{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:25:15Z","timestamp":1791080715069,"version":"4.1.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>\n                    This study characterized an IncL\/M-like plasmid containing a\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA-48<\/jats:sub>\n                    -encoding gene from a clinical isolate of\n                    <jats:italic toggle=\"yes\">Klebsiella pneumoniae,<\/jats:italic>\n                    denoted as E71T. Investigation of this plasmid sequence identified unique regions of interest along with conserved regions detected in eight other clinical carbapenem-resistant isolates. A 63-kb plasmid (pE71T) from\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    E71T was sequenced and found to be highly similar to the recently published\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    pOXA-48a (JN626286). Two copies of the insertion sequence element IS\n                    <jats:italic toggle=\"yes\">1R<\/jats:italic>\n                    were identified, one of which was located adjacent to the\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA-48<\/jats:sub>\n                    -encoding gene forming part of a composite transposon Tn\n                    <jats:italic toggle=\"yes\">1999.2<\/jats:italic>\n                    and the second located 16-kb downstream. Plasmid profiling and PCR assays confirmed that the pE71T backbone was conserved among the eight other clinical\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA-48<\/jats:sub>\n                    -positive isolates, and in all cases, the OXA-48 genes were part of the Tn\n                    <jats:italic toggle=\"yes\">1999.2<\/jats:italic>\n                    composite transposon. This is the first report of a\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA-48<\/jats:sub>\n                    and IS\n                    <jats:italic toggle=\"yes\">1R<\/jats:italic>\n                    arrangement-containing plasmid in Ireland.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2013.0022","type":"journal-article","created":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T17:12:29Z","timestamp":1392225149000},"page":"270-274","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Molecular Analysis of OXA-48-Carrying Conjugative IncL\/M-Like Plasmids in Clinical Isolates of\n                    <i>Klebsiella pneumoniae<\/i>\n                    in Ireland"],"prefix":"10.1177","volume":"20","author":[{"given":"Karen","family":"Power","sequence":"first","affiliation":[{"name":"University College Dublin","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[{"name":"University College Dublin","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Karczmarczyk","sequence":"additional","affiliation":[{"name":"University College Dublin","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan","family":"Crowley","sequence":"additional","affiliation":[{"name":"St. James's Hospital","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meaghan","family":"Cotter","sequence":"additional","affiliation":[{"name":"Mater Misericordiae University Hospital","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pippa","family":"Haughton","sequence":"additional","affiliation":[{"name":"University College Dublin","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Lynch","sequence":"additional","affiliation":[{"name":"Mater Misericordiae University Hospital","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Schaffer","sequence":"additional","affiliation":[{"name":"St. Vincent's University Hospital","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9amus","family":"Fanning","sequence":"additional","affiliation":[{"name":"University College Dublin","place":["Ireland"]},{"name":"Queen's University Belfast","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"6506","DOI":"10.1128\/JB.00375-06","article-title":"Functional characterization of IS1999, an IS4 family element involved in mobilization and expression of ?-lactam resistance genes","volume":"188","author":"Aubert D.","year":"2006","unstructured":"Aubert D., , Naas T., , Heritier C., , Poirel L., , and Nordmann P.. 2006. Functional characterization of IS1999, an IS4 family element involved in mobilization and expression of ?-lactam resistance genes. J. Bacteriol., 188:6506\u20136514.","journal-title":"J. Bacteriol."