{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:52:41Z","timestamp":1789944761198,"version":"4.0.1"},"reference-count":29,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Acinetobacter baumannii<\/jats:italic>\n                    , a substantial nosocomial pathogen, has developed resistance to almost all available antimicrobial drugs. Bacteriophage therapy is a possible alternative treatment for multidrug-resistant (MDR) bacterial infections. In this study, we have successfully isolated bacteriophage active against clinical strains of\n                    <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                    by enrichment from hospital sewage sludge using representatives of those strains. The bacteriophage isolated against\n                    <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                    formed plaques against beta-lactamases producing strains of\n                    <jats:italic toggle=\"yes\">A. baumannii.<\/jats:italic>\n                    The utility of bacteriophage specific for\n                    <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                    to resolve wound infection in uncontrolled diabetic rats was evaluated. Five groups of uncontrolled diabetic rats were used. Group I was noninfected (Control), Group II was infected with MDR\n                    <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                    and challenged with bacteriophage, Group III was infected with MDR\n                    <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                    , Group IV was infected with MDR\n                    <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                    and challenged with antibiotic colistin, and Group V consisted of noninfected rats and sprayed with phage (Phage control). A significant decrease in infection, period of epithelization, and wound contraction was observed in the phage-challenged group when compared with antibiotic-treated uncontrolled diabetic rats and the control group. To conclude the study, new insights are provided into the biology of the broad host range of\n                    <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                    phage, demonstrating that\n                    <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                    phage has prospects for the treatment of infections caused by the MDR\n                    <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1089\/mdr.2014.0120","type":"journal-article","created":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T12:40:59Z","timestamp":1416487259000},"page":"171-177","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":47,"title":["Ability of Bacteriophage in Resolving Wound Infection Caused by Multidrug-Resistant\n                    <i>Acinetobacter baumannii<\/i>\n                    in Uncontrolled Diabetic Rats"],"prefix":"10.1177","volume":"21","author":[{"given":"VinodKumar Chickmangalure","family":"Shivaswamy","sequence":"first","affiliation":[{"name":"S.S. Institute of Medical Sciences and Research Centre","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suneeta Basavaraj","family":"Kalasuramath","sequence":"additional","affiliation":[{"name":"S.S. Institute of Medical Sciences and Research Centre","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chethan Kumar","family":"Sadanand","sequence":"additional","affiliation":[{"name":"S.S. Institute of Medical Sciences and Research Centre","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek Kilagere","family":"Basavaraju","sequence":"additional","affiliation":[{"name":"S.S. Institute of Medical Sciences and Research Centre","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha","family":"Ginnavaram","sequence":"additional","affiliation":[{"name":"S.S. Institute of Medical Sciences and Research Centre","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumanth","family":"Bille","sequence":"additional","affiliation":[{"name":"S.S. Institute of Medical Sciences and Research Centre","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay Saju","family":"Ukken","sequence":"additional","affiliation":[{"name":"S.S. Institute of Medical Sciences and Research Centre","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha