{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T17:05:59Z","timestamp":1779383159131,"version":"3.53.1"},"reference-count":37,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T00:00:00Z","timestamp":1425945600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2015,8,1]]},"abstract":"\n This study aimed to determine the prevalence of extended-spectrum beta-lactamases (ESBLs) in\n Enterobacteriaceae<\/jats:italic>\n and to characterize the genetic composition of ESBL determinants among\n Enterobacteriaceae<\/jats:italic>\n isolates from healthy people in Guangzhou, China. A total of 200 rectal swab samples were collected from healthy asymptomatic individuals and tested for ESBL production using ChromID ESBL agar. Phenotypic ESBL producers were screened for\n bla<\/jats:italic>\n CTX-M<\/jats:sub>\n ,\n bla<\/jats:italic>\n TEM<\/jats:sub>\n , and\n bla<\/jats:italic>\n SHV<\/jats:sub>\n genes using PCR and DNA sequencing. The prevalence of ESBL-producing\n Enterobacteriaceae<\/jats:italic>\n among rectal swab samples was 69.5%. All ESBL-producing isolates harbored\n bla<\/jats:italic>\n CTX-M<\/jats:sub>\n genes (\n n<\/jats:italic>\n =138) except for one isolate that harbored\n bla<\/jats:italic>\n SHV-2a<\/jats:sub>\n . Eleven CTX-M ESBL genes were detected. The most predominant CTX-M-type genes were\n bla<\/jats:italic>\n CTX-M-14<\/jats:sub>\n (\n n<\/jats:italic>\n =82), followed by\n bla<\/jats:italic>\n CTX-M-55<\/jats:sub>\n (\n n<\/jats:italic>\n =19),\n bla<\/jats:italic>\n CTX-M-65<\/jats:sub>\n (\n n<\/jats:italic>\n =10), and\n bla<\/jats:italic>\n CTX-M-27<\/jats:sub>\n (\n n<\/jats:italic>\n =9). Isolates carrying\n bla<\/jats:italic>\n CTX-M-38<\/jats:sub>\n ,\n -3<\/jats:sub>\n ,\n -15<\/jats:sub>\n ,\n -14b<\/jats:sub>\n ,\n -98<\/jats:sub>\n ,\n -121<\/jats:sub>\n and\n -123<\/jats:sub>\n were also identified. Molecular homology analysis of the selected isolates was performed by phylogenetic grouping and multilocus sequence typing and indicated that the predominant clone belonged to A-CC10. This study showed a high rate of CTX-M-type ESBL genes among\n Enterobacteriaceae<\/jats:italic>\n isolates from healthy individuals in China.\n <\/jats:p>","DOI":"10.1089\/mdr.2014.0201","type":"journal-article","created":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T09:53:29Z","timestamp":1425981209000},"page":"398-403","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["High Prevalence of CTX-M Beta-Lactamases in\n Enterobacteriaceae<\/i>\n from Healthy Individuals in Guangzhou, China"],"prefix":"10.1177","volume":"21","author":[{"given":"Yong","family":"Zhou","sequence":"first","affiliation":[{"name":"Microbiology Test Laboratory","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinwei","family":"Wu","sequence":"additional","affiliation":[{"name":"Microbiology Test Laboratory","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Microbiology Test Laboratory","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Tao","sequence":"additional","affiliation":[{"name":"Microbiology Test Laboratory","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiai","family":"Deng","sequence":"additional","affiliation":[{"name":"Microbiology Test Laboratory","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushan","family":"Hu","sequence":"additional","affiliation":[{"name":"Microbiology Test Laboratory","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixia","family":"Li","sequence":"additional","affiliation":[{"name":"Microbiology Test Laboratory","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Yang","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Wang","sequence":"additional","affiliation":[{"name":"Microbiology Test Laboratory","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicong","family":"Yang","sequence":"additional","affiliation":[{"name":"Microbiology Test Laboratory","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,3,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.4.933-951.2001"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq238"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2006.08.011"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp194"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-003-1084-2"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/1746-6148-8-140"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01468-12"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2009.02.021"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05539-11"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02221-06"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096738"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00541-13"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01740-13"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/519865"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-012-0272-3"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03497.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2010.538856"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.12.015"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-12-53"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks118"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl211"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-012-0324-8"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1707.110209"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2009.11.003"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(08)70041-0"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks126"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-011-1202-5"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03127.x"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1139\/W08-059"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.10.4769-4775.2004"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01008-08"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00023-13"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100707"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2006.01.014"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.012229-0"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.3109\/1040841X.2012.691460"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2011.12.001"}],"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/mdr.2014.0201","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2014.0201","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2014.0201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:28:58Z","timestamp":1777667338000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/mdr.2014.0201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,10]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,8,1]]}},"alternative-id":["10.1089\/mdr.2014.0201"],"URL":"https:\/\/doi.org\/10.1089\/mdr.2014.0201","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,10]]}}}