{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:24:01Z","timestamp":1777922641209,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>\n                    The objectives of this study were to investigate antibiotic resistance in urinary pathogens from Korean patients with uncomplicated acute pyelonephritis (UAPN), and to determine the effect of fluoroquinolone (FQ) resistance on clinical outcome in those patients with UAPN initially treated with FQ. Clinical and microbiologic data for all the APN patients attending 14 hospitals in South Korea in 2008 were collected retrospectively. Urinary pathogens were identified in 719 cases, and\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    was the most common pathogen (661\/719, 91.9%). Antibiotic susceptibilities to several\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    antibiotics were as follows: ciprofloxacin, 84.1%; trimethoprim-sulfamethoxazola (TMP-SMX), 67.2%; and extended-spectrum beta-lactamase-negative, 92.4%. FQ was the most frequent antibiotic prescribed for UAPN (45.3% intravenously and 53.9% by mouth). We compared clinical outcomes and hospital days in patients with FQ-resistant (32) and FQ-sensitive\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    (173) who received FQ as initial empirical therapy. Clinical cure was higher in the FQ-sensitive group (78% vs. 91%,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.027), and hospital days were longer in the FQ-resistant group (9.6\u00b15.5 days vs. 7\u00b13.5 days,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.001). In conclusion, FQ-sensitivity of\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    from UAPN was 84.1%. FQ treatment of UAPN caused by FQ-resistant\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    has a lower cure rate and involves longer hospital stay than FQ treatment of cases caused by FQ-sensitive\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1089\/mdr.2011.0139","type":"journal-article","created":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T11:18:23Z","timestamp":1331205503000},"page":"169-175","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Fluoroquinolone Resistance in Uncomplicated Acute Pyelonephritis: Epidemiology and Clinical Impact"],"prefix":"10.1177","volume":"18","author":[{"given":"Jaehyun","family":"Shin","sequence":"first","affiliation":[{"name":"Rochester General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieun","family":"Kim","sequence":"additional","affiliation":[{"name":"Hanyang University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-Heon","family":"Wie","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Kyun","family":"Cho","sequence":"additional","affiliation":[{"name":"Gacheon University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Kwan","family":"Lim","sequence":"additional","affiliation":[{"name":"Ajou University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Yop","family":"Shin","sequence":"additional","affiliation":[{"name":"Jeju University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon-Sup","family":"Yeom","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Seo","family":"Lee","sequence":"additional","affiliation":[{"name":"Hallym University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Tae","family":"Kwon","sequence":"additional","affiliation":[{"name":"Daegu Fatima Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyuck","family":"Lee","sequence":"additional","affiliation":[{"name":"Donga University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Jin","family":"Cheong","sequence":"additional","affiliation":[{"name":"Korea University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Hee","family":"Park","sequence":"additional","affiliation":[{"name":"Daejeon University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Won","family":"Park","sequence":"additional","affiliation":[{"name":"Korea University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Yeol","family":"Ryu","sequence":"additional","affiliation":[{"name":"Gyemyeong University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moon-Hyun","family":"Chung","sequence":"additional","affiliation":[{"name":"Inha University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunmi","family":"Yoo","sequence":"additional","affiliation":[{"name":"Inje University Haeundae Paik Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunjoo","family":"Pai","sequence":"additional","affiliation":[{"name":"Hanyang University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,4]]},"reference":[{"key":"e_1_3_3_2_2","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing: 15th Informational Supplement: Approved Standard M100-S15","author":"Clinical, Laboratory Standard Institute","year":"2005","unstructured":"Clinical, Laboratory Standard Institute. 2005. Performance Standards for Antimicrobial Susceptibility Testing: 15th Informational Supplement: Approved Standard M100-S15. Clinical and Laboratory Standards Institute: Wayne, PA."},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1128\/AAC.35.9.1849","article-title":"Use of ciprofloxacin versus use of aminoglycosides for therapy of complicated urinary tract infection: prospective, randomized clinical and pharmacokinetic study","volume":"35","author":"Fang G.D.","year":"1991","unstructured":"Fang G.D., , Brennen C., , Wagener M., , Swanson D., , Hilf M., , Zadecky L., , DeVine J., , Yu V.L. 1991. Use of ciprofloxacin versus use of aminoglycosides for therapy of complicated urinary tract infection: prospective, randomized clinical and pharmacokinetic study. Antimicrob. Agents Chemother., 35:1849\u20131855.","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1086\/320880","article-title":"Antimicrobial resistance among uropathogens that cause community-acquired urinary tract infections in women: a nationalwide analysis","volume":"33","author":"Gupta K.","year":"2001","unstructured":"Gupta K., , Sahm D.F., , Mayfield D., , Stamm W.E. 2001. Antimicrobial resistance among uropathogens that cause community-acquired urinary tract infections in women: a nationalwide analysis. Clin. Infect. Dis., 33:89\u201394.","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq257"},{"key":"e_1_3_3_6_2","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0924-8579(03)00238-3","article-title":"Fluoroquinolones and resistance in the treatment of uncomplicated urinary tract infection","volume":"22","author":"Hooton T.M.","year":"2003","unstructured":"Hooton T.M. 2003. Fluoroquinolones and resistance in the treatment of uncomplicated urinary tract infection. Int. J. Antimicrob. Agents, 22:565\u2013572.","journal-title":"Int. J. Antimicrob. Agents"},{"key":"e_1_3_3_7_2","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.amjmed.2008.04.039","article-title":"Emergence of fluoroquinolone resistance in outpatient urinary Escherichia coli","volume":"121","author":"Johnson L.","year":"2008","unstructured":"Johnson L., , Sabel A., , Burman W.J., , Everhart R.M., , Rome M., , MacKenzie T.D., , Rozwadowski J., , Mehler P.S., , Price C.S. 2008. Emergence of fluoroquinolone resistance in outpatient urinary Escherichia coli. Am. J. Med., 121:876\u2013884.","journal-title":"Am. J. 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Chrchill Livingstone Elsevier: Philadelphia, PA, 966\u2013967."},{"key":"e_1_3_3_14_2","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1056\/NEJM197411282912204","article-title":"Serum versus urinary antimicrobial concentrations in cure of urinary-tract infections","volume":"291","author":"Stamey T.A.","year":"1974","unstructured":"Stamey T.A., , Fair W.R., , Timothy M.M., , Millar M.A., , Mihara G., , Lowery Y.C. 1974. Serum versus urinary antimicrobial concentrations in cure of urinary-tract infections. N. Engl. J. Med., 291:1159\u20131163.","journal-title":"N. Engl. J. 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