{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:23:15Z","timestamp":1777922595092,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:p>\n                    This study investigated the antimicrobial resistance phenotypes and genotypes among fecal\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    isolates from the members of a single Jordanian family over a 6-month period. A total of 55 (51%)\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    isolates were resistant to &gt;2, and 21 (19%) to &gt;3 of the 14 tested antimicrobial agents, respectively. The highest resistance rates were observed to tetracycline (42%), followed by coamoxyclav and cotrimoxazole (32%), gentamicin (31%), and nalidixic acid (27%). Sixteen out of 21 (76%) multiresistant\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    isolates (resistant to &gt;3 drugs) transferred most of their resistance markers\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    to\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    K12. Five out of the six family members were colonized with\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    carrying one or two of the two common plasmid sizes (54.3 and 13.2\u2009kb). Ten of these isolates (48%) were positive for class 1 integron genes and harbored four\n                    <jats:italic toggle=\"yes\">tet<\/jats:italic>\n                    (A) and five\n                    <jats:italic toggle=\"yes\">tet<\/jats:italic>\n                    (B) genes, respectively, but all were negative for\n                    <jats:italic toggle=\"yes\">tet<\/jats:italic>\n                    (39). The genetic diversity of\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    isolates using randomly amplified polymorphic DNA-PCR demonstrated 13 major clusters of genotype groups, and most of the isolates (63%) belonged to one genotype group. This study indicates that all six family members are colonized with fecal\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    isolates exhibiting a common number of antimicrobial resistance phenotypes and at least one prevalent genotype.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2009.0876","type":"journal-article","created":{"date-parts":[[2009,5,11]],"date-time":"2009-05-11T11:31:48Z","timestamp":1242041508000},"page":"103-107","source":"Crossref","is-referenced-by-count":4,"title":["Common Antimicrobial Resistance Phenotypes and Genotypes of Fecal\n                    <i>Escherichia coli<\/i>\n                    Isolates from a Single Family Over a 6-Month Period"],"prefix":"10.1177","volume":"15","author":[{"given":"Manar R.","family":"Al-Dweik","sequence":"first","affiliation":[{"name":"University of Jordan","place":["Jordan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asem A.","family":"Shehabi","sequence":"additional","affiliation":[{"name":"University of Jordan","place":["Jordan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,6]]},"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2009.0876","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2009.0876","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:25:22Z","timestamp":1777667122000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/mdr.2009.0876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["10.1089\/mdr.2009.0876"],"URL":"https:\/\/doi.org\/10.1089\/mdr.2009.0876","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}