{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:23:12Z","timestamp":1777922592013,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:p>\n                    The CTX-M-15 extended spectrum \u03b2-lactamase (ESBL)-producing\n                    <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                    isolates were identified in 36 patients hospitalized from December 2006 to September 2007 in the medical intensive care unit (ICU) of the Bic\u00eatre hospital, South Paris, France. The incidence of colonization and\/or infection was 4.8%. Eighty-nine percent of the ESBL-producing\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    isolates were acquired in the ICU, and only 8.3% of the patients were infected. Pulsed field gel electrophoresis (PFGE) analysis of the isolates showed that 32 isolates were clonally related and contained a 160-kb plasmid carrying the\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CTX-M-15<\/jats:sub>\n                    ,\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA-1<\/jats:sub>\n                    ,\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>TEM-1<\/jats:sub>\n                    , and\n                    <jats:italic toggle=\"yes\">aac6\u2032-Ib-cr<\/jats:italic>\n                    genes. CTX-M-15-producing\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    isolates collected in the ward during the same period of time contained distinct plasmids and were not clonally related. This study highlights the possible occurrence of outbreaks due to CTX-M-producing\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    within hospital settings, whereas CTX-Ms are mostly reported in\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    in community-acquired infections.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2009.0868","type":"journal-article","created":{"date-parts":[[2009,2,20]],"date-time":"2009-02-20T10:11:16Z","timestamp":1235124676000},"page":"47-54","source":"Crossref","is-referenced-by-count":31,"title":["Outbreak of CTX-M-15-Producing\n                    <i>Klebsiella pneumoniae<\/i>\n                    in the Intensive Care Unit of a French Hospital"],"prefix":"10.1177","volume":"15","author":[{"given":"Amelie","family":"Carr\u00ebr","sequence":"first","affiliation":[{"name":"H\u00f4pital de Bic\u00eatre","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludovic","family":"Lassel","sequence":"additional","affiliation":[{"name":"H\u00f4pital de Bic\u00eatre","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Fortineau","sequence":"additional","affiliation":[{"name":"H\u00f4pital de Bic\u00eatre","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meriem","family":"Mansouri","sequence":"additional","affiliation":[{"name":"H\u00f4pital de Bic\u00eatre","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Anguel","sequence":"additional","affiliation":[{"name":"Assistance Publique\/H\u00f4pitaux de Paris","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Richard","sequence":"additional","affiliation":[{"name":"Assistance Publique\/H\u00f4pitaux de Paris","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrice","family":"Nordmann","sequence":"additional","affiliation":[{"name":"H\u00f4pital de Bic\u00eatre","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,3]]},"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2009.0868","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2009.0868","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:25:20Z","timestamp":1777667120000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/mdr.2009.0868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["10.1089\/mdr.2009.0868"],"URL":"https:\/\/doi.org\/10.1089\/mdr.2009.0868","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}