Nandini","family":"Pushparaj","sequence":"additional","affiliation":[{"name":"S.S. Institute of Medical Sciences and Research Centre","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,4]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-007-0371-8"},{"key":"e_1_3_2_3_2","first-page":"160","article-title":"Detection of extended spectrum \u03b2-lactamase producers among surgical wound infections and burn patients in JIPMER","volume":"18","author":"Ananthakrishnan A.N.","year":"2004","unstructured":"Ananthakrishnan A.N., , Kanungo R., , Kumar A., , and Badrinath S.. 2004. Detection of extended spectrum \u03b2-lactamase producers among surgical wound infections and burn patients in JIPMER. Ind. J. Med. Microbiol., 18:160\u2013165.","journal-title":"Ind. J. Med. Microbiol."},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"e22674","DOI":"10.1371\/journal.pone.0022674","article-title":"Deciphering the multifactorial nature of Acinetobacter baumannii pathogenicity","volume":"6","author":"Antunes L.C.","year":"2011","unstructured":"Antunes L.C., , Imperi F., , Carattoli A., , and Visca P.. 2011. Deciphering the multifactorial nature of Acinetobacter baumannii pathogenicity. PLoS One, 6:e22674.","journal-title":"PLoS One"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/ajcp\/45.4_ts.493","article-title":"Antibiotic susceptibility testing methods","volume":"45","author":"Bauer A.W.","year":"1966","unstructured":"Bauer A.W., , Kirby W.M., , Sherri J.C., , and Turkek M.. 1966. Antibiotic susceptibility testing methods. Am. J. Clin. Pathol., 45:493\u2013498.","journal-title":"Am. J. Clin. Pathol."},{"key":"e_1_3_2_6_2","first-page":"5","article-title":"The efficacy of Klebsiella bacteriophage in the therapy of experimental Klebsiella infection","volume":"4","author":"Bojovazova G.G.","year":"1991","unstructured":"Bojovazova G.G., , Voroshilova N.N., , and Bondarenko V.M.. 1991. The efficacy of Klebsiella bacteriophage in the therapy of experimental Klebsiella infection. J. Microbiol. Epidemiol. Immunobiol., 4:5\u20138.","journal-title":"J. Microbiol. Epidemiol. Immunobiol."},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1128\/AAC.45.3.710-714.2001","article-title":"IMP-4, a novel metallo-\u03b2-lactamase from nosocomial Acinetobacter spp. collected in Hong Kong between 1994 and 1998","volume":"45","author":"Chu Y.-W.","year":"2001","unstructured":"Chu Y.-W., , Afzal-Shah M., , Houang E.T.S., , Palepou M.-F.I., , Lyon D.J., , Woodford N., , and Livermore D.M.. 2001. IMP-4, a novel metallo-\u03b2-lactamase from nosocomial Acinetobacter spp. collected in Hong Kong between 1994 and 1998. Antimicrob. Agents Chemother., 45:710\u2013714.","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_3_2_8_2","first-page":"42662","article-title":"Quantitative Gram stain interpretation criteria used by microbiology laboratory in Alberta, Canada","volume":"12","author":"Deirdre C.","year":"2000","unstructured":"Deirdre C., , Elizabeth M., , and Barbara U.. 2000. Quantitative Gram stain interpretation criteria used by microbiology laboratory in Alberta, Canada. J. Clin. Microbiol., 12:42662\u201342668.","journal-title":"J. Clin. Microbiol."},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/nrmicro1789","article-title":"An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii","volume":"12","author":"Dijkshoorn L.","year":"2007","unstructured":"Dijkshoorn L., , Nemec A., , and Seifert H.. 2007. An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii. Nat. Rev. Microbiol., 12:939\u2013951.","journal-title":"Nat. Rev. Microbiol."},{"key":"e_1_3_2_10_2","first-page":"128","article-title":"Michelia champaca: wound healing activity in immunosuppressed rats","volume":"7","author":"Dwajani S.","year":"2009","unstructured":"Dwajani S., , and Shanbhag T.. 2009. Michelia champaca: wound healing activity in immunosuppressed rats. Internet J. Altern. Med., 7:128\u2013132.","journal-title":"Internet J. Altern. Med."