{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:32:53Z","timestamp":1783953173518,"version":"3.55.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T00:00:00Z","timestamp":1426550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2015,8,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Stenotrophomonas maltophilia<\/jats:italic>\n                    is an emerging nosocomial pathogen responsible for serious human infections. This study was carried out to determine antibiotic susceptibility, resistance mechanisms (integrons,\n                    <jats:italic toggle=\"yes\">sul1<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">sul2<\/jats:italic>\n                    ), and genetic relatedness (Enterobacterial Repetitive Intergenic Consensus [ERIC]-PCR) among 106 clinical isolates of\n                    <jats:italic toggle=\"yes\">S. maltophilia<\/jats:italic>\n                    from India. Twenty-four (22.6%) of\n                    <jats:italic toggle=\"yes\">S. maltophilia<\/jats:italic>\n                    isolates exhibited resistance to mainstay antibiotic trimethoprim\u2013sulfamethoxazole (TMP-SMX). Except for 2 isolates which contained both TMP-SMX resistance determinants\n                    <jats:italic toggle=\"yes\">sul1<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">sul2<\/jats:italic>\n                    genes, all other 22 TMP-SMX-resistant isolates carried either\n                    <jats:italic toggle=\"yes\">sul1<\/jats:italic>\n                    (10 isolates) or\n                    <jats:italic toggle=\"yes\">sul2<\/jats:italic>\n                    (12 isolates) genes. Class 1 integrons were present in 8.5% (9 out of 106) of\n                    <jats:italic toggle=\"yes\">S. maltophilia<\/jats:italic>\n                    isolates, and only 5 out of these isolates were TMP-SMX resistant and positive for\n                    <jats:italic toggle=\"yes\">sul1<\/jats:italic>\n                    gene. The same isolates also carried resistance cassettes containing\n                    <jats:italic toggle=\"yes\">qac\/smr<\/jats:italic>\n                    gene. Minocycline and levofloxacin exhibited the maximum\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    activity against\n                    <jats:italic toggle=\"yes\">S. maltophilia<\/jats:italic>\n                    . ERIC-PCR revealed high diversity among\n                    <jats:italic toggle=\"yes\">S. maltophilia<\/jats:italic>\n                    isolates. The present study demonstrated high (22.4%) TMP-SMX resistance in clinical isolates of\n                    <jats:italic toggle=\"yes\">S. maltophilia<\/jats:italic>\n                    from India. TMP-SMX-resistant isolates carried relatively higher percentage of\n                    <jats:italic toggle=\"yes\">sul2<\/jats:italic>\n                    gene than\n                    <jats:italic toggle=\"yes\">sul1<\/jats:italic>\n                    gene as against the reported literature. Majority (58.3%) of\n                    <jats:italic toggle=\"yes\">sul1<\/jats:italic>\n                    gene positive were not associated with class 1 integrase gene.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2014.0176","type":"journal-article","created":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T09:59:24Z","timestamp":1426586364000},"page":"380-385","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":36,"title":["Distribution of Class 1 Integrons,\n                    <i>sul1<\/i>\n                    and\n                    <i>sul2<\/i>\n                    Genes Among Clinical Isolates of\n                    <i>Stenotrophomonas maltophilia<\/i>\n                    from a Tertiary Care Hospital in North India"],"prefix":"10.1177","volume":"21","author":[{"given":"Parvinder","family":"Kaur","sequence":"first","affiliation":[{"name":"Panjab University","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Gautam","sequence":"additional","affiliation":[{"name":"Postgraduate Institute of Medical Education and Research","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupinder","family":"Tewari","sequence":"additional","affiliation":[{"name":"Panjab University","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,3,17]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/0255-0857.103785"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.2.666-669.2004"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2008.07.001"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/45.4_ts.493"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00019-11"},{"key":"e_1_3_3_7_2","first-page":"113","article-title":"Plasmid mediated antimicrobial resistance in Salmonella enteric","volume":"5","author":"Carattoli A.","year":"2003","unstructured":"Carattoli A. 2003. Plasmid mediated antimicrobial resistance in Salmonella enteric. Curr. Issues Mol. Biol., 5:113\u2013122.","journal-title":"Curr. Issues Mol. Biol."},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.7883\/yoken.JJID.2004.37"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm034"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.33.4.912-914.1995"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-777X.121996"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01682-13"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2013.28.1.62"},{"key":"e_1_3_3_14_2","unstructured":"[CLSI] Clinical and Laboratory Standards Institute. 2012. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically: Approved Standards. Ninth Edition. Clinical and Laboratory Standards Institute Wayne PA M07-A9."},{"key":"e_1_3_3_15_2","unstructured":"[CLSI] Clinical and Laboratory Standards Institute. 2014. Performance Standards for Antimicrobial Susceptibility Testing. Twenty fourth Information Supplement. Clinical and Laboratory Standards Institute Wayne PA M100-S24."},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.009431-0"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01774-09"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.4103\/0255-0857.49425"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.5.1802-1807.2005"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2005.01257.x"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.034140-0"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-7646(98)80026-5"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2010.10.025"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf164"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.1.8-13.2001"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.1.185"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.94056"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2727.59701"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.6.1568-1574.2000"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.8.3989-3990.2003"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2012.00938.x"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2012.04.004"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-007-0279-3"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2014.01.007"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.4103\/0377-4929.85150"},{"key":"e_1_3_3_36_2","first-page":"295","article-title":"Analysis of acquired resistance genes in Stenotrophomonas maltophilia","volume":"30","author":"Song J. H.","year":"2010","unstructured":"Song J. H., , Sung J.Y., , Kwon K.C., , Park J.W., , Cho H.H., , Shin S.Y., , Ko Y.H., , Kim J.M., , Shin K.S., , and Koo S.H. 2010. Analysis of acquired resistance genes in Stenotrophomonas maltophilia. Korean J. Lab. Med., 30:295\u2013300.","journal-title":"Korean J. Lab. Med."},{"key":"e_1_3_3_37_2","first-page":"1696","article-title":"Meningitis due to Stenotrophomonas maltophilia after a neurosurgical procedure","volume":"7","author":"Sood S.","year":"2013","unstructured":"Sood S., , Vaid V.K., , and Bhartiya H. 2013. Meningitis due to Stenotrophomonas maltophilia after a neurosurgical procedure. J. Clin. Diagn. Res., 7:1696\u20131697.","journal-title":"J. Clin. Diagn. Res."},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2007.09.007"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756-185X.2009.01447.x"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1304.061378"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.2.693-699.2003"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/19.24.6823"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-011-0063-4"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.12.4305-4309.2000"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2011.09.028"}],"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/mdr.2014.0176","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2014.0176","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2014.0176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:28:55Z","timestamp":1777667335000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/mdr.2014.0176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,17]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,8,1]]}},"alternative-id":["10.1089\/mdr.2014.0176"],"URL":"https:\/\/doi.org\/10.1089\/mdr.2014.0176","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,17]]}}}