{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:13:51Z","timestamp":1790396031255,"version":"4.1.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2015,6]]},"abstract":"\n The aim of this study was to investigate the infections due to OXA-48 carbapenemase-producing bacteria in tertiary hospitals in Kuwait (September 2011 to April 2013) and to determine the sequence types (STs) of the corresponding isolates. Eleven OXA-48 carbapenemase-producing\n Enterobacteriaceae<\/jats:italic>\n isolates were recovered from patients treated in nine different hospitals in Kuwait. Susceptibility testing to eighteen antibiotics was done using the E-test. PCR assays were performed for the detection of genes encoding extended-spectrum \u03b2-lactamases (ESBLs) (\n bla<\/jats:italic>\n CTX-M<\/jats:sub>\n ,\n bla<\/jats:italic>\n SHV<\/jats:sub>\n , and\n bla<\/jats:italic>\n TEM<\/jats:sub>\n ) and carbapenemases (\n bla<\/jats:italic>\n OXA-48<\/jats:sub>\n ,\n bla<\/jats:italic>\n VIM<\/jats:sub>\n ,\n bla<\/jats:italic>\n NDM<\/jats:sub>\n ,\n bla<\/jats:italic>\n IMP<\/jats:sub>\n ,\n bla<\/jats:italic>\n GIM<\/jats:sub>\n , and\n bla<\/jats:italic>\n KPC<\/jats:sub>\n ). STs were determined by Multilocus Sequence Typing. Seven\n Klebsiella pneumoniae<\/jats:italic>\n , two\n Escherichia coli<\/jats:italic>\n , one\n Enterobacter cloacae<\/jats:italic>\n , and one\n Morganella morganii<\/jats:italic>\n harbored the\n bla<\/jats:italic>\n OXA-48<\/jats:sub>\n gene. The\n K<\/jats:italic>\n .\n pneumoniae<\/jats:italic>\n and\n E. coli<\/jats:italic>\n belonged to seven and two different STs, respectively, which were not related to those reported from this region. The majority of the isolates carried either\n bla<\/jats:italic>\n CTX-M<\/jats:sub>\n or\n bla<\/jats:italic>\n SHV<\/jats:sub>\n genes and showed a multidrug-resistant phenotype, including resistance to tigecycline. Multidrug-resistant\n Enterobacteriaceae<\/jats:italic>\n harboring the\n bla<\/jats:italic>\n OXA-48<\/jats:sub>\n gene are emerging in Kuwait with different STs compared to those identified in other countries of the region. Detection of OXA-48-producing\n Enterobacteriaceae<\/jats:italic>\n in Kuwait is important to prevent its rapid spread.\n <\/jats:p>","DOI":"10.1089\/mdr.2014.0123","type":"journal-article","created":{"date-parts":[[2014,12,31]],"date-time":"2014-12-31T10:00:52Z","timestamp":1420020052000},"page":"329-334","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["Emergence of New Sequence Type OXA-48 Carbapenemase-Producing\n Enterobacteriaceae<\/i>\n in Kuwait"],"prefix":"10.1177","volume":"21","author":[{"given":"Wafaa Y.","family":"Jamal","sequence":"first","affiliation":[{"name":"Kuwait University","place":["Kuwait"]},{"name":"Mubarak Al-Kabir Hospital","place":["Kuwait"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. John","family":"Albert","sequence":"additional","affiliation":[{"name":"Kuwait University","place":["Kuwait"]},{"name":"Mubarak Al-Kabir Hospital","place":["Kuwait"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Khodakhast","sequence":"additional","affiliation":[{"name":"Kuwait University","place":["Kuwait"]},{"name":"Mubarak Al-Kabir Hospital","place":["Kuwait"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Poirel","sequence":"additional","affiliation":[{"name":"University of Fribourg","place":["Switzerland"]},{"name":"INSERM U914, South-Paris Medical School, K.-Bic\u00eatre, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent O.","family":"Rotimi","sequence":"additional","affiliation":[{"name":"Kuwait University","place":["Kuwait"]},{"name":"Mubarak Al-Kabir Hospital","place":["Kuwait"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1093\/jac\/dkr382","article-title":"Introduction of OXA-48-producing Enterobacteriaceae to Israeli hospitals by medical tourism","volume":"66","author":"Adler A.","year":"2011","unstructured":"Adler A., , Shklyar M., , Schwaber M.J., , Navan-Venezia S., , Dhaher Y., , Edgar R., , Solter E., , Benenson S., , Masarwa S., , and Garmeli Y. 2011. 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