{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:11:04Z","timestamp":1787008264706,"version":"build-2736575974"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:p>\n                    The study consisted of data for 55,330 U.S.\n                    <jats:italic toggle=\"yes\">Acinetobacter baumannii<\/jats:italic>\n                    isolates from The Surveillance Network\n                    <jats:sup>\u00ae<\/jats:sup>\n                    database for the period 2002\u20132008. Risk factors were time, age, sex, census region, location (Ward or ICU), and isolate source. Antimicrobial susceptibility data were available for carbapenems, cephalosporins, aminoglycosides, fluoroquinolones, and \u03b2-lactam\/\u03b2-lactamase inhibitor combinations. Multiclass resistance was defined as nonsusceptibility to carbapenems and two or more additional classes. Odds of resistance were obtained using a logistic regression model with cubic splines. Carbapenem-associated multiclass resistance has had a 3.7-fold (95% confidence interval [CI] 3.4\u20134.3) increase from 20.6% in 2002 to 49.2% in 2008. Among blood isolates the increase was by 2.2 times (95% CI 1.7\u20132.9). Subjects &lt;18 years old had significantly (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001) lower rates in 2002 (6.9%) than those 65 years or older (21.5%), but by 2008 this difference diminished as rates increased to 44.2% and 54.2%, respectively. A similar divergence was also observed between ICU and Ward, with no differences in 2002, whereas in 2008\u2009ICU isolates had significantly higher rates (55.2%, 95% CI 53.6%\u201356.9%) than Ward isolates (45.6%, 95% CI 44.2%\u201347.0%). Over half of all\n                    <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                    \u2013resistant isolates were carbapenem and multiclass resistant in 2008. Rates among subjects &lt;18 years old have increased faster than those of the elderly, and in the ICU as compared to Ward.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2010.0052","type":"journal-article","created":{"date-parts":[[2010,8,14]],"date-time":"2010-08-14T06:33:52Z","timestamp":1281767632000},"page":"209-215","source":"Crossref","is-referenced-by-count":72,"title":["<i>Acinetobacter baumannii<\/i>\n                    2002\u20132008: Increase of Carbapenem-Associated Multiclass Resistance in the United States"],"prefix":"10.1177","volume":"16","author":[{"given":"Robertino M.","family":"Mera","sequence":"first","affiliation":[{"name":"GlaxoSmithKline"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda A.","family":"Miller","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Amrine-Madsen","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel F.","family":"Sahm","sequence":"additional","affiliation":[{"name":"Eurofins Medinet"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,9]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"127","article-title":"Predictors of mortality in Acinetobacter baumannii bacteremia","volume":"38","author":"Chen H.P.","year":"2005","unstructured":"Chen H.P., , Chen T.L., , Lai C.H., , Fung C.P., , Wong W.W., , Yu K.W., , Liu C.Y. 2005. Predictors of mortality in Acinetobacter baumannii bacteremia. J. Microbiol. Immunol. Infect., 38:127\u2013136.","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2005.00925.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/22.6.1026"},{"key":"e_1_3_3_5_2","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1046\/j.1469-0691.2002.00487.x","article-title":"Nosocomial bacteremia due to Acinetobacter baumannii: epidemiology, clinical features and treatment","volume":"8","author":"Cisneros J.M.","year":"2002","unstructured":"Cisneros J.M., , Rodriguez-Ba\u00f1o J. 2002. Nosocomial bacteremia due to Acinetobacter baumannii: epidemiology, clinical features and treatment. Clin. Microbiol. Infect., 8:687\u201393.","journal-title":"Clin. Microbiol. Infect."},{"key":"e_1_3_3_6_2","unstructured":"[CLSI] Clinical Laboratory Standards Institute. 2008. Performance standards for antimicrobial susceptibility testing; eighteenth informational supplement. CLSI document M100-S18. Wayne PA."},{"key":"e_1_3_3_7_2","first-page":"377","article-title":"Bacteraemia in the adult intensive care unit of a teaching hospital in Nottingham, UK, 1985\u201396","volume":"17","author":"Crowe M.","year":"1998","unstructured":"Crowe M., , Ispahani P., , Humphreys H., , Kelley T., , Winter R. 1998. Bacteraemia in the adult intensive care unit of a teaching hospital in Nottingham, UK, 1985\u201396. Eur. J. Clin. Microbiol. Infect. Dis., 17:377\u2013384.","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"e_1_3_3_8_2","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1086\/505599","article-title":"Attributable mortality of Acinetobacter baumannii infection among critically ill patients","volume":"43","author":"Falagas M.E.","year":"2006","unstructured":"Falagas M.E., , Kopterides P., , Siempos I.I. 2006. Attributable mortality of Acinetobacter baumannii infection among critically ill patients. Clin. Infect. Dis., 43:389.","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_3_9_2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ijantimicag.2005.11.005","article-title":"Potentially multidrug-resistant non-fermentative gram-negative pathogens causing nosocomial pneumonia","volume":"27","author":"Ferrara A.M.","year":"2006","unstructured":"Ferrara A.M. 2006. Potentially multidrug-resistant non-fermentative gram-negative pathogens causing nosocomial pneumonia. Int. J. Antimicrob. Agents., 27:183\u2013195.","journal-title":"Int. J. Antimicrob. 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