{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:24:57Z","timestamp":1777922697981,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2014,10]]},"abstract":"\n Contemporary (2012) \u03b2-lactamase-producing isolates (\n n<\/jats:italic>\n =493) from U.S. hospitals were tested against ceftaroline-avibactam.\n Klebsiella<\/jats:italic>\n spp.,\n Escherichia coli<\/jats:italic>\n and\n Proteus mirabilis<\/jats:italic>\n isolates displaying the Clinical and Laboratory Standards Institute (CLSI) screening criteria for extended spectrum \u03b2-lactamase (ESBL) production were evaluated. Isolates carried genes encoding CTX-M (\n n<\/jats:italic>\n =316, CTX-M-14-like and -15-like), KPC (\n n<\/jats:italic>\n =45), CMY-2-like (\n n<\/jats:italic>\n =54), or SHV enzyme with ESBL activity (\n n<\/jats:italic>\n =78). Ceftaroline-avibactam inhibited 98.2% of the isolates at \u22640.5\u2009\u03bcg\/mL, and all strains were inhibited by \u22642\u2009\u03bcg\/mL of this novel \u03b2-lactamase-inhibitor combination. These results confirm that ceftaroline-avibactam could be a useful therapeutic option for Enterobacteriaceae isolates producing \u03b2-lactamases that are prevalent in the United States.\n <\/jats:p>","DOI":"10.1089\/mdr.2013.0181","type":"journal-article","created":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T10:26:39Z","timestamp":1393928799000},"page":"436-440","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Activity of Ceftaroline-Avibactam Tested Against Contemporary Enterobacteriaceae Isolates Carrying \u03b2-Lactamases Prevalent in the United States"],"prefix":"10.1177","volume":"20","author":[{"given":"Mariana","family":"Castanheira","sequence":"first","affiliation":[{"name":"JMI Laboratories"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Williams","sequence":"additional","affiliation":[{"name":"Cerexa, Inc."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald N.","family":"Jones","sequence":"additional","affiliation":[{"name":"JMI Laboratories"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helio S.","family":"Sader","sequence":"additional","affiliation":[{"name":"JMI Laboratories"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir401"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"4779","DOI":"10.1128\/AAC.00817-12","article-title":"Activity of ceftaroline-avibactam tested against gram-negative organism populations, including strains expressing one or more beta-lactamases and methicillin-resistant Staphylococcus aureus carrying various SCCmec types","volume":"56","author":"Castanheira M.","year":"2012","unstructured":"Castanheira M., , Sader H.S., , Farrell D.J., , Mendes R.E., , and Jones R.N.. 2012. Activity of ceftaroline-avibactam tested against gram-negative organism populations, including strains expressing one or more beta-lactamases and methicillin-resistant Staphylococcus aureus carrying various SCCmec types. Antimicrob. Agents Chemother., 56:4779\u20134785.","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1128\/AAC.02252-12","article-title":"Prevalence of \u03b2-lactamase encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 USA hospitals: Report from the SENTRY Antimicrobial Surveillance Program (2010)","volume":"57","author":"Castanheira M.","year":"2013","unstructured":"Castanheira M., , Farrell S.E., , Deshpande L.M., , Mendes R.E., , and Jones R.N.. 2013. Prevalence of \u03b2-lactamase encoding genes among Enterobacteriaceae bacteremia isolates collected in 26 USA hospitals: Report from the SENTRY Antimicrobial Surveillance Program (2010). Antimicrob. Agents Chemother., 57:3012\u20133020.","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_3_3_5_2","unstructured":"[CLSI] Clinical and Laboratory Standards Institute. 2012. M07-A9. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard: ninth edition. Wayne PA: Clinical and Laboratory Standards Institute."},{"key":"e_1_3_3_6_2","unstructured":"[CLSI] Clinical and Laboratory Standards Institute. 2013. M100-S23. Performance standards for antimicrobial susceptibility testing: 23rd informational supplement. Wayne PA: Clinical and Laboratory Standards Institute."},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00037-09"},{"key":"e_1_3_3_8_2","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1128\/AAC.00641-09","article-title":"In vitro activity of NXL104 in combination with \u03b2-lactams against Klebsiella pneumoniae isolates producing KPC carbapenemases","volume":"53","author":"Endimiani A.","year":"2009","unstructured":"Endimiani A., , Choudhary Y., , and Bonomo R.A.. 2009. In vitro activity of NXL104 in combination with \u03b2-lactams against Klebsiella pneumoniae isolates producing KPC carbapenemases. Antimicrob. Agents Chemother., 53:3599\u20133601.","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_3_3_9_2","unstructured":"EUCAST. 2013. Breakpoint tables for interpretation of MICs and zone diameters. Version 3.0 January 2013. Available at www.eucast.org\/clinical_breakpoints\/. 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