{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:11:33Z","timestamp":1787008293501,"version":"build-2736575974"},"reference-count":20,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:p>\n                    Daptomycin has demonstrated clinical efficacy in the treatment of methicillin-resistant\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    \u2013associated bacteremia and right-sided infective endocarditis. Although daptomycin is not approved for treatment of gram-positive pneumonia, clinical evidence suggests that it may be effective therapy for\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    \u2013associated septic pulmonary emboli (SPE). We present our clinical experience with the use of daptomycin in combination with rifampin in four patients with SPE in the absence of infective endocarditis. Three of the patients had a history of injection drug use; two of these patients also had soft-tissue infections. All patients had clinical resolution of their infections. Daptomycin and rifampin appear to have a role in the treatment of methicillin-resistant\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    bacteremia with SPE in the absence of infective endocarditis and should be considered in patients that have failed therapy with vancomycin.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2010.0001","type":"journal-article","created":{"date-parts":[[2010,7,12]],"date-time":"2010-07-12T06:32:19Z","timestamp":1278916339000},"page":"241-244","source":"Crossref","is-referenced-by-count":15,"title":["Daptomycin and Rifampin for the Treatment of Methicillin-Resistant\n                    <i>Staphylococcus aureus<\/i>\n                    Septic Pulmonary Emboli in the Absence of Endocarditis"],"prefix":"10.1177","volume":"16","author":[{"given":"Eric O.","family":"Gomez","sequence":"first","affiliation":[{"name":"University of Medicine and Dentistry of New Jersey\u2013New Jersey Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmar","family":"Jafary","sequence":"additional","affiliation":[{"name":"University of Medicine and Dentistry of New Jersey\u2013New Jersey Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa L.","family":"Dever","sequence":"additional","affiliation":[{"name":"University of Medicine and Dentistry of New Jersey\u2013New Jersey Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,9]]},"reference":[{"key":"e_1_3_1_2_2","volume-title":"Presented at the 11th International Congress on Infectious Diseases","author":"Alder J.","year":"2004","unstructured":"Alder J., , Arbeit R.D., , Eisenstein B., , Tally F., , Haine H., , Silverman J. 2004. Pulmonary epithelial lining fluid (ELF) as a privileged site: daptomycin in pulmonary infections [abstract 60.005] Presented at the 11th International Congress on Infectious Diseases, Cancun, Mexico."},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/345476"},{"key":"e_1_3_1_4_2","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.hrtlng.2005.05.006","article-title":"Daptomycin cure after cefazolin treatment failure of Methicillin-sensitive Staphylococcus aureus (MSSA) tricuspid valve acute bacterial endocarditis from a peripherally inserted central catheter (PICC) line","volume":"34","author":"Cunha B.A.","year":"2005","unstructured":"Cunha B.A., , Hamid N., , Kessler H., , Parchuri S. 2005. Daptomycin cure after cefazolin treatment failure of Methicillin-sensitive Staphylococcus aureus (MSSA) tricuspid valve acute bacterial endocarditis from a peripherally inserted central catheter (PICC) line. Heart Lung, 34:442\u2013447.","journal-title":"Heart Lung"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa053783"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/49.3.467"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/432475"},{"key":"e_1_3_1_8_2","doi-asserted-by":"crossref","first-page":"5285","DOI":"10.1128\/JCM.43.10.5285-5287.2005","article-title":"Development of Daptomycin resistance in vivo in methicillin-resistant Staphylococcus aureus","volume":"43","author":"Hayden M.K.","year":"2005","unstructured":"Hayden M.K., , Rezai K., , Hayes R.A., , Lolans K., , Quinn J.P., , Weinstein R.A. 2005. Development of Daptomycin resistance in vivo in methicillin-resistant Staphylococcus aureus. J. Clin. Microbiol., 43:5285\u20135287.","journal-title":"J. Clin. Microbiol."},{"key":"e_1_3_1_9_2","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1086\/605690","article-title":"Development of daptomycin-susceptible, methicillin-resistant Staphylococcus aureus pneumonia during high-dose daptomycin therapy","volume":"49","author":"Koplowicz Y.B.","year":"2009","unstructured":"Koplowicz Y.B., , Schwartz B.S., , Guglielmo B.J. 2009. Development of daptomycin-susceptible, methicillin-resistant Staphylococcus aureus pneumonia during high-dose daptomycin therapy. Clin. Infect. Dis., 49:1286\u20131287.","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_1_10_2","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1128\/JCM.02379-07","article-title":"Septic pulmonary emboli and bacteremia associated with deep tissue infections caused by community-acquired methicillin-resistant Staphylococcus aureus","volume":"46","author":"Lin M.Y.","year":"2008","unstructured":"Lin M.Y., , Rezai K., , Schwartz D.N. 2008. Septic pulmonary emboli and bacteremia associated with deep tissue infections caused by community-acquired methicillin-resistant Staphylococcus aureus. J. Clin. Microbiol., 46:1553\u20131555.","journal-title":"J. Clin. Microbiol."},{"key":"e_1_3_1_11_2","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.ijantimicag.2008.07.004","article-title":"Development of multiple lung abscesses during daptomycin treatment for right-sided endocarditis caused by meticillin-resistant Staphylococcus aureus","volume":"32","author":"Liu C.Y.","year":"2008","unstructured":"Liu C.Y., , Wang J.L., , Huang Y.T., , Hsueh P.R. 2008. Development of multiple lung abscesses during daptomycin treatment for right-sided endocarditis caused by meticillin-resistant Staphylococcus aureus. Int. J. Antimicrob. Agents, 32:544\u2013545.","journal-title":"Int. J. Antimicrob. 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Chest, 94:251\u2013253.","journal-title":"Experience at an inner-city hospital. Chest"},{"key":"e_1_3_1_16_2","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1086\/533441","article-title":"Effects of prior effective therapy on the efficacy of daptomycin and ceftriaxone for the treatment of community-acquired pneumonia","volume":"46","author":"Pertel P.E.","year":"2008","unstructured":"Pertel P.E., , Bernardo P., , Fogarty C., , Matthews P., , Northland R., , Benvenuto M., , Thorne G.M., , Luperchio S.A., , Arbeit R.D., , Alder J. 2008. Effects of prior effective therapy on the efficacy of daptomycin and ceftriaxone for the treatment of community-acquired pneumonia. Clin. Infect. Dis., 46:1142\u20131151.","journal-title":"Clin. Infect. 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