{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T18:05:15Z","timestamp":1786471515500,"version":"build-2736575974"},"reference-count":44,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>\n                    The emergence of\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    resistant to extended-spectrum cephalosporins (ESCs) is of concern as ESC is often used to treat infections by Gram-negative bacteria. One-hundred and ten\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    strains isolated in 2009\u20132010 from children warded in a Malaysian tertiary hospital were analyzed for their antibiograms, carriage of extended-spectrum beta-lactamase (ESBL) and AmpC genes, possible inclusion of the beta-lactamase genes on an integron platform, and their genetic relatedness. All\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    strains were sensitive to carbapenems. About 46% of strains were multidrug resistant (MDR;\n                    <jats:italic toggle=\"yes\">i.e.<\/jats:italic>\n                    , resistant to \u22653 antibiotic classes) and almost half (45%) were nonsusceptible to ESCs. Among the MDR strains, high resistance rates were observed for ampicillin (98%), tetracycline (75%), and trimethoprim\/sulfamethoxazole (73%). Out of 110 strains,\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>TEM-1<\/jats:sub>\n                    (49.1%),\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CTX-M<\/jats:sub>\n                    (11.8%), and\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CMY-2<\/jats:sub>\n                    (6.4%) were detected. Twenty-one strains were ESBL producers. CTX-M-15 was the predominant CTX-M variant found and this is the first report of a CTX-M-27-producing\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    strain from Malaysia. Majority (3.1%) of the strains harbored class 1 integron-encoded integrases with a predominance of\n                    <jats:italic toggle=\"yes\">aadA<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">dfr<\/jats:italic>\n                    genes within the integron variable region. No gene cassette encoding ESBL genes was found and integrons were not significantly associated with ESBL or non-ESBL producers. Possible clonal expansion was observed for few CTX-M-15-positive strains but the O25-ST131\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    clone known to harbor CTX-M-15 was not detected while CMY-2-positive strains were genetically diverse.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2011.0222","type":"journal-article","created":{"date-parts":[[2012,3,6]],"date-time":"2012-03-06T10:40:46Z","timestamp":1331030446000},"page":"408-416","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Prevalence and Characterization of Multidrug-Resistant and Extended-Spectrum Beta-Lactamase-Producing\n                    <i>Escherichia coli<\/i>\n                    from Pediatric Wards of a Malaysian Hospital"],"prefix":"10.1177","volume":"18","author":[{"given":"Wing Sze","family":"Ho","sequence":"first","affiliation":[{"name":"University of Malaya","place":["Malaysia"]},{"name":"University of Malaya","place":["Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganeswrie","family":"Balan","sequence":"additional","affiliation":[{"name":"Hospital Sultan Aminah Johor Bharu","place":["Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savithiri","family":"Puthucheary","sequence":"additional","affiliation":[{"name":"University of Malaya","place":["Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boon Hong","family":"Kong","sequence":"additional","affiliation":[{"name":"University of Malaya","place":["Malaysia"]},{"name":"University of Malaya","place":["Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"King Ting","family":"Lim","sequence":"additional","affiliation":[{"name":"University of Malaya","place":["Malaysia"]},{"name":"University of Malaya","place":["Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai Kuan","family":"Tan","sequence":"additional","affiliation":[{"name":"University of Malaya","place":["Malaysia"]},{"name":"University of Malaya","place":["Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu Pei","family":"Koh","sequence":"additional","affiliation":[{"name":"University of Malaya","place":["Malaysia"]},{"name":"University of Malaya","place":["Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chew Chieng","family":"Yeo","sequence":"additional","affiliation":[{"name":"Universiti Sultan Zainal Abidin","place":["Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwai Lin","family":"Thong","sequence":"additional","affiliation":[{"name":"University of Malaya","place":["Malaysia"]},{"name":"University of Malaya","place":["Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2006.12.192"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.1.221"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg256"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.1.1-14.2004"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-102209-163504"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001432-200308000-00003"},{"key":"e_1_3_3_8_2","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1093\/jac\/dkp194","article-title":"Rapid detection of the O25b-ST131 clone of Escherichia coli encompassing the CTX-M-15 producing strains","volume":"64","author":"Clermont O.","year":"2009","unstructured":"Clermont O., , Dhanji H., , Upton M., , Gibreel T., , Fox A., , Boyd D., , Mulvey M.R., , Nordmann P., , Ruppe E., , Sarthou J.L., , Frank T., , Vimont S., , Arlet G., , Branger C., , Woodford N., , Denamur E. 2009. Rapid detection of the O25b-ST131 clone of Escherichia coli encompassing the CTX-M-15 producing strains. J. Antimicrob. Chemother., 64:274\u2013277.","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_3_9_2","volume-title":"Seventeenth Informational Supplement. CLSI document M100-S17 (ISBN 1 56238-625-5)","author":"Clinical, Laboratory Standards Institute","year":"2007","unstructured":"Clinical, Laboratory Standards Institute. 2007. Performance standards for antimicrobial susceptibility testing. Seventeenth Informational Supplement. CLSI document M100-S17 (ISBN 1 56238-625-5) CLSI: Wayne, PA."},{"key":"e_1_3_3_10_2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1128\/AAC.49.1.477-478.2005","article-title":"First description of CTX-M-15-producing Klebsiella pneumoniae in Portugal","volume":"49","author":"Conceicao T.","year":"2005","unstructured":"Conceicao T., , Brizio A., , Duarte A., , Lito L.M., , Cristino J.M., , Salgado M.J. 2005. 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