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-9-75"},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.1128\/AAC.02550-12","article-title":"Characterization of a new blaOXA-48-carrying plasmid in Enterobacteriaceae","volume":"57","author":"Berger S.","year":"2013","unstructured":"Berger S., , Alauzet C., , Aissa N., , H\u00e9nard S., , Rabaud C., , Bonnet R., et al. 2013. Characterization of a new blaOXA-48-carrying plasmid in Enterobacteriaceae. Antimicrob. Agents Chemother., 57:4064\u20134067.","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2005.03.018"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01672-07"},{"key":"e_1_3_3_7_2","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1128\/AAC.01452-10","article-title":"Outbreak of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in France","volume":"55","author":"Cuzon G.","year":"2011","unstructured":"Cuzon G., , Ouanich J., , Gondret R., , Naas T., , and Nordmann P.. 2011. Outbreak of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in France. Antimicrob. Agents Chemother., 55:2420\u20132423.","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_3_3_8_2","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1093\/jac\/dks124","article-title":"Characterization of Enterobacteriaceae producing OXA-48-like carbapenemases in the UK","volume":"67","author":"Dimou V.","year":"2012","unstructured":"Dimou V., , Dhanji H., , Pike R., , Livermore D.M., , and Woodford N.. 2012. Characterization of Enterobacteriaceae producing OXA-48-like carbapenemases in the UK. J. Antimicrob. Chemother., 67:1660\u20131665.","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2011.10.005"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00601-11"},{"key":"e_1_3_3_11_2","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1128\/AAC.00638-12","article-title":"Detection of OXA-48 carbapenemase in the pandemic clone Escherichia coli O25b:H4-ST131 in the course of investigation of an outbreak of OXA-48-producing Klebsiella pneumoniae","volume":"56","author":"Morris D.","year":"2012","unstructured":"Morris D., , McGarry E., , Cotter M., , Passet V., , Lynch M., , Ludden C., et al. 2012. Detection of OXA-48 carbapenemase in the pandemic clone Escherichia coli O25b:H4-ST131 in the course of investigation of an outbreak of OXA-48-producing Klebsiella pneumoniae. Antimicrob. Agents Chemother., 56:4030\u20134031.","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_3_3_12_2","article-title":"First isolation and outbreak of OXA-48-producing Klebsiella pneumoniae in an Irish hospital, March to June","volume":"16","author":"O'Brien D.J.","year":"2011","unstructured":"O'Brien D.J., , Wrenn C., , Roche C., , Rose L., , Fenelon C., , Flynn A., et al. 2011. First isolation and outbreak of OXA-48-producing Klebsiella pneumoniae in an Irish hospital, March to June. Euro. Surveill., 16:pii: 19921.","journal-title":"Euro. Surveill."},{"key":"e_1_3_3_13_2","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1128\/AAC.05289-11","article-title":"Genetic features of the widespread plasmid coding for the carbapenemase OXA-48","volume":"56","author":"Poirel L.","year":"2012","unstructured":"Poirel L., , Bonnin R.A., , and Nordmann P.. 2012. Genetic features of the widespread plasmid coding for the carbapenemase OXA-48. Antimicrob. Agents Chemother., 56:559\u2013562.","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_3_3_14_2","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/jac\/dks397","article-title":"A mosaic transposon encoding OXA-48 and CTX-M-15: towards pan-resistance","volume":"68","author":"Potron A.","year":"2013","unstructured":"Potron A., , Nordmann P., , Rondinaud E., , Jaureguy F., , and Poirel L.. 2013. A mosaic transposon encoding OXA-48 and CTX-M-15: towards pan-resistance. J. Antimicrob. Chemother., 68:476\u2013477.","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(10)70004-2"},{"key":"e_1_3_3_16_2","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3389\/fmicb.2013.00188","article-title":"Molecular characterization of blaESBL-harboring conjugative plasmids identified in multi-drug resistant Escherichia coli isolated from food-producing animals and healthy humans","volume":"4","author":"Wang J.","year":"2013","unstructured":"Wang J., , Stephan R., , Karczmarczyk M., , Yan Q., , H\u00e4chler H., , and Fanning S. 2013. Molecular characterization of blaESBL-harboring conjugative plasmids identified in multi-drug resistant Escherichia coli isolated from food-producing animals and healthy humans. Front. Microbiol., 4:188.","journal-title":"Front. Microbiol."},{"key":"e_1_3_3_17_2","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1128\/AEM.00054-13","article-title":"Characteristics of extended-spectrum \u03b2-lactamase- and carbapenemase-producing Enterobacteriaceae Isolates from rivers and lakes in Switzerland","volume":"79","author":"Zurfluh K.","year":"2013","unstructured":"Zurfluh K., , H\u00e4chler H., , N\u00fcesch-Inderbinen M., , and Stephan R.. 2013. Characteristics of extended-spectrum \u03b2-lactamase- and carbapenemase-producing Enterobacteriaceae Isolates from rivers and lakes in Switzerland. Appl. Environ. Microbiol., 79:3021\u20133026.","journal-title":"Appl. Environ. 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