{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:07:35Z","timestamp":1792001255948,"version":"4.4.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>\n                    Enterococci are gram-positive cocci responsible for various infections worldwide, and their prevalence of antibiotic resistance greatly varies worldwide. This study investigates the prevalence of resistance to antibiotics in enterococci from patients admitted in the four university hospitals of Marseille between January 2013 and September 2014. Two thousand nine hundred seventy-six patients-bacteria couples were identified (2,507\n                    <jats:italic toggle=\"yes\">Enterococcus faecalis<\/jats:italic>\n                    and 469\n                    <jats:italic toggle=\"yes\">Enterococcus faecium<\/jats:italic>\n                    ) in the four university hospitals of Marseille. 1.3%, 8.9%, 1.4%, and 0% of\n                    <jats:italic toggle=\"yes\">E. faecalis<\/jats:italic>\n                    strains were resistant to amoxicillin, gentamicin, teicoplanin, and vancomycin, respectively, and 83.9%, 49.2%, 1.3%, and 0.2% of\n                    <jats:italic toggle=\"yes\">E. faecium<\/jats:italic>\n                    strains were resistant to amoxicillin, gentamicin, teicoplanin, and vancomycin, respectively. Resistance to aminoglycosides and vancomycin in strains isolated from blood cultures was significantly lower than that of most European countries included in the 2012 European Antimicrobial Resistance Surveillance Network report. Our low percentage of antibiotic resistance in enterococci is likely due to a low level of\n                    <jats:italic toggle=\"yes\">E. faecium<\/jats:italic>\n                    infections, underlining the need to implement surveillance systems, especially to monitor the\n                    <jats:italic toggle=\"yes\">E. faecalis<\/jats:italic>\n                    \/\n                    <jats:italic toggle=\"yes\">E. faecium<\/jats:italic>\n                    ratio evolution in blood cultures and others.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2015.0121","type":"journal-article","created":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T15:22:59Z","timestamp":1438874579000},"page":"218-222","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Low Level of Resistance in Enterococci Isolated in Four Hospitals, Marseille, France"],"prefix":"10.1177","volume":"22","author":[{"given":"C\u00e9dric","family":"Abat","sequence":"first","affiliation":[{"name":"Aix-Marseille Universit\u00e9","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Raoult","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universit\u00e9","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Rolain","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universit\u00e9","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,4]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2010.0171"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2761"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(01)00145-1"},{"key":"e_1_3_3_5_2","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/jac\/dks469","article-title":"Twenty-five years of shared life with vancomycin-resistant enterococci: is it time to divorce?","volume":"68","author":"Cattoir V.","year":"2012","unstructured":"Cattoir V., , and Leclercq R. 2012. Twenty-five years of shared life with vancomycin-resistant enterococci: is it time to divorce?. J. Antimicrob. Chemother., 68:731\u2013742.","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_3_6_2","doi-asserted-by":"crossref","first-page":"E199","DOI":"10.33321\/cdi.2013.37.31","article-title":"Australian Group on Antimicrobial Resistance Enterococcus Surveillance Programme annual report, 2010","volume":"37","author":"Coombs G.W.","year":"2013","unstructured":"Coombs G.W., , Pearson J.C., , Christiansen K., , Gottlieb T., , Bell J.M., , George N., et al. 2013. Australian Group on Antimicrobial Resistance Enterococcus Surveillance Programme annual report, 2010. Commun. Dis. Intell. Q. Rep., 37:E199\u2013E209.","journal-title":"Commun. Dis. Intell. Q. Rep."