{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:23:28Z","timestamp":1777922608367,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:p>\n                    Prevalence of serotype 6B penicillin (PEN)-nonsusceptible\n                    <jats:italic toggle=\"yes\">Streptococcus<\/jats:italic>\n                    <jats:italic toggle=\"yes\">pneumoniae<\/jats:italic>\n                    significantly increased from 15.8% (1993\u20131997) to 67.3% (1998\u20132002) (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001) in Argentina. Serogroup 6 ranks fourth among different capsular types within invasive isolates from Argentinean patients &lt;6 years of age. To evaluate whether the increase in PEN resistance in serotype 6B pneumococci was due to the dissemination of one or more clones, the genetic diversity of 93\n                    <jats:italic toggle=\"yes\">S. pneumoniae<\/jats:italic>\n                    serotype 6B isolates was analyzed. Five BOX-polymerase chain reaction types were obtained (65.5% isolates) and a group of 15 isolates, representing 41.6% of those having a decreased susceptibility to PEN, were further characterized. The antibiotype of these isolates showed their multiresistance, with 100% of the isolates being resistant to erythromycin, 80% to tetracycline, and 73.3% to trimethoprim\u2013sulfamethoxazole. Of the 15 isolates, 13 belonged to the same pulsed-field gel electrophoresis type and\n                    <jats:italic toggle=\"yes\">galU<\/jats:italic>\n                    cluster and were members of the same clone. The identity of the clone was confirmed in four isolates by multilocus sequence typing. The sequence type found (ST315) corresponds to the Poland\n                    <jats:sup>6B<\/jats:sup>\n                    -20 clone. In summary, BOX-polymerase chain reaction, pulsed-field gel electrophoresis, and\n                    <jats:italic toggle=\"yes\">galU<\/jats:italic>\n                    polymorphism were useful tools to detect the presence of a clone whose identity was confirmed by multilocus sequence typing. The isolates belonging to Poland\n                    <jats:sup>6B<\/jats:sup>\n                    -20 found in this work are described for the first time in Latin America.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2010.0027","type":"journal-article","created":{"date-parts":[[2010,12,4]],"date-time":"2010-12-04T13:04:09Z","timestamp":1291467849000},"page":"75-81","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Dissemination of an Erythromycin-Resistant Penicillin-Nonsusceptible\n                    <i>Streptococcus pneumoniae<\/i>\n                    Poland\n                    <sup>6B<\/sup>\n                    -20 Clone in Argentina"],"prefix":"10.1177","volume":"17","author":[{"given":"Laura","family":"Bonofiglio","sequence":"first","affiliation":[{"name":"Universidad de Buenos Aires","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mabel","family":"Regueira","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Enfermedades Infecciosas","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Pace","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Enfermedades Infecciosas","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra","family":"Corso","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Enfermedades Infecciosas","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biol\u00f3gicas and CIBER de Enfermedades Respiratorias, Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Mollerach","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,3]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1003.030252"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.3.1152"},{"key":"e_1_3_3_4_2","first-page":"1353","article-title":"Effects of new penicillin susceptibility breakpoints for Streptococcus pneumoniae United States, 2006\u20132007","volume":"57","author":"Center for Disease Control, Prevention","year":"2008","unstructured":"Center for Disease Control, Prevention. 2008. Effects of new penicillin susceptibility breakpoints for Streptococcus pneumoniae United States, 2006\u20132007. MMWR Morb. Mortal Wkly. Rep., 57:1353\u20131355.","journal-title":"MMWR Morb. Mortal Wkly. Rep."},{"key":"e_1_3_3_5_2","unstructured":"Clinical Laboratory Standards Institute. 2008. Performance Standards for Antimicrobial Susceptibility Testing; Eighteenth Informational Supplement Document M100\u2013S18. Clinical and Laboratory Standards Institute: Wayne PA."},{"key":"e_1_3_3_6_2","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.diagmicrobio.2009.12.009","article-title":"Antimicrobial activity against Streptococcus pneumoniae and Haemophilus influenzae collected globally between 2004 and 2008 as part of the tigecycline evaluation and surveillance trial","volume":"67","author":"Darabi A.","year":"2010","unstructured":"Darabi A., , Hocquet D., , Dowzicky M.J. 2010. Antimicrobial activity against Streptococcus pneumoniae and Haemophilus influenzae collected globally between 2004 and 2008 as part of the tigecycline evaluation and surveillance trial. Diagn. Microbiol. Infect. Dis., 67:78\u201386.","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"e_1_3_3_7_2","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1097\/00006454-200110000-00009","article-title":"Evolution of Streptococcus pneumoniae serotypes and penicillin susceptibility in Latin America, Sireva-Vigia Group, 1993 to 1999","volume":"20","author":"Di Fabio J.L.","year":"2001","unstructured":"Di Fabio J.L., , Castaneda E., , Agudelo C.I., , De La Hoz F., , Hortal M., , Camou T., , Echaniz-Aviles G., , Noemi M., , Barajas C., , Heitmann I., , Hormazabal J.C., , Brandileone M.C., , Dias Vieira V.S., , Regueira M., , Ruvinski R., , Corso A., , Lovgren M., , Talbot J.A., , De Quadros C. 2001. Evolution of Streptococcus pneumoniae serotypes and penicillin susceptibility in Latin America, Sireva-Vigia Group, 1993 to 1999. PAHO Sireva-Vigia Study Group. Pan American Health Organization. Pediatr. Infect. Dis. J., 20:959\u2013967.","journal-title":"Pediatr. Infect. Dis. J."},{"issue":"11","key":"e_1_3_3_8_2","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1099\/00221287-144-11-3049","article-title":"A multilocus sequence typing scheme for Streptococcus pneumoniae: identification of clones associated with serious invasive disease","volume":"144","author":"Enright M.C.","year":"1998","unstructured":"Enright M.C., , Spratt B.G. 1998. A multilocus sequence typing scheme for Streptococcus pneumoniae: identification of clones associated with serious invasive disease. Microbiology, 144,Pt 11:3049\u20133060.","journal-title":"Microbiology"},{"key":"e_1_3_3_9_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S1020-49892008000700001","article-title":"Characterization of invasive isolates of S. pneumoniae, H. influenzae, and N. meningitidis in Latin America and the Caribbean: SIREVA II, 2000\u20132005","volume":"24","author":"Gabastou J.M.","year":"2008","unstructured":"Gabastou J.M., , Agudelo C.I., , Brandileone M.C., , Castaneda E., , de Lemos A.P., , Di Fabio J.L. 2008. Characterization of invasive isolates of S. pneumoniae, H. influenzae, and N. meningitidis in Latin America and the Caribbean: SIREVA II, 2000\u20132005. 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