{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:23:45Z","timestamp":1777922625922,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>\n                    Despite the high prevalence of antimicrobial resistance among\n                    <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                    bacteremia, the clinical consequence of resistance remains unclear. The purpose of this study was to identify predictors of mortality and evaluate the clinical impact of antimicrobial resistance on outcome in\n                    <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                    bacteremia. A retrospective cohort study including patients with\n                    <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                    bacteremia was performed. The risk factors for antimicrobial resistances were evaluated, and the impact of the respective resistances on mortality was assessed. Of 202\n                    <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                    bacteremia cases, the resistance rates to ceftazidime, piperacillin, imipenem, fluoroquinolone, and aminoglycoside were 36.6%, 22.3%, 22.8%, 23.8%, and 17.8%, respectively. A prior use of fluoroquinolones and an indwelling urinary catheter were common risk factors for all types of antimicrobial resistance. The overall 30-day mortality rate was 25.2% (51\/202), and the risk factors for mortality were corticosteroid use, nosocomial acquisition, polymicrobial infection, an increasing Charlson's weighted co-morbidity index, and intensive care unit care (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05). As compared with the susceptible group, ceftazidime-, piperacillin-, or imipenem-resistant groups had a higher mortality (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05). A multivariate analysis showed that resistance to ceftazidime or imipenem remained a significant factor associated with mortality (odds ratio, 2.96; 95% confidential interval, 1.20\u20137.31; and odds ratio, 2.74; 95% confidential interval, 1.02\u20137.31, respectively). Antimicrobial resistance, especially to ceftazidime or imipenem, adversely affected outcome in patients with\n                    <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                    bacteremia.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2010.0170","type":"journal-article","created":{"date-parts":[[2011,3,7]],"date-time":"2011-03-07T18:51:54Z","timestamp":1299523914000},"page":"305-312","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":60,"title":["Risk Factors for Mortality in Patients with\n                    <i>Pseudomonas aeruginosa<\/i>\n                    Bacteremia: Clinical Impact of Antimicrobial Resistance on Outcome"],"prefix":"10.1177","volume":"17","author":[{"given":"Eun-Jeong","family":"Joo","sequence":"first","affiliation":[{"name":"Sungkyunkwan University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheol-In","family":"Kang","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Eun","family":"Ha","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Ji","family":"Kang","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So Yeon","family":"Park","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doo Ryeon","family":"Chung","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyong Ran","family":"Peck","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nam Yong","family":"Lee","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Hoon","family":"Song","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.1.43-48.2006"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2004.03.021"},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1086\/528867","article-title":"Pandrug resistance (PDR), extensive drug resistance (XDR), and multidrug resistance (MDR) among Gram-negative bacilli: need for international harmonization in terminology","volume":"46","author":"Falagas M.E.","year":"2008","unstructured":"Falagas M.E., , Karageorgopoulos D.E. 2008. Pandrug resistance (PDR), extensive drug resistance (XDR), and multidrug resistance (MDR) among Gram-negative bacilli: need for international harmonization in terminology. Clin. Infect. Dis., 46:1121\u20131122; author reply 1122.","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-137-10-200211190-00007"},{"key":"e_1_3_3_6_2","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.amjmed.2005.11.029","article-title":"Fluoroquinolone-resistant Pseudomonas aeruginosa: assessment of risk factors and clinical impact","volume":"119","author":"Gasink L.B.","year":"2006","unstructured":"Gasink L.B., , Fishman N.O., , Weiner M.G., , Nachamkin I., , Bilker W.B., , Lautenbach E. 2006. Fluoroquinolone-resistant Pseudomonas aeruginosa: assessment of risk factors and clinical impact. Am. J. Med., 119:526.e519\u2013525.","journal-title":"Am. J. 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