},{"key":"e_1_3_3_7_2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/2047-2994-2-18","article-title":"Eradication of an outbreak of vancomycin-resistant Enterococcus (VRE): the cost of a failure in the systematic screening","volume":"2","author":"Escaut L.","year":"2013","unstructured":"Escaut L., , Bouam S., , Frank-Soltysiak M., , Rudant E., , Saliba F., , Kassis N., et al. 2013. Eradication of an outbreak of vancomycin-resistant Enterococcus (VRE): the cost of a failure in the systematic screening. Antimicrob. Resist. Infect. Control, 2:18.","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"e_1_3_3_8_2","unstructured":"European Centre for Disease Prevention and Control. 2013. Antimicrobial Resistance Surveillance in Europe 2012. Available at http:\/\/ecdc.europa.eu\/en\/publications\/Publications\/antimicrobial-resistance-surveillance europe-2012.pdf. (Online.)"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-012-1667-x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"crossref","first-page":"e30187","DOI":"10.1371\/journal.pone.0030187","article-title":"Genomic and SNP analyses demonstrate a distant separation of the hospital and community-associated clades of Enterococcus faecium","volume":"7","author":"Galloway-Pe\u00f1a J.","year":"2012","unstructured":"Galloway-Pe\u00f1a J., , Roh J.H., , Latorre M., , Qin X., , and Murray B.E. 2012. Genomic and SNP analyses demonstrate a distant separation of the hospital and community-associated clades of Enterococcus faecium. PLoS One, 7:e30187.","journal-title":"PLoS One"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2010.0552"},{"issue":"4","key":"e_1_3_3_12_2","first-page":"S265","article-title":"[Interventions implemented to control an outbreak of vancomycin-resistant enterococci in a university hospital]","volume":"5","author":"Henard S.","year":"2009","unstructured":"Henard S., , Cao-Huu T., , Loos-Ayav C., , Chanet P., , Kessler M., , and Rabaud C. 2009. [Interventions implemented to control an outbreak of vancomycin-resistant enterococci in a university hospital]. Nephrol. Ther., 5 Suppl 4:S265\u2013S271.","journal-title":"Nephrol. Ther."},{"key":"e_1_3_3_13_2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jhin.2007.06.009","article-title":"Rapid control of an outbreak of vancomycin-resistant enterococci in a French university hospital","volume":"67","author":"Lucet J.-C.","year":"2007","unstructured":"Lucet J.-C., , Armand-Lefevre L., , Laurichesse J.-J., , Macrez A., , Papy E., , Ruimy R., et al. 2007. Rapid control of an outbreak of vancomycin-resistant enterococci in a French university hospital. J. Hosp. Infect., 67:42\u201348.","journal-title":"J. Hosp. Infect."},{"key":"e_1_3_3_14_2","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1093\/jac\/dkt376","article-title":"Outbreak in a haematology unit involving an unusual strain of glycopeptide-resistant Enterococcus faecium carrying both vanA and vanB genes","volume":"69","author":"Marcad\u00e9 G.","year":"2014","unstructured":"Marcad\u00e9 G., , Micol J.-B., , Jacquier H., , Raskine L., , Donay J.-L., , Nicolas-Viaud S., et al. 2014. Outbreak in a haematology unit involving an unusual strain of glycopeptide-resistant Enterococcus faecium carrying both vanA and vanB genes. J. Antimicrob. Chemother., 69:500\u2013505.","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_3_15_2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3201\/eid0401.980106","article-title":"Diversity among multidrug-resistant enterococci","volume":"4","author":"Murray B.E.","year":"1998","unstructured":"Murray B.E. 1998. Diversity among multidrug-resistant enterococci. Emerg. Infect. Dis., 4:37\u201347.","journal-title":"Emerg. Infect. Dis."},{"key":"e_1_3_3_16_2","doi-asserted-by":"crossref","first-page":"e00227","DOI":"10.1128\/mBio.00227-10","article-title":"Multidrug-resistant enterococci lack CRISPR-cas","volume":"1","author":"Palmer K.L.","year":"2010","unstructured":"Palmer K.L., , and Gilmore M.S. 2010. Multidrug-resistant enterococci lack CRISPR-cas. MBio., 1: e00227\u201310; Doi: 10.1128\/mBio.00227-10.","journal-title":"MBio."},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12236"},{"key":"e_1_3_3_18_2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jhin.2009.12.007","article-title":"Trends in antimicrobial resistance of clinical isolates of Enterococcus faecalis and Enterococcus faecium in Greece between 2002 and 2007","volume":"75","author":"Protonotariou E.","year":"2010","unstructured":"Protonotariou E., , Dimitroulia E., , Pournaras S., , Pitiriga V., , Sofianou D., , and Tsakris A. 2010. Trends in antimicrobial resistance of clinical isolates of Enterococcus faecalis and Enterococcus faecium in Greece between 2002 and 2007. J. Hosp. Infect., 75:225\u2013227.","journal-title":"J. Hosp. Infect."