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-9-9"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/1471-2180-12-156","article-title":"Isolation and characterization of ZZ1, a novel lytic phage that infects Acinetobacter baumannii clinical isolates","volume":"12","author":"Jin J.","year":"2012","unstructured":"Jin J., , Li Z.J., , Wang S.W., , Wang S.M., , Huang D.H., , Li Y.H., , Ma Y.Y., , Wang J., , Liu F., , Chen X.D., , Li G.X., , Wang X.T., , Wang Z.Q., , and Zhao G.Q.. 2012. Isolation and characterization of ZZ1, a novel lytic phage that infects Acinetobacter baumannii clinical isolates. BMC Microbiol., 12:156\u2013164.","journal-title":"BMC Microbiol."},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/wrr.12056","article-title":"Wound healing potential of topical bacteriophage therapy on diabetic cutaneous wounds","volume":"21","author":"Joao J.M.","year":"2013","unstructured":"Joao J.M., , Leandro C., , Corte-Real S., , Barbosa R., , Cavaco Silva P., , Melo Cristino J., , Gorski A., , and Garcia M.. 2013. Wound healing potential of topical bacteriophage therapy on diabetic cutaneous wounds. Wound Repair Regen. 21:595\u2013603.","journal-title":"Wound Repair Regen"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0255-0857(21)02352-5","article-title":"Occurrence of extended spectrum \u03b2-lactamases among Enterobacteriaceae species isolated at a tertiary care institute","volume":"24","author":"Kumar M.S.","year":"2006","unstructured":"Kumar M.S., , Lakshmi V., , and Rajagopalan R.. 2006. Occurrence of extended spectrum \u03b2-lactamases among Enterobacteriaceae species isolated at a tertiary care institute. Indian J. Med. Microbial., 24:208\u2013211.","journal-title":"Indian J. Med. Microbial."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0886-7"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2010.03.007"},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/1471-2180-8-139","article-title":"Inducible Siphoviruses in superficial and deep tissue isolates of Propionibacterium acnes","volume":"8","author":"Lood R.","year":"2008","unstructured":"Lood R., , Morgelin M., , Holmberg A., , Rasmussen M., , and Collin M.. 2008. Inducible Siphoviruses in superficial and deep tissue isolates of Propionibacterium acnes. BMC Microbiol., 8:139.","journal-title":"BMC Microbiol."},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1574-6976.2012.00344.x","article-title":"Acinetobacter baumannii: human infections, factors contributing to pathogenesis and animal models","volume":"37","author":"McConnell M.J.","year":"2012","unstructured":"McConnell M.J., et al. 2012. Acinetobacter baumannii: human infections, factors contributing to pathogenesis and animal models. FEMS Microbiol. Rev., 37:130\u2013155.","journal-title":"FEMS Microbiol. Rev."},{"key":"e_1_3_2_19_2","first-page":"290","article-title":"The influence of tricyclic antidepressants on resutured incision & deep space wound healing","volume":"31","author":"Muppayavarmath S.S.","year":"1999","unstructured":"Muppayavarmath S.S., , and Patil P.A.. 1999. The influence of tricyclic antidepressants on resutured incision & deep space wound healing. Indian J. Pharmacol., 31:290\u2013293.","journal-title":"Indian J. Pharmacol."},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/bmme.1997.2622","article-title":"Changes in plasma glucose, insulin, glucagon, cathecolmine, and glicogen contentes in tissue during development of alloxan diabetes in rats","volume":"62","author":"Oi K.","year":"1997","unstructured":"Oi K., , Komori H., , and Kajimura H.. 1997. Changes in plasma glucose, insulin, glucagon, cathecolmine, and glicogen contentes in tissue during development of alloxan diabetes in rats. Biochem. Mol. Med., 62:70\u201375.","journal-title":"Biochem. Mol. Med."},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1574-6968.2012.02573.x","article-title":"Isolation and characterization of wide host range lytic bacteriophage AP22 infecting Acinetobacter baumannii","volume":"332","author":"Popova A.V.","year":"2012","unstructured":"Popova A.V., et al. 2012. Isolation and characterization of wide host range lytic bacteriophage AP22 infecting Acinetobacter baumannii. FEMS Microbiol. Lett., 332:40\u201346.","journal-title":"FEMS Microbiol. Lett."},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.5897\/AJMR2013.6548","article-title":"Prevalence of metallo beta-lactamases producers among carbapenem resistant Acinetobacter baumannii strains isolated from diabetic foot ulcers","volume":"8","author":"Rasha A.","year":"2014","unstructured":"Rasha A., , Alm El-Din, , Ei-Bassat H., , E1-Bedewy M., , and El-Mohamady H.. 2014. Prevalence of metallo beta-lactamases producers among carbapenem resistant Acinetobacter baumannii strains isolated from diabetic foot ulcers. Afr. J. Microbiol. Res., 8:1580\u20131585.","journal-title":"Afr. J. Microbiol. Res."