{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:24:03Z","timestamp":1777922643203,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>\n                    Few studies have investigated the clinical features and outcomes for extended-spectrum \u03b2-lactamase (ESBL)-producing\n                    <jats:italic toggle=\"yes\">Enterobacter<\/jats:italic>\n                    spp.,\n                    <jats:italic toggle=\"yes\">Citrobacter<\/jats:italic>\n                    spp.,\n                    <jats:italic toggle=\"yes\">Serratia<\/jats:italic>\n                    spp., and\n                    <jats:italic toggle=\"yes\">Morganella morganii<\/jats:italic>\n                    (ECSM) bloodstream infections. This study was performed to investigate the clinical features and outcomes for ESBL-producing ECSM bloodstream infections. Patients with ECSM bloodstream infection were enrolled from October 2006 to March 2008. Of 124 patients with ECSM bacteremia, 30 cases (24.2%) were ESBL-producing isolates. Immunosuppressive drugs use within 30 days (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.028), indwelling device at the time of bacteremia (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.042) and antibiotics use within 3 months (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.022) were independently associated with ESBL production in multivariate analysis. Overall 30-day mortality rate was 19.4% (24\/124). When the 30-day mortality rate was evaluated, no significant difference was found between the ESBL group (16.6%; 5\/30) and non-ESBL group (20.2%; 19\/94). Hospitalization was longer in the ESBL group than in the non-ESBL group (65.4\u00b192.8 vs. 32.9\u00b137.8 days, respectively;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.007). The recent use of antibiotics (especially broad-spectrum cephalosporins and other \u03b2-lactam antibiotics) was an important risk factor for ESBL among ECSM bacteremia. ESBL production of ECSM isolates was not significantly associated with mortality but ESBL-producing organisms have an important impact on the duration of hospital stay and subsequent medical cost.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2011.0126","type":"journal-article","created":{"date-parts":[[2012,3,12]],"date-time":"2012-03-12T10:09:14Z","timestamp":1331546954000},"page":"446-452","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Clinical Significance of Infections Caused by Extended-Spectrum \u03b2-Lactamase-Producing\n                    <i>Enterobacteriaceae<\/i>\n                    Blood Isolates with Inducible AmpC \u03b2-Lactamase"],"prefix":"10.1177","volume":"18","author":[{"given":"Hae Suk","family":"Cheong","sequence":"first","affiliation":[{"name":"Konkuk University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwan Soo","family":"Ko","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheol-In","family":"Kang","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doo Ryeon","family":"Chung","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyong Ran","family":"Peck","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Hoon","family":"Song","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,8]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1201-9712(00)90061-4"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1128\/AAC.47.12.3989-3993.2003","article-title":"Prevalence of extended-spectrum beta-lactamase-producing Enterobacter cloacae in the Asia-Pacific region: results from the SENTRY Antimicrobial Surveillance Program, 1998 to 2001","volume":"47","author":"Bell J.M.","year":"2003","unstructured":"Bell J.M., , Turnidge J.D., , Jones R.N. 2003. Prevalence of extended-spectrum beta-lactamase-producing Enterobacter cloacae in the Asia-Pacific region: results from the SENTRY Antimicrobial Surveillance Program, 1998 to 2001. Antimicrob. Agents Chemother., 47:3989\u20133993.","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3947\/ic.2010.42.5.280","article-title":"Prevalence of extended-spectrum beta-lactamase among Enterobacteriacae blood isolates with inducible AmpC beta-lactamase","volume":"42","author":"Cheong H.","year":"2010","unstructured":"Cheong H., , Ko K., , Kang C., , Chung D., , Peck K., , Song S. 2010. Prevalence of extended-spectrum beta-lactamase among Enterobacteriacae blood isolates with inducible AmpC beta-lactamase. Infect. Chemother., 42:280\u2013284.","journal-title":"Infect. Chemother."},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s10096-007-0308-2","article-title":"Prevalence, microbiology, and clinical characteristics of extended-spectrum beta-lactamase-producing Enterobacter spp., Serratia marcescens, Citrobacter freundii, and Morganella morganii in Korea","author":"Choi S.H.","year":"2007","unstructured":"Choi S.H., , Lee J.E., , Park S.J., , Kim M.N., , Choo E.J., , Kwak Y.G., , Jeong J.Y., , Woo J.H., , Kim N.J., , Kim Y.S. 2007. Prevalence, microbiology, and clinical characteristics of extended-spectrum beta-lactamase-producing Enterobacter spp., Serratia marcescens, Citrobacter freundii, and Morganella morganii in Korea. Eur. J. Clin. Microbiol. Infect. Dis., 26; 557\u2013561.","journal-title":"Eur. J. Clin. Microbiol. Infect. 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