D.M.","year":"2006","unstructured":"Bowdish D.M., , Davidson D.J., , Hancock R.E. 2006. 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