{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:23:36Z","timestamp":1777922616646,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>\n                    We analyzed the prevalence of resistance to extended-spectrum cephalosporins (ESCs) among clinical strains of\n                    <jats:italic toggle=\"yes\">Salmonella enterica<\/jats:italic>\n                    collected by the Laboratory of Clinical Microbiology in the University Clinical Hospital Lozano Blesa in the region of Arag\u00f3n (Spain), for which very few epidemiological information exists. A total of 2,092 strains of\n                    <jats:italic toggle=\"yes\">S. enterica<\/jats:italic>\n                    were identified in stool samples from patients with gastroenteritis. Five isolates showed an extended-spectrum beta-lactamase (ESBL) phenotype: four isolates of\n                    <jats:italic toggle=\"yes\">S. enterica<\/jats:italic>\n                    serotype Virchow harbored the ESBL-encoding\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CTX-M-9<\/jats:sub>\n                    gene and an isolate of serotype Enteritidis carried a\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CTX-M-1<\/jats:sub>\n                    gene, which, to the best of our knowledge, is described here for the first time in this serotype of\n                    <jats:italic toggle=\"yes\">S. enterica<\/jats:italic>\n                    . The five ESC-resistant isolates were also resistant to spectinomycin, streptomycin, kanamycin, sulfonamides, tetracycline, and trimethoprim as well as to nalidixic acid. The ESBL isolate of serotype Enteritidis, however, remained susceptible to kanamycin and nalidixic acid. A class 1 integron of 1.5\u2009kb was detected for the four serotype Virchow isolates with the gene cassette\n                    <jats:italic toggle=\"yes\">dfrA16<\/jats:italic>\n                    \u2013\n                    <jats:italic toggle=\"yes\">aadA2<\/jats:italic>\n                    . The\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CTX-M-9<\/jats:sub>\n                    gene was carried by an \u223c300-kb IncHI2 conjugative plasmid in the case of the\n                    <jats:italic toggle=\"yes\">S. enterica<\/jats:italic>\n                    serotype Virchow isolates. The\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CTX-M-1<\/jats:sub>\n                    gene was carried by an \u223c100-kb IncI1-N conjugative plasmid for the serotype Enteritidis ESC-resistant isolate. All the four ESC-resistant strains of\n                    <jats:italic toggle=\"yes\">S. enterica<\/jats:italic>\n                    serotype Virchow clustered together in a\n                    <jats:italic toggle=\"yes\">Xba<\/jats:italic>\n                    I pulsed-field gel electrophoresis, which also revealed a strong similarity between them and some pulsotypes of\n                    <jats:italic toggle=\"yes\">S. enterica<\/jats:italic>\n                    serotype Virchow from France.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2010.0105","type":"journal-article","created":{"date-parts":[[2011,1,17]],"date-time":"2011-01-17T00:44:45Z","timestamp":1295225085000},"page":"207-213","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Prevalence and Characterization of Extended-Spectrum Beta-lactamases-Producing\n                    <i>Salmonella enterica<\/i>\n                    Isolates in Saragossa, Spain (2001\u20132008)"],"prefix":"10.1177","volume":"17","author":[{"given":"Mar\u00eda Pardos","family":"de la G\u00e1ndara","sequence":"first","affiliation":[{"name":"Institut Pasteur","place":["France"]},{"name":"Universidad de Zaragoza","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Seral","sequence":"additional","affiliation":[{"name":"Universidad de Zaragoza","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier Castillo","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Universidad de Zaragoza","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen Rubio","family":"Calvo","sequence":"additional","affiliation":[{"name":"Universidad de Zaragoza","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois-Xavier","family":"Weill","sequence":"additional","affiliation":[{"name":"Institut Pasteur","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2005.12.029"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1128\/AAC.40.2.509","article-title":"Sequences of beta-lactamase genes encoding CTX-M-1 (MEN-1) and CTX-M-2 and relationship of their amino acid sequences with those of other beta-lactamases","volume":"40","author":"Bauernfeind A.","year":"1996","unstructured":"Bauernfeind A., , Stemplinger I., , Jungwirth R., , Ernst S., , Casellas J.M. 1996. 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