{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:23:08Z","timestamp":1777922588419,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p>\n                    We describe an outbreak of multidrug-resistant\n                    <jats:italic toggle=\"yes\">Acinetobacter baumannii<\/jats:italic>\n                    producing OXA-66 carbapenemase and resistant to imipenem. We analyze the relationship between the spread of this strain and patient movements within the hospital. Thirty-one isolates of\n                    <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                    recovered from December 21, 2006, to February 18, 2007, were studied. Enterobacterial repetitive intergenic consensus PCR and randomly amplified polymorphic DNA genotyping methods were used to define clusters of clonally related isolates. Pulsed-field gel electrophoresis was used to confirm the results and to check the maintenance of the epidemic strain over the following year. Antibiotic susceptibility testing was performed by microdilution and\n                    <jats:italic toggle=\"yes\">E<\/jats:italic>\n                    -test. The isolates were screened by PCR analysis with primers specific for carbapenemase genes. With the exception of colistin (0%) there were no antibiotics with good activity against these isolates. The epidemiology study revealed that the same strain was responsible for all the infections. This strain appeared to carry the\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA-66<\/jats:sub>\n                    gene. IS\n                    <jats:italic toggle=\"yes\">Aba<\/jats:italic>\n                    1 was present upstream the oxacillinase gene. The clone responsible for the outbreak is still present in hospital.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2009.0113","type":"journal-article","created":{"date-parts":[[2010,6,7]],"date-time":"2010-06-07T08:37:44Z","timestamp":1275899864000},"page":"309-315","source":"Crossref","is-referenced-by-count":13,"title":["Outbreak of\n                    <i>Acinetobacter baumannii<\/i>\n                    Producing OXA-66 in a Spanish Hospital: Epidemiology and Study of Patient Movements"],"prefix":"10.1177","volume":"16","author":[{"given":"Esther","family":"Culebras","sequence":"first","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernado","family":"Gonz\u00e1lez-Romo","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Head","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gracia","family":"Morales","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan J.","family":"Picazo","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1128\/AAC.45.2.583-588.2001","article-title":"Characterization of OXA-25, OXA-26, and OXA-27, molecular class D beta-lactamases associated with carbapenem resistance in clinical isolates of Acinetobacter baumannii","volume":"45","author":"Afzal-Shah M.","year":"2001","unstructured":"Afzal-Shah M., , Woodford N., , Livermore D.M. 2001. Characterization of OXA-25, OXA-26, and OXA-27, molecular class D beta-lactamases associated with carbapenem resistance in clinical isolates of Acinetobacter baumannii. Antimicrob. Agents Chemother, 45:583\u2013588.","journal-title":"Antimicrob. Agents Chemother"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1053\/jhin.2002.1300","article-title":"Environmental contamination during a carbapenem-resistant Acinetobacter baumannii outbreak in an intensive care unit","volume":"52","author":"Aygun G.","year":"2002","unstructured":"Aygun G., , Demirkiran O., , Utku T., , Mete B., , Urkmez S., , Yilmaz M., , Yasar H., , Dikmen Y., , Ozturk R. 2002. Environmental contamination during a carbapenem-resistant Acinetobacter baumannii outbreak in an intensive care unit. J. Hosp. Infect., 52:259\u2013262.","journal-title":"J. Hosp. Infect."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.6.1556-1561.2000"},{"key":"e_1_3_3_5_2","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1469-0691.2005.01096.x","article-title":"The sequences of seven class D beta-lactamases isolated from carbapenem-resistant Acinetobacter baumannii from four continents","volume":"11","author":"Brown S.","year":"2005","unstructured":"Brown S., , Amyes S.G. 2005. The sequences of seven class D beta-lactamases isolated from carbapenem-resistant Acinetobacter baumannii from four continents. Clin. Microbiol. Infect., 11:326\u2013329.","journal-title":"Clin. Microbiol. 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CLSI: Wayne, PA."},{"key":"e_1_3_3_8_2","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1128\/AAC.50.2.756-758.2006","article-title":"Occurrence of OXA-58-like carbapenemases in Acinetobacter spp. collected over 10 years in three continents","volume":"50","author":"Coelho J.","year":"2006","unstructured":"Coelho J., , Woodford N., , Afzal-Shah M., , Livermore D. 2006. Occurrence of OXA-58-like carbapenemases in Acinetobacter spp. collected over 10 years in three continents. Antimicrob. Agents Chemother, 50:756\u2013758.","journal-title":"Antimicrob. 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Emergence and spread of carbapenem-resistant strains of Acinetobacter baumannii in a tertiary-care hospital in Poland. Clin. Microbiol. Infect., 13:490\u2013496.","journal-title":"Clin. Microbiol. Infect."},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.3.946-953.2004"},{"key":"e_1_3_3_31_2","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1469-0691.2006.01675.x","article-title":"Molecular epidemiology of a clonal outbreak of multidrug-resistant Acinetobacter baumannii in a university hospital in Italy","volume":"13","author":"Zarrilli R.","year":"2007","unstructured":"Zarrilli R., , Casillo R., , Di Popolo A., , Tripodi M.F., , Bagattini M., , Cuccurullo S., , Crivaro V., , Ragone E., , Mattei A., , Galdieri N., , Triassi M., , Utili R. 2007. Molecular epidemiology of a clonal outbreak of multidrug-resistant Acinetobacter baumannii in a university hospital in Italy. Clin. Microbiol. Infect., 13:481\u2013489.","journal-title":"Clin. 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