},{"key":"e_1_3_3_19_2","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1472-765X.2010.02807.x","article-title":"MLST and a genetic study of antibiotic resistance and virulence factors in vanA-containing Enterococcus from buzzards (Buteo buteo)","volume":"50","author":"Radhouani H.","year":"2010","unstructured":"Radhouani H., , Pinto L., , Coelho C., , Sargo R., , Ara\u00fajo C., , L\u00f3pez M., et al. 2010. MLST and a genetic study of antibiotic resistance and virulence factors in vanA-containing Enterococcus from buzzards (Buteo buteo). Lett. Appl. Microbiol., 50:537\u2013541.","journal-title":"Lett. Appl. Microbiol."},{"key":"e_1_3_3_20_2","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1574-695X.2012.00997.x","article-title":"Increased high-level gentamicin resistance in invasive Enterococcus faecium is associated with aac(6\u2032)Ie-aph(2\u2033)Ia-encoding transferable megaplasmids hosted by major hospital-adapted lineages","volume":"66","author":"Rosvoll T.C.S.","year":"2012","unstructured":"Rosvoll T.C.S., , Lindstad B.L., , Lunde T.M., , Hegstad K., , Aasnaes B., , Hammerum A.M., et al. 2012. Increased high-level gentamicin resistance in invasive Enterococcus faecium is associated with aac(6\u2032)Ie-aph(2\u2033)Ia-encoding transferable megaplasmids hosted by major hospital-adapted lineages. FEMS Immunol. Med. Microbiol., 66:166\u2013176.","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"e_1_3_3_21_2","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s10096-013-1868-y","article-title":"High abundance and diversity of antimicrobial resistance determinants among early vancomycin-resistant Enterococcus faecium in Poland","volume":"32","author":"Sadowy E.","year":"2013","unstructured":"Sadowy E., , Sie\u0144ko A., , Gawryszewska I., , Bojarska A., , Malinowska K., , and Hryniewicz W. 2013. High abundance and diversity of antimicrobial resistance determinants among early vancomycin-resistant Enterococcus faecium in Poland. Eur. J. Clin. Microbiol. Infect. Dis., 32:1193\u20131203.","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1086\/600885"},{"key":"e_1_3_3_23_2","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.2215\/CJN.03310509","article-title":"Rapid curbing of a vancomycin-resistant Enterococcus faecium outbreak in a nephrology department","volume":"4","author":"Servais A.","year":"2009","unstructured":"Servais A., , Mercadal L., , Brossier F., , Venditto M., , Issad B., , Isnard-Bagnis C., et al. 2009. Rapid curbing of a vancomycin-resistant Enterococcus faecium outbreak in a nephrology department. Clin. J. Am. Soc. Nephrol., 4:1559\u20131564.","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"e_1_3_3_24_2","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1590\/S1517-83822012000300026","article-title":"Molecular characterization of vanA-containing Enterococcus from migratory birds: song thrush (Turdus philomelos)","volume":"43","author":"Silva N.","year":"2012","unstructured":"Silva N., , Igrejas G., , Felgar A., , Gon\u00e7alves A., , Pacheco R., , and Poeta P. 2012. Molecular characterization of vanA-containing Enterococcus from migratory birds: song thrush (Turdus philomelos). Braz. J. Microbiol., 43:1026\u20131029.","journal-title":"Braz. J. Microbiol."},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)91037-9"},{"key":"e_1_3_3_26_2","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1093\/infdis\/173.5.1129","article-title":"Influence of oral glycopeptides on the fecal flora of human volunteers: selection of highly glycopeptide-resistant enterococci","volume":"173","author":"Van der Auwera P.","year":"1996","unstructured":"Van der Auwera P., , Pensart N., , Korten V., , Murray B.E., , and Leclercq R. 1996. Influence of oral glycopeptides on the fecal flora of human volunteers: selection of highly glycopeptide-resistant enterococci. J. Infect. Dis., 173:1129\u20131136.","journal-title":"J. Infect. Dis."}],"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/mdr.2015.0121","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2015.0121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2015.0121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:29:30Z","timestamp":1777667370000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/mdr.2015.0121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1089\/mdr.2015.0121"],"URL":"https:\/\/doi.org\/10.1089\/mdr.2015.0121","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4]]}}}