{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:34:49Z","timestamp":1791264889164,"version":"4.1.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2011,6]]},"abstract":"\n Of forty-seven extended-spectrum cephalosporin-resistant\n Escherichia coli<\/jats:italic>\n isolates, collected from children at the Children's Hospital in 2006 (Tunis, Tunisia), we analyzed 32 isolates that were genotypically different by enterobacterial repetitive intergenic consensus -polymerase chain reaction. For all isolates, the double-disk diffusion test revealed synergy between clavulanate and cefotaxime and\/or ceftazidime, suggesting the production of extended-spectrum beta-lactamases. Polymerase chain reaction experiments, performed on plasmid DNA, and sequencing revealed the presence of\n bla<\/jats:italic>\n TEM-1B<\/jats:sub>\n (26 isolates, 81%),\n bla<\/jats:italic>\n TEM-34(IRT-6)<\/jats:sub>\n (3 isolates, 9%),\n bla<\/jats:italic>\n SHV-12<\/jats:sub>\n (2 isolates, 6%), and\n bla<\/jats:italic>\n CTX-M-15<\/jats:sub>\n (31 isolates, 97%). Further, the insertion sequence IS\n Ecp1<\/jats:italic>\n was found upstream from the\n bla<\/jats:italic>\n CTX-M-15<\/jats:sub>\n gene in 11 isolates. The\n bla<\/jats:italic>\n genes were found alone or in various combinations in a single isolate.\n bla<\/jats:italic>\n TEM-1B<\/jats:sub>\n and\n bla<\/jats:italic>\n CTX-M-15<\/jats:sub>\n genes were detected in 26 out of the 32 isolates. Three isolates harbored both\n bla<\/jats:italic>\n TEM-34(IRT-6)<\/jats:sub>\n and\n bla<\/jats:italic>\n CTX-M-15<\/jats:sub>\n .\n bla<\/jats:italic>\n SHV-12<\/jats:sub>\n was identified either alone or with\n bla<\/jats:italic>\n CTX-M-15<\/jats:sub>\n in a single isolate. Our investigation showed the dominance of CTX-M-type extended-spectrum beta-lactamases, with CTX-M-15 particularly common, and to our best knowledge, this is the first report of the coexistence of CTX-M-15 and IRT-6 in\n E. coli<\/jats:italic>\n isolates from children in Tunisia.\n <\/jats:p>","DOI":"10.1089\/mdr.2010.0098","type":"journal-article","created":{"date-parts":[[2011,2,3]],"date-time":"2011-02-03T01:06:39Z","timestamp":1296695199000},"page":"135-140","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Emergence and Dominance of CTX-M-15 Extended Spectrum Beta-Lactamase Among\n Escherichia coli<\/i>\n Isolates from Children"],"prefix":"10.1177","volume":"17","author":[{"given":"Samia","family":"R\u00e9jiba","sequence":"first","affiliation":[{"name":"Universit\u00e9 Tunis El-Manar","place":["Tunisia"]},{"name":"H\u00f4pital d'Enfants","place":["Tunisia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola Sandra","family":"Mercuri","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Li\u00e8ge","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Power","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Li\u00e8ge","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amel","family":"Kechrid","sequence":"additional","affiliation":[{"name":"H\u00f4pital d'Enfants","place":["Tunisia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/jac\/dkf151","article-title":"Ceftazidime-hydrolysing CTX-M extended-spectrum beta-lactamase (ESBL) in Poland","volume":"50","author":"Baraniak A.","year":"2002","unstructured":"Baraniak A., , Fiett J., , Hryniewicz W., , Nordmann P., , Gniadkowski M. 2002. 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Evolution of acquired resistance to third-generation cephaloporins in Enterobacteriaceae in Tunisia hospital 1993\u20132001. Clin. Microbial. Infect., 10:665\u2013667.","journal-title":"Clin. Microbial. Infect."},{"key":"e_1_3_3_12_2","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.1128\/AAC.48.10.3758-3764.2004","article-title":"Complete nucleotide sequence of a 92-kilobase plasmide harboring the CTX-M-15 extended-spectrum beta lactamase involved in an outbreak in long-term-care facilities in Toronto, Canada","volume":"48","author":"Boyd D.A.","year":"2004","unstructured":"Boyd D.A., , Tyler S., , Christianson S., , MacGeer A., , Muller M.P., , Willey B.M., , Bryce E., , Gardam M., , Nordmann P., , Mulvey M.R. The Canadian Nosocomial Infection Surveillance Program, Health Canada. 2004. Complete nucleotide sequence of a 92-kilobase plasmide harboring the CTX-M-15 extended-spectrum beta lactamase involved in an outbreak in long-term-care facilities in Toronto, Canada. 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