{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:23:56Z","timestamp":1777922636120,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>\n                    To investigate apramycin resistance in humans in Korea, a total of 138 human\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    strains confirmed as gentamicin-resistant were collected from Korean Culture Collection Antimicrobial-Resistant Microbes. Apramycin resistance (minimum inhibitory concentrations \u22651,024\u2009\u03bcg\/ml) was observed in 16 (11.6%) of the 138 gentamicin-resistant\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    (GREC) strains. Among the seven different kinds of aminoglycoside resistance genes tested, only four kinds were detected in the apramycin-resistant GREC strains:\n                    <jats:italic toggle=\"yes\">aac (3)-II<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">aac (3)-III<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">aac (3)-IV<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">armA<\/jats:italic>\n                    . The\n                    <jats:italic toggle=\"yes\">aac (3)-IV<\/jats:italic>\n                    gene was found in all apramycin-resistant GREC strains, whereas\n                    <jats:italic toggle=\"yes\">aac(3)-II<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">aac(3)-III<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">armA<\/jats:italic>\n                    genes were detected in 8 (50.0%), 6 (37.5%), and 1 (6.3%) GREC strains resistant to apramycin, respectively. Of 16 apramycin-resistant GREC strains, transfer of apramycin resistance was observed in seven (43.8%), and co-transfer of resistance to other antimicrobials along with apramycin resistance was also found in four strains (25.0%) by broth mating. The results of this study suggest that more prudential use of apramycin in animals is needed.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2011.0052","type":"journal-article","created":{"date-parts":[[2011,9,9]],"date-time":"2011-09-09T19:37:15Z","timestamp":1315597035000},"page":"563-566","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Detection and Characterization of Aparmycin-Resistant\n                    <i>Escherichia coli<\/i>\n                    from Humans in Korea"],"prefix":"10.1177","volume":"17","author":[{"given":"Suk-Kyung","family":"Lim","sequence":"first","affiliation":[{"name":"National Veterinary Research and Quarantine Service"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyang-Mi","family":"Nam","sequence":"additional","affiliation":[{"name":"National Veterinary Research and Quarantine Service"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aeran","family":"Kim","sequence":"additional","affiliation":[{"name":"National Veterinary Research and Quarantine Service"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gum-Chan","family":"Jang","sequence":"additional","affiliation":[{"name":"National Veterinary Research and Quarantine Service"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee-Soo","family":"Lee","sequence":"additional","affiliation":[{"name":"National Veterinary Research and Quarantine Service"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suk-Chan","family":"Jung","sequence":"additional","affiliation":[{"name":"National Veterinary Research and Quarantine Service"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/ajcp\/45.4_ts.493","article-title":"Antibiotic susceptibility testing by a standardized single disk method","volume":"45","author":"Bauer A.W.","year":"1996","unstructured":"Bauer A.W., , Kirby M.M., , Sherris J.C., , Turck M. 1996. Antibiotic susceptibility testing by a standardized single disk method. Am. J. Clin. Pathol., 45:493\u2013496.","journal-title":"Am. J. Clin. Pathol."},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF00327434","article-title":"Genes for gentamicin-(3)-N-acetyltransferases III and IV: I. Nucleotide sequence of the AAC(3)-IV gene and possible involvement of an IS140 element in its expression","volume":"193","author":"Br\u00e4u B.","year":"1984","unstructured":"Br\u00e4u B., , Pilz U., , Piepersberg E. 1984. Genes for gentamicin-(3)-N-acetyltransferases III and IV: I. Nucleotide sequence of the AAC(3)-IV gene and possible involvement of an IS140 element in its expression. Mol. Gen. Genet., 193:179\u2013187.","journal-title":"Mol. Gen. Genet."},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1574-6968.1989.tb03634.x","article-title":"Detection of apramycin resistant Enterobacteriaceae in hospital isolates","volume":"52","author":"Chaslus-Dancla E.","year":"1989","unstructured":"Chaslus-Dancla E., , Glupcznski Y., , Gerbaud G., , Lagorce M., , Lafont J.P., , Courvalin P. 1989. Detection of apramycin resistant Enterobacteriaceae in hospital isolates. FEMS Microbiol. Lett., 52:261\u2013265.","journal-title":"FEMS Microbiol. Lett."},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2010.0641"},{"key":"e_1_3_3_6_2","volume-title":"Performance standards for antimicrobial susceptibility testing, Nineteenth informational supplement","author":"Clinical, Laboratory Standards Institute","year":"2009","unstructured":"Clinical, Laboratory Standards Institute. 2009. Performance standards for antimicrobial susceptibility testing, Nineteenth informational supplement. Wayne, PAM100-S19."},{"key":"e_1_3_3_7_2","unstructured":"Danish Integrated Antimicrobial Resistance Monitoring Research Programme (DANMAP). 2007. Use of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from food animals foods and humans in DenmarkISSN 1600-2032."},{"key":"e_1_3_3_8_2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/1120009X.1990.11739023","article-title":"Resistance to apramycin in two enterobacterial clinical isolates: detection of a 3-N-acetyltransferase IV","volume":"2","author":"G\u00f3mez-Lus R.","year":"1990","unstructured":"G\u00f3mez-Lus R., , Rivera M.J., , G\u00f3mez-Lus M.L., , Gil J., , G\u00f3mez-Lus S., , Castillo J., , Go\u00f1i P., , Madero P., , Rubio M.C. 1990. Resistance to apramycin in two enterobacterial clinical isolates: detection of a 3-N-acetyltransferase IV. J. Chemother., 2:241\u2013243.","journal-title":"J. Chemother."},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki246"},{"key":"e_1_3_3_10_2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1017\/S0950268800051177","article-title":"Apramycin-resistant Escherichia coli isolated from pigs and a stockman","volume":"112","author":"Hunter J.E.","year":"1994","unstructured":"Hunter J.E., , Bennett M., , Hart C.A., , Shelley J.C., , Walton J.R. 1994. Apramycin-resistant Escherichia coli isolated from pigs and a stockman. Epidemiol. Infect., 112:473\u2013480.","journal-title":"Epidemiol. 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