{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:24:26Z","timestamp":1777922666940,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T00:00:00Z","timestamp":1357689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2013,6,1]]},"abstract":"<jats:p>\n                    Seventy-one isolates of Enterobacteriaceae (17\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    , 50\n                    <jats:italic toggle=\"yes\">Klebsiella pneumoniae,<\/jats:italic>\n                    and 4\n                    <jats:italic toggle=\"yes\">Enterobacter cloacae<\/jats:italic>\n                    ) producing extended-spectrum-\u03b2-lactamases (ESBLs) were collected between April 2008 and March 2010 in an intensive care unit and surgical ward of Tlemcen Hospital (West of Algeria). Sequencing identified the\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CTX-M-15<\/jats:sub>\n                    determinant in 69 isolates and\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CTX-M-3<\/jats:sub>\n                    in 2 isolates. None of the studied strains produced the class D carbapenemase OXA-48. Repetitive Extragenic palindromic polymerase chain reaction showed a high degree of genotypic diversity among\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    strains and two major clonal populations of\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    (CKp1\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    =11 and CKp5\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    =25) which were further identified as members of the multilocus sequence typing types (ST931) and (ST15), respectively. The ST15 isolates harbored more resistance genes and virulence factors than the ST931 isolates. The characterization of the spacer region between ISE\n                    <jats:italic toggle=\"yes\">cp1<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CTX-M<\/jats:sub>\n                    for CTX-M-15 producers individualized two populations. One that derived from the CTX-M-3 under Algerian clinical context and one that is universally found. The dissemination of ESBLs in the studied Enterobacteriaceae isolates was mainly due to the epidemic clones of\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    and to genetic transit of plasmids among unrelated strains.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2012.0161","type":"journal-article","created":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T15:06:00Z","timestamp":1357743960000},"page":"185-190","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Molecular and Epidemiological Characterization of Enterobacterial Multidrug-Resistant Strains in Tlemcen Hospital (Algeria) (2008\u20132010)"],"prefix":"10.1177","volume":"19","author":[{"given":"Zaket","family":"Baba Ahmed-Kazi Tani","sequence":"first","affiliation":[{"name":"Universit\u00e9 Abou Bekr Belka\u00efd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Decr\u00e9","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Pierre et Marie Curie","place":["France"]},{"name":"H\u00f4pital Saint-Antoine","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Genel","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Pierre et Marie Curie","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahia","family":"Boucherit-Otmani","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Abou Bekr Belka\u00efd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Arlet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Pierre et Marie Curie","place":["France"]},{"name":"H\u00f4pital Tenon","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mourad","family":"Drissi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Abou Bekr Belka\u00efd"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,1,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl242"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.26719\/2012.18.4.382"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05114-11"},{"key":"e_1_3_3_5_2","first-page":"799","article-title":"Plasmid-medited quinolone resistance in expanded spectrum beta-lactamase producing Enterobacteriaceae in Morocco","volume":"12","author":"Bouchakour M.","year":"2010","unstructured":"Bouchakour M., , Zerouali K., , Gros Claude J.-D., , Amarouch H., , El Madaghri N., , Courvalin P., , Timimouni M. 2010. 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