{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T10:10:34Z","timestamp":1781431834158,"version":"3.54.1"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p>\n                    Historically regarded as a skin commensal,\n                    <jats:italic toggle=\"yes\">Staphylococcus epidermidis<\/jats:italic>\n                    has been increasingly implicated in invasive foreign body infections such as catheter-related bloodstream infections, indwelling device infections, and prosthetic joint infections. We report a case of an aggressive, difficult-to-eradicate, invasive prosthetic hip infection occurring early after hardware implant and associated with a high-grade bacteremia and assess its salient molecular characteristics. The clinical and molecular characteristics of this isolate mirror the pathogenesis and persistence commonly seen with invasive methicillin-resistant\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    and may be attributed to the combination of resistance genes (SCCmec type IV), putative virulence factors (arcA and opp3a), cytolytic peptide production (\u03b1-type phenol-soluble modulins), and biofilm adhesion, interaction, and maturation (bhp, aap, and \u03b2-type phenol-soluble modulins).\n                  <\/jats:p>","DOI":"10.1089\/mdr.2010.0157","type":"journal-article","created":{"date-parts":[[2011,4,21]],"date-time":"2011-04-21T11:13:55Z","timestamp":1303384435000},"page":"345-350","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Molecular Characterization of an Early Invasive\n                    <i>Staphylococcus epidermidis<\/i>\n                    Prosthetic Joint Infection"],"prefix":"10.1177","volume":"17","author":[{"given":"Marnie E.","family":"Rosenthal","sequence":"first","affiliation":[{"name":"Jersey Shore University Medical Center"},{"name":"University of Medicine and Dentistry of New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa L.","family":"Dever","sequence":"additional","affiliation":[{"name":"University of Medicine and Dentistry of New Jersey\u2013New Jersey Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calin S.","family":"Moucha","sequence":"additional","affiliation":[{"name":"Mount Sinai School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalyan D.","family":"Chavda","sequence":"additional","affiliation":[{"name":"University of Medicine and Dentistry of New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Otto","sequence":"additional","affiliation":[{"name":"National Institutes of Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry N.","family":"Kreiswirth","sequence":"additional","affiliation":[{"name":"University of Medicine and Dentistry of New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1097\/00002281-198901020-00011","article-title":"Prosthetic joint infections","volume":"1","author":"Brause B.D.","year":"1989","unstructured":"Brause B.D. 1989. Prosthetic joint infections. Curr. Opin. Rheumatol., 1:194\u2013198.","journal-title":"Curr. Opin. Rheumatol."},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1128\/JCM.00766-09","article-title":"Multiplex real-time PCR for rapid Staphylococcal cassette chromosome mec typing","volume":"47","author":"Chen L.","year":"2009","unstructured":"Chen L., , Mediavilla J.R., , Oliveira D.C., , Willey B.M., , de Lencastre H., , Kreiswirth B.N. 2009. Multiplex real-time PCR for rapid Staphylococcal cassette chromosome mec typing. J. Clin. Microbiol., 47:3692\u20133706.","journal-title":"J. Clin. 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The arginine catabolic mobile element and staphylococcal chromosomal cassette mec linkage: convergence of virulence and resistance in the USA300 clone of methicillin-resistant Staphylococcus aureus. J Infect Dis, 197:1523\u20131530.","journal-title":"J Infect Dis"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2005.04.017"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.1.285-296.2004"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2005.02.011"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.2.1210-1215.2004"},{"key":"e_1_3_3_13_2","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1128\/JCM.02317-06","article-title":"Use of outer surface protein repeat regions for improved genotyping of Staphylococcus epidermidis","volume":"45","author":"Monk A.B.","year":"2007","unstructured":"Monk A.B., , Archer G.L. 2007. Use of outer surface protein repeat regions for improved genotyping of Staphylococcus epidermidis. J. Clin. Microbiol., 45:730\u2013735.","journal-title":"J. Clin. 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