{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:24:24Z","timestamp":1777922664527,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,1,11]],"date-time":"2013-01-11T00:00:00Z","timestamp":1357862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2013,6,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Haemophilus influenzae<\/jats:italic>\n                    frequently colonizes the nasopharynx of children and adults, which can lead to a variety of infections. We investigated\n                    <jats:italic toggle=\"yes\">H. influenzae<\/jats:italic>\n                    carriage in the nasopharynx of 360 children, in terms of (1) the prevalence of strains with decreased susceptibility, and (2) the presence of amino acid substitutions in PBP3. One hundred twenty-three strains were isolated (34.2%, 123\/360), 122 of which were classified as nontypable\n                    <jats:italic toggle=\"yes\">H. influenzae<\/jats:italic>\n                    (NTHi). Of these, \u03b2-lactamase-nonproducing ampicillin-susceptible strains accounted for 26.2%, \u03b2-lactamase-producing-ampicillin-resistant strains for 9.0%, \u03b2-lactamase-nonproducing ampicillin-resistant (BLNAR) strains for 40.2%, and \u03b2-lactamase-producing amoxicillin-\/clavulanic acid-resistant (BLPACR) for 24.6%, respectively. Pulsed field gel electrophoresis (PFGE) patterns were so diverse that they were clustered into 41 groups. The amino acid substitutions in the transpeptidase domain (292 amino acids) of\n                    <jats:italic toggle=\"yes\">ftsI<\/jats:italic>\n                    in BLNAR isolates showed that group IIb accounted for 30.6%, IIc for 8.2%, IId for 16.3%, III for 32.7%, and the others for 12.2%. Moreover, groups IIb (56.7%; 17\/30) and III (23.3%; 7\/30) were prevalent among BLPACR strains. They were subclassified into more diverse sequence subtypes by analysis of the entire PBP3 (610 amino acids). Groups IIb, IIc, IId, and III exhibited 13, four, six, and four sequence subtypes, respectively. Such a genetic diversity is likely indicative of significant potential for decreased antimicrobial susceptibility in nasopharyngeal-colonizing NTHi strains.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2012.0116","type":"journal-article","created":{"date-parts":[[2013,1,11]],"date-time":"2013-01-11T09:35:07Z","timestamp":1357896907000},"page":"224-230","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Genetic Diversity of the\n                    <i>ftsI<\/i>\n                    Gene in \u03b2-Lactamase-Nonproducing Ampicillin-Resistant and \u03b2-Lactamase-Producing Amoxicillin-\/Clavulanic Acid-Resistant Nasopharyngeal\n                    <i>Haemophilus influenzae<\/i>\n                    Strains Isolated from Children in South Korea"],"prefix":"10.1177","volume":"19","author":[{"given":"Chulmin","family":"Park","sequence":"first","affiliation":[{"name":"The Catholic University of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung-Hyo","family":"Kim","sequence":"additional","affiliation":[{"name":"Ewha Womans University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na-Young","family":"Shin","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Hyun","family":"Byun","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun-Young","family":"Kwon","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Wook","family":"Lee","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo Jin","family":"Kwon","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eu Yoon","family":"Choi","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Gun","family":"Lee","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo Yun","family":"Sohn","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Biologicals"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Han","family":"Kang","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,1,11]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00966-09"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq533"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.7.1504"},{"key":"e_1_3_3_5_2","volume-title":"Eighteenth informational supplement","author":"[CLSI] Clinical, Laboratory Standards Institute","year":"2010","unstructured":"[CLSI] Clinical, Laboratory Standards Institute. 2010. 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