{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:24:10Z","timestamp":1791307450723,"version":"4.3.1"},"reference-count":48,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:p>\n                    One hundred extended-spectrum \u03b2-lactamase (ESBL)-producing Enterobacteriaceae were recovered from the intensive care unit and the urology ward of the University Hospital of Sahloul in Tunisia between May 2005 and May 2006. The majority of strains showed a high level of resistance to cefotaxime and ceftazidime. Double-disk synergy test and E-test strips were used to confirm production of ESBLs. The molecular analysis revealed that the majority of strains (91%) carried genes encoding CTX-M-15. SHV-12 and SHV-2a were produced, respectively, by 9% and 3% of the strains. Pulsed-field gel electrophoresis of ESBL-producing\n                    <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                    isolates revealed four different clonal groups and three for\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    , showing the absence of spread of any epidemic clone. The CTX-M-15 ESBL-producing\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    of the major clonal group belong to the B2 phylogenetic group, to the sequence type 131, and has a high virulence potential. In conclusion, CTX-M-15 ESBLs accounted for the overwhelming majority of ESBL types among Enterobacteriaceae from our hospital. This study confirms the high rate of ESBLs in Tunisia and further demonstrates the worldwide spread of genes coding for CTX-M-15 enzymes in clinical isolates.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2009.0108","type":"journal-article","created":{"date-parts":[[2010,5,3]],"date-time":"2010-05-03T15:40:25Z","timestamp":1272901225000},"page":"163-170","source":"Crossref","is-referenced-by-count":41,"title":["Characterization and Molecular Epidemiology of Extended-Spectrum \u03b2-Lactamases in Clinical Isolates of Enterobacteriaceae in a Tunisian University Hospital"],"prefix":"10.1177","volume":"16","author":[{"given":"Safia","family":"Dahmen","sequence":"first","affiliation":[{"name":"University Hospital of Sahloul","place":["Tunisia"]},{"name":"University of Medicine Pierre and Marie-Curie","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia","family":"Bettaieb","sequence":"additional","affiliation":[{"name":"University Hospital of Sahloul","place":["Tunisia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wejden","family":"Mansour","sequence":"additional","affiliation":[{"name":"University Hospital of Sahloul","place":["Tunisia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noureddine","family":"Boujaafar","sequence":"additional","affiliation":[{"name":"University Hospital of Sahloul","place":["Tunisia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olfa","family":"Bouall\u00e8gue","sequence":"additional","affiliation":[{"name":"University Hospital of Sahloul","place":["Tunisia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Arlet","sequence":"additional","affiliation":[{"name":"University of Medicine Pierre and Marie-Curie","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,6]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"237","article-title":"Plasmid mediated extended spectrum \u03b2-lactamase (CTX-M-3) from India and gene association with insertion ISEcpI","volume":"201","author":"Amel K.","year":"2001","unstructured":"Amel K., , Poirel L., , Nagarajan S., , Nordmann P. 2001. 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