{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:02:45Z","timestamp":1791302565787,"version":"4.1.0"},"reference-count":52,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>\n                    The aim of the study was the characterization of extended spectrum beta-lactamases (ESBLs) and quinolone resistance in cefotaxime-resistant coliform isolates from a wastewater treatment plant (WWTP). ESBLs were detected in 19 out of 24 isolates (79%) from raw water and in 21 out of 24 isolates (87.5%) from treated water, identified as\n                    <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    . Molecular characterization of ESBLs and quinolone resistance showed allele profiles CTX-M-15 (3), CTX-M-3 (5), CTX-M-15+\n                    <jats:italic toggle=\"yes\">qnr<\/jats:italic>\n                    B1 (1), CTX-M-3+\n                    <jats:italic toggle=\"yes\">qnr<\/jats:italic>\n                    B1 (1), CTX-M-15+\n                    <jats:italic toggle=\"yes\">aac-(6\u2032)-Ib-cr<\/jats:italic>\n                    (4), and CTX-M-15+\n                    <jats:italic toggle=\"yes\">qnr<\/jats:italic>\n                    B1+\n                    <jats:italic toggle=\"yes\">aac-(6\u2032)-Ib-cr<\/jats:italic>\n                    (7). A double mutation S83L and D87N (GyrA) and a single mutation S80I (ParC) were detected in ciprofloxacin-resistant\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    isolates. In\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    , mutations S83I (GyrA)+S80I (ParC) or single S80I mutation were detected in ciprofloxacin-resistant isolates, and no mutation was observed in ciprofloxacin-susceptible isolates.\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CTX-M<\/jats:sub>\n                    ,\n                    <jats:italic toggle=\"yes\">qnrB1<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">aac-(6\u2032)-Ib-cr<\/jats:italic>\n                    were found, respectively, in these genetic environments: IS\n                    <jats:italic toggle=\"yes\">Ecp1<\/jats:italic>\n                    -\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CTX-M<\/jats:sub>\n                    -\n                    <jats:italic toggle=\"yes\">orf477<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">orf1005-orf1-qnrB1<\/jats:italic>\n                    , and Tn\n                    <jats:italic toggle=\"yes\">1721<\/jats:italic>\n                    -IS\n                    <jats:italic toggle=\"yes\">26<\/jats:italic>\n                    -\n                    <jats:italic toggle=\"yes\">aac-(6')-Ib-cr<\/jats:italic>\n                    -\n                    <jats:italic toggle=\"yes\">\n                      bla\n                      <jats:sub>OXA-1<\/jats:sub>\n                    <\/jats:italic>\n                    -\n                    <jats:italic toggle=\"yes\">catB4. bla<\/jats:italic>\n                    <jats:sub>CTX-M-15<\/jats:sub>\n                    was located on IncF plasmid in\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CTX-M-3<\/jats:sub>\n                    on IncL\/M plasmid in both species (\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">K. pneumoniae). E. coli<\/jats:italic>\n                    isolates were affiliated to the phylogroups\/MLST: D\/ST405 (CC405), A\/ST10 (CC10), A\/ST617 (CC10), and B1\/ST1431.\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    isolates belonged to phylogroup KpI and to sequence types ST15, ST17, ST36, ST48, ST54, and ST147. The study showed a multi-drug resistance at the inflow and outflow of the WWTP, with ESBL production, plasmid-mediated quinolones resistance, and mutations in topoisomerases. The findings highlight the similarity of antibiotic resistance mechanisms in the clinical setting and the environment, and the role of the latter as a source of dissemination of resistance genes.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2012.0264","type":"journal-article","created":{"date-parts":[[2013,8,17]],"date-time":"2013-08-17T15:05:07Z","timestamp":1376751907000},"page":"30-38","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":67,"title":["Characterization of ESBLs and Associated Quinolone Resistance in\n                    <i>Escherichia coli<\/i>\n                    and\n                    <i>Klebsiella pneumoniae<\/i>\n                    Isolates from an Urban Wastewater Treatment Plant in Algeria"],"prefix":"10.1177","volume":"20","author":[{"given":"Souhila","family":"Alouache","sequence":"first","affiliation":[{"name":"University of Sciences and Technology Houari Boumediene","place":["Algeria"]},{"name":"Campus Universitaire de Dely-Ibrahim","place":["Algeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanesa","family":"Estepa","sequence":"additional","affiliation":[{"name":"Universidad de La Rioja","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamina","family":"Messai","sequence":"additional","affiliation":[{"name":"University of Sciences and Technology Houari Boumediene","place":["Algeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Universidad de La Rioja","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Torres","sequence":"additional","affiliation":[{"name":"Universidad de La Rioja","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabah","family":"Bakour","sequence":"additional","affiliation":[{"name":"University of Sciences and Technology Houari Boumediene","place":["Algeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,2]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1264\/jsme2.ME11266","article-title":"Antibiotic resistance and extended-spectrum \u03b2-Lactamases in Isolated Bacteria from seawater of Algiers beaches (Algeria)","volume":"27","author":"Alouache S.","year":"2012","unstructured":"Alouache S., , Kada M., , Messai Y., , Estepa V., , Torres C., , and Bakour R.. 2012. 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