{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:24:45Z","timestamp":1777922685959,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T00:00:00Z","timestamp":1384387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2014,4,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    is a common major cause of bacterial infections in tea tribe patients of the northeast region of Assam, India. In this study, we documented multidrug resistance (MDR) and the prevalence of extended-spectrum \u03b2-lactamases (ESBLs) among 148\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    strains that were isolated from bacterial infections in tea tribe patients who had a history of self-medication. High prevalence of resistance to ampicillin (82%), amoxicillin (68%), cefixime (60%), norfloxacin (60%), nalidixic acid (60%), and co-trimoxazole (53%) was observed. Of 148\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    isolates, 38 (26%) were confirmed as ESBL producers. The ESBL genes were sequenced from highly resistant ESBL producing\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    isolates. Molecular modeling was performed using MODELLER 9v10 software to determine the three-dimensional structure of a protein. This result indicates that the prevailing reason for the high prevalence of antibiotic resistance in this community is prior exposure to low-quality antibiotics, hence MDR in\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    is increasing. ESBLs are enzymes that are produced by resistant bacteria that hydrolyze advanced generations of cephalosporin antibiotics and cause resistance, even in patients with community-acquired infections. So our results provide a framework for understanding the structure and possible binding sites of ESBL proteins for drug targeting, and the results were found to be reliable.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2013.0088","type":"journal-article","created":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T09:41:32Z","timestamp":1384422092000},"page":"170-176","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Prevalence of Extended-Spectrum \u03b2-Lactamase-Producing Multidrug-Resistant\n                    <i>Escherichia coli<\/i>\n                    Among Isolates from Community-Acquired Infections and\n                    <i>In Silico<\/i>\n                    Structural Modeling of an ESBL Protein"],"prefix":"10.1177","volume":"20","author":[{"given":"Krishnamoorthy","family":"Rajapandiyan","sequence":"first","affiliation":[{"name":"Srimad Andavan Arts and Science College","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subbarayan","family":"Shanthi","sequence":"additional","affiliation":[{"name":"Srimad Andavan Arts and Science College","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Periyasamy","family":"Vijayalakshmi","sequence":"additional","affiliation":[{"name":"Holy Cross College","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pitchai","family":"Daisy","sequence":"additional","affiliation":[{"name":"King Saud University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munusamy","family":"Murugan","sequence":"additional","affiliation":[{"name":"King Saud University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amirtham Jacob Appadurai","family":"Ranjitsingh","sequence":"additional","affiliation":[{"name":"Sri Paramakalyani College","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,11,14]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-440X(97)80027-9"},{"key":"e_1_3_3_3_2","unstructured":"Ausubel F.M. Brent R. Kingston R.E. Moore D.D. Seidman J.G. Smith J.A. and Struhl K. editors. 1999. Short Protocols in Molecular Biology 4th ed. Wiley New York."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560021103"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.1.151-159.2002"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/45.4_ts.493"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/326347a0"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.4.933-951.2001"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(69)90487-2"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2006.08.011"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.2.833-835.2005"},{"key":"e_1_3_3_12_2","first-page":"28","article-title":"Current status of drug resistance among gram negative bacilli isolated from admitted cases in a tertiary care centre","volume":"51","author":"Chitnis S.V.","year":"2003","unstructured":"Chitnis S.V., et al. 2003. Current status of drug resistance among gram negative bacilli isolated from admitted cases in a tertiary care centre. J. Assoc. Physicians India, 51:28\u201332.","journal-title":"J. Assoc. Physicians India"},{"key":"e_1_3_3_13_2","first-page":"131","volume-title":"Mackie and McCartney Practical Medical Microbiology","author":"Collee J.G.","year":"1999","unstructured":"Collee J.G., , Miles R.S, , and Watt B.. 1999. Tests for the identification of bacteria. In Collee J.G., , Fraser A.G., , Marmion B.P., , and Simmons A. (eds.), Mackie and McCartney Practical Medical Microbiology. 14th ed., Churchill Livingstone, New York, pp. 131\u2013149.","edition":"14"},{"key":"e_1_3_3_14_2","first-page":"135","volume-title":"Urinary Tract Infections. Molecular Pathogenesis and Clinical Management","author":"Donnenberg M.S.","year":"1996","unstructured":"Donnenberg M.S., , and Welch R.A.. 1996. Virulence determinants of uropathogenic E. coli. In Urinary Tract Infections. Molecular Pathogenesis and Clinical Management. ASM Press, Washington, DC, pp. 135\u2013174."},{"key":"e_1_3_3_15_2","unstructured":"Holt J.G. et al. 1994. Bergey's Manual of Determinative Microbiology. 9th ed.Williams & Wilkins Baltimore."},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471140864.ps0209s50"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/.61.2.136-169.1997"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1110\/ps.062095806"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.9.3045-3049.2002"},{"key":"e_1_3_3_20_2","first-page":"303","article-title":"Antimicrobial resistant Escherichia coli strains isolated from food animals in Pakistan","volume":"43","author":"Idrees M.","year":"2011","unstructured":"Idrees M., et al. 2011. Antimicrobial resistant Escherichia coli strains isolated from food animals in Pakistan. Pakistan J. Zool., 43:303\u2013310.","journal-title":"Pakistan J. Zool."},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/10409239409086797"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1086\/317656"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.8.3533-3537.2005"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btm404"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889892009944"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02065-07"},{"key":"e_1_3_3_27_2","unstructured":"Lennette E.H. et al. 1990. Manual of Clinical Microbiology American Society for Microbiology Washington DC. pp. 10\u201320."},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1086\/598632"},{"key":"e_1_3_3_29_2","first-page":"42","article-title":"Emergence of multidrug resistant strains of Escherichia coli isolated from urinary tract infections","volume":"32","author":"Moniri1 R.","year":"2003","unstructured":"Moniri1 R., , Khorshidi A., , and Akbari H. 2003. Emergence of multidrug resistant strains of Escherichia coli isolated from urinary tract infections. Iran. J. Public Health, 32:42\u201346.","journal-title":"Iran. J. Public Health"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00274-06"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e3283398dc1"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/44.4.489"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001432-200112000-00006"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(08)70041-0"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.12.4038-4040.2002"},{"key":"e_1_3_3_36_2","first-page":"161","article-title":"Diversity of CTX-M \u03b2-lactamases and their promoterregions from Enterobacteriaceae isolated in three Parisian hospitals","volume":"209","author":"Saladin M.","year":"2002","unstructured":"Saladin M., et al. 2002. Diversity of CTX-M \u03b2-lactamases and their promoterregions from Enterobacteriaceae isolated in three Parisian hospitals. FEMS Microbiol. Lett., 209:161\u2013168.","journal-title":"FEMS Microbiol. Lett."},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.2.438-444.2001"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm403"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm290"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1086\/654883"}],"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/mdr.2013.0088","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2013.0088","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2013.0088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:27:56Z","timestamp":1777667276000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/mdr.2013.0088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,14]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4,1]]}},"alternative-id":["10.1089\/mdr.2013.0088"],"URL":"https:\/\/doi.org\/10.1089\/mdr.2013.0088","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,14]]}}}