{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T06:00:48Z","timestamp":1789365648160,"version":"build-2803163510"},"reference-count":29,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>\n                    Methicillin-resistant\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    (MRSA) carrying SCC\n                    <jats:italic toggle=\"yes\">mec<\/jats:italic>\n                    type IV has emerged in hospitals worldwide. The aim of this study was to evaluate phenotypic and molecular characteristics of antimicrobial resistance in MRSA SCC\n                    <jats:italic toggle=\"yes\">mec<\/jats:italic>\n                    IV isolates, presenting different genetic backgrounds, isolated from hospitals in Rio de Janeiro. The antimicrobial resistance of 128\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    type IV isolates from 11 hospitals was characterized by the disk diffusion test and minimum inhibitory concentration (MIC) test. Mutations in\n                    <jats:italic toggle=\"yes\">par<\/jats:italic>\n                    C gene, which encodes ciprofloxacin resistance, and genes associated with macrolide\u2013lincosamide\u2013streptogramin B (MLS\n                    <jats:sub>b<\/jats:sub>\n                    ) resistance were also investigated. MRSA isolates belonging to USA400\/ST1 (60 isolates), USA800\/ST5 (40), USA1100\/ST30 (13), and other 11 (15) lineages were mainly resistant to erythromycin (68%), ciprofloxacin (56%), and clindamycin (50%). The highest antimicrobial resistance rates were found among USA400 isolates (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05). The majority of them (90%) carried only the\n                    <jats:italic toggle=\"yes\">erm<\/jats:italic>\n                    (C) gene and mainly presented two mutation types in the\n                    <jats:italic toggle=\"yes\">par<\/jats:italic>\n                    C gene. The\n                    <jats:italic toggle=\"yes\">msr<\/jats:italic>\n                    (A) gene was most frequently found among USA800 isolates (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Among MRSA type IV isolates from Rio de Janeiro hospitals, multiresistance, including mutations in\n                    <jats:italic toggle=\"yes\">par<\/jats:italic>\n                    C gene, was associated to the USA400\/ST1, while the\n                    <jats:italic toggle=\"yes\">msr<\/jats:italic>\n                    (A) gene was associated with USA800\/ST5 isolates, highlighting that these lineages could have more potential to persist in a hospital environment.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2015.0255","type":"journal-article","created":{"date-parts":[[2016,4,5]],"date-time":"2016-04-05T16:48:45Z","timestamp":1459874925000},"page":"700-706","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Molecular Markers of Antimicrobial Resistance in Methicillin-Resistant\n                    <i>Staphylococcus aureus<\/i>\n                    SCC\n                    <i>mec<\/i>\n                    IV Presenting Different Genetic Backgrounds"],"prefix":"10.1177","volume":"22","author":[{"given":"Pricilla Dias Moura","family":"de Matos","sequence":"first","affiliation":[{"name":"Institute of Microbiology","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara Lopes Rocha","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Institute of Microbiology","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Sampaio","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"Institute of Microbiology","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis Carvalho","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Universidade Est\u00e1cio de S\u00e1","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia Lopes Pontes","family":"Iorio","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliezer Menezes","family":"Pereira","sequence":"additional","affiliation":[{"name":"Science and Technology of Rio de Janeiro","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raiane Cardoso","family":"Chamon","sequence":"additional","affiliation":[{"name":"Institute of Microbiology","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1tia Regina Netto","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Institute of Microbiology","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00081-09"},{"key":"e_1_3_3_3_2","unstructured":"International Working Group on the Staphylococcal Cassette Chromosome Elements. 2015. Available at www.sccmec.org\/Pages\/SCC_aboutIWG-SCCEN.html. Accessed March8 2015."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/675283"},{"key":"e_1_3_3_5_2","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1016\/j.ajic.2012.08.008","article-title":"Methicillin-resistant Staphylococcus aureus in Rio de Janeiro hospitals: dissemination of the USA400\/ST1 and USA800\/ST5 SCCmec type IV and USA100\/ST5 SCCmec type II lineages in a public institution and polyclonal presence in a private one","volume":"41","author":"Caboclo R.M.","year":"2013","unstructured":"Caboclo R.M., , Cavalcante F.S., , Pontes Iorio N.L., , Schuenck R.P., , Olendzki A.N., , Felix M.J., , Chamon R.C., , and dos Santos K.R. 2013. Methicillin-resistant Staphylococcus aureus in Rio de Janeiro hospitals: dissemination of the USA400\/ST1 and USA800\/ST5 SCCmec type IV and USA100\/ST5 SCCmec type II lineages in a public institution and polyclonal presence in a private one. Am. J. Infect. Control., 41:e21\u2013e26.","journal-title":"Am. J. Infect. Control."},{"key":"e_1_3_3_6_2","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1348-0421.2012.00481.x","article-title":"Characterization of MLS(b) resistance among Staphylococcus aureus and Staphylococcus epidermidis isolates carrying different SCCmec types","volume":"56","author":"Teodoro C.R.","year":"2012","unstructured":"Teodoro C.R., , Mattos C.S., , Cavalcante F.S., , Pereira E.M., , and Dos Santos K.R.N. 2012. Characterization of MLS(b) resistance among Staphylococcus aureus and Staphylococcus epidermidis isolates carrying different SCCmec types. Microbiol. Immunol., 56:647\u2013650.","journal-title":"Microbiol. 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