{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:10:50Z","timestamp":1790457050762,"version":"4.1.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>\n                    To define the risk factors and clinical outcomes of community-onset bacteremia caused by extended-spectrum \u03b2-lactamase (ESBL)-producing\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    (ESBLEC), we analyzed 50 consecutive cases of community-onset bacteremia caused by ESBLEC at a secondary hospital in South Korea from 2005 to 2010. Risk factors were assessed by conducting a case-double control study in which cases were compared with (1) control patients with community-onset bacteremia due to non-ESBLEC, and (2) those with community-onset bacteremia not caused by\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    . Clinical outcome was assessed among patients with community-onset\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    bacteremia. Community-onset bacteremia due to ESBLEC accounted for 6.7% of all community-onset\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    bacteremia. In addition, an increasing proportion of ESBLEC among patients without any healthcare risk factors was observed. Comparison with both control groups revealed that the recent use of antibiotics (odds ratio [OR], 4.3; 95% confidence interval [CI], 1.5\u201312.3) was an independent risk factor for ESBL acquisition. Factors influencing the 30-day mortality were a high Acute Physiology and Chronic Health Evaluation (APACHE) II score (OR, 1.5; 95% CI, 1.1\u20132.0) and severe sepsis or septic shock (OR, 26.6; 95% CI, 1.5\u2013470.7) and malignancy (OR, 11.9; 95% CI, 1.1\u2013134.8). Increased mortality was not statistically associated either with ESBL production or with inappropriate empirical therapy. ESBLEC has emerged as a significant cause of community-onset bacteremia in this hospital, suggesting that ESBLEC are widely disseminated in the South Korean community.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2011.0072","type":"journal-article","created":{"date-parts":[[2011,8,29]],"date-time":"2011-08-29T15:17:09Z","timestamp":1314631029000},"page":"537-544","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":46,"title":["Emergence of Extended-Spectrum \u03b2-Lactamase-Producing\n                    <i>Escherichia coli<\/i>\n                    as a Cause of Community-Onset Bacteremia in South Korea: Risk Factors and Clinical Outcomes"],"prefix":"10.1177","volume":"17","author":[{"given":"Sun Hee","family":"Park","sequence":"first","affiliation":[{"name":"The Catholic University of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Mi","family":"Choi","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Gun","family":"Lee","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayoung","family":"Kim","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Hyun","family":"Choi","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Cheol","family":"Kwon","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Hong","family":"Yoo","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1086\/500936","article-title":"Influx of extended-spectrum \u03b2-lactamase-producing Enterobacteriaceae into the hospital","volume":"42","author":"Ben-Ami R.","year":"2006","unstructured":"Ben-Ami R., , Schwaber M.J., , Navon-Venezia S., , Schwartz D., , Giladi M., , Chmelnitsky I., , Leavitt A., , Carmeli Y. 2006. Influx of extended-spectrum \u03b2-lactamase-producing Enterobacteriaceae into the hospital. Clin. Infect. Dis., 42:925\u2013934.","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_3_3_2","first-page":"1644","article-title":"Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis","volume":"101","author":"Bone R.C.","year":"1992","unstructured":"Bone R.C., , Balk R.A., , Cerra F.B., , Dellinger R.P., , Fein A.M., , Knaus W.A., , Schein R.M., , Sibbald W.J. 1992. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP\/SCCM Consensus Conference Committee. American College of Chest Physicians\/Society of Critical Care Medicine. Chest, 101:1644\u20131655.","journal-title":"The ACCP\/SCCM Consensus Conference Committee. American College of Chest Physicians\/Society of Critical Care Medicine. 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