},{"key":"e_1_3_2_23_2","first-page":"267","article-title":"Results of bacteriophage treatment of suppurative bacterial infections. I. General evaluation of the results","volume":"31","author":"Slopek S.","year":"1983","unstructured":"Slopek S., , Durlakowa I., , Weber-Dabrowska B., , Kucharewicz-Krukowska A., , Dabrowski M., , and Bisikiewicz R.. 1983. Results of bacteriophage treatment of suppurative bacterial infections. I. General evaluation of the results. Arch. Immunol. Ther. Exp., 31:267\u2013291.","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"e_1_3_2_24_2","first-page":"307","article-title":"Successful treatment of experimental E. coli infections in mice using phage; its superiority over antibiotics","volume":"128","author":"Smith H.W.","year":"1982","unstructured":"Smith H.W., , and Huggins M.B.. 1982. Successful treatment of experimental E. coli infections in mice using phage; its superiority over antibiotics. J. Gen. Microbiol., 128:307\u2013318.","journal-title":"J. Gen. Microbiol."},{"key":"e_1_3_2_25_2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1089\/mdr.2006.12.164","article-title":"Augmentation of antimicrobial efficacy of antibiotics by filamentous phage","volume":"12","author":"Steven H.","year":"2006","unstructured":"Steven H., , Habel A., , and Blash U.. 2006. Augmentation of antimicrobial efficacy of antibiotics by filamentous phage. Microb. Drug Resist., 12:164\u2013168.","journal-title":"Microb. Drug Resist."},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1086\/595977"},{"key":"e_1_3_2_27_2","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1517\/14656566.9.4.587","article-title":"Therapeutic options for Acinetobacter baumannii infections","volume":"9","author":"Vila J.","year":"2008","unstructured":"Vila J., , and Pach\u00f3n J.. 2008. Therapeutic options for Acinetobacter baumannii infections. Expert Opin. Pharmacother., 9:587\u2013599.","journal-title":"Expert Opin. Pharmacother."},{"key":"e_1_3_2_28_2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.25004\/IJPSDR.2011.030307","article-title":"Abrogation of Staphylococcus aureus wound infection by bacteriophage in diabetic rats","volume":"3","author":"VinodKumar C.S.","year":"2011","unstructured":"VinodKumar C.S., , Srinivasa H., , Basavarajappa K.G., , Umakanth P., , Nitin B., , and Rajashri P.. 2011. Abrogation of Staphylococcus aureus wound infection by bacteriophage in diabetic rats. Int. J. Pharm. Drug Res., 3:202\u2013207.","journal-title":"Int. J. Pharm. Drug Res."},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","first-page":"360","DOI":"10.4103\/0377-4929.42511","article-title":"Utility of lytic bacteriophage in the treatment of multidrug resistant Pseudomonas aeruginosa septicemia in mice","volume":"51","author":"VinodKumar C.S.","year":"2008","unstructured":"VinodKumar C.S., , Suneeta K., , and Neelagund Y.F.. 2008. Utility of lytic bacteriophage in the treatment of multidrug resistant Pseudomonas aeruginosa septicemia in mice. Ind. J. Pathol. Microbiol., 51:360\u2013366.","journal-title":"Ind. J. Pathol. Microbiol."},{"key":"e_1_3_2_30_2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/1471-2180-10-131","article-title":"Isolation and characterization of a virulent bacteriophage AB1 of Acinetobacter baumannii","volume":"10","author":"Yang H.","year":"2012","unstructured":"Yang H., et al. 2012. Isolation and characterization of a virulent bacteriophage AB1 of Acinetobacter baumannii. BMC Microbiol., 10:131.","journal-title":"BMC Microbiol."}],"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/mdr.2014.0120","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2014.0120","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2014.0120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:28:48Z","timestamp":1777667328000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/mdr.2014.0120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1089\/mdr.2014.0120"],"URL":"https:\/\/doi.org\/10.1089\/mdr.2014.0120","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4]]}}}