{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:25:22Z","timestamp":1777922722546,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>\n                    A total of 92\n                    <jats:italic toggle=\"yes\">Mycobacterium tuberculosis<\/jats:italic>\n                    isolates were collected from patients with pulmonary tuberculosis (TB) in the Zunyi region between 2011 and 2012. Collected isolates were used to determine antibiotic susceptibility patterns against 13 anti-TB drugs: 4 first-line and 9 second-line (ciprofloxacin, gatifloxacin, levofloxacin, moxifloxacin, para-aminosalicylic acid, amikacin, capreomycin, kanamycin, and prothionamide) drugs. Results showed that among 57 new cases of TB only 66.7% were susceptible to all four first-line anti-TB drugs and 64.9% were susceptible to fluoroquinolones and second-line injectables; 10.5% of new and 22.9% of previously treated cases were multidrug-resistant TB (MDR-TB); and 1.8% of new and 2.9% of previously treated cases were extensively drug-resistant TB (XDR-TB). In addition, 14.3% of MDR-TB cases (2 out of 14) were XDR-TB, which is higher than the average numbers in China (about 8%) and in the world (9.6%). This study confirms that primary transmission of drug-resistant TB, including MDR\/XDR-TB, is a real threat to achieving effective control of drug-resistant TB in the Guizhou Province and indicates the necessity to determine antibiotic susceptibility patterns in patients with TB to improve treatment outcomes.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2014.0094","type":"journal-article","created":{"date-parts":[[2015,1,19]],"date-time":"2015-01-19T15:33:51Z","timestamp":1421681631000},"page":"292-296","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Antibiotic Susceptibility Patterns of\n                    <i>Mycobacterium tuberculosis<\/i>\n                    Isolates from Guizhou Province of China Against 13 Antituberculosis Drugs"],"prefix":"10.1177","volume":"21","author":[{"given":"Nana","family":"Li","sequence":"first","affiliation":[{"name":"Affiliated Hospital of Zunyi Medical College","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqin","family":"Liao","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Zunyi Medical College","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Chen","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Zunyi Medical College","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Wang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Zunyi Medical College","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Liu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Zunyi Medical College","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Zunyi Medical College","place":["China"]},{"name":"Z-BioMed, Inc."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1128\/JCM.06095-11","article-title":"Genetic diversity and drug susceptibility of mycobacterium tuberculosis isolates from Zunyi, one of the highest-incidence-rate areas in China","volume":"50","author":"Chen L.","year":"2012","unstructured":"Chen L., , Li N., , Liu Z., , Liu M., , Lv B., , Wang J., , Zhang J., , Wan K., , and Zhang H. 2012. Genetic diversity and drug susceptibility of mycobacterium tuberculosis isolates from Zunyi, one of the highest-incidence-rate areas in China. J. Clin. Microbiol., 50:1043\u20131047.","journal-title":"J. Clin. Microbiol."},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1093\/jac\/dkr319","article-title":"High prevalence of multidrug-resistant tuberculosis in Zunyi, Guizhou Province of China","volume":"66","author":"Chen L.","year":"2011","unstructured":"Chen L., , Li N., , Liu M., , Zhang J., , and Zhang H. 2011. High prevalence of multidrug-resistant tuberculosis in Zunyi, Guizhou Province of China. J. Antimicrob. Chemother., 66:2435\u20132437.","journal-title":"J. Antimicrob. 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PLoS One, 7:e32976.","journal-title":"PLoS One"},{"key":"e_1_3_3_8_2","doi-asserted-by":"crossref","first-page":"510","DOI":"10.3201\/eid1703.101363","article-title":"Increasing drug resistance in extensively drug-resistant tuberculosis, South Africa","volume":"17","author":"Shah N.S.","year":"2011","unstructured":"Shah N.S., , Richardson J., , Moodley P., , Moodley S., , Babaria P., , Ramtahal M., , Heysell S.K., , Li X., , Moll A.P., , Friedland G., , Sturm A.W., , and Gandhi N.R. 2011. Increasing drug resistance in extensively drug-resistant tuberculosis, South Africa. Emerg. Infect. Dis., 17:510\u2013513.","journal-title":"Emerg. Infect. Dis."},{"key":"e_1_3_3_9_2","doi-asserted-by":"crossref","first-page":"368","DOI":"10.7883\/yoken.63.368","article-title":"Prevalence of multidrug and extensively drug-resistant tuberculosis in Beijing, China: a hospital-based retrospective study","volume":"63","author":"Wang D.","year":"2010","unstructured":"Wang D., , Yang C., , Kuang T., , Lei H., , Meng X., , Tong A., , He J., , Jiang J, Y., , Guo F., , and Dong M. 2010. Prevalence of multidrug and extensively drug-resistant tuberculosis in Beijing, China: a hospital-based retrospective study. Jpn. J. Infect. Dis., 63:368\u2013371.","journal-title":"Jpn. J. Infect. Dis."},{"key":"e_1_3_3_10_2","unstructured":"World Health Organization. 1998. Laboratory Services in Tuberculosis Control. Part III: Culture. Available at http:\/\/whqlibdoc.who.int\/hq\/1998\/WHO_TB_98.258_(part3).pdf (accessed December18 2014). (Online.)"},{"key":"e_1_3_3_11_2","unstructured":"World Health Organization. 2010. The Stop TB Strategy. 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