{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:42:38Z","timestamp":1779298958231,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>\n                    We investigated the implications of hypervirulence determinants on clinical features of 48 adult patients with bacteremia caused by extended-spectrum \u03b2-lactamase-producing\n                    <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                    . Isolates in the hypervirulence group included any of the following virulence determinants: K1\/K2 capsule serotypes, hypermucoviscosity phenotype,\n                    <jats:italic toggle=\"yes\">rmpA<\/jats:italic>\n                    gene, or\n                    <jats:italic toggle=\"yes\">rmpA2<\/jats:italic>\n                    gene. Nonhypervirulence group isolates were negative for all of the above virulence factors. In this study, all isolates used were non-K1\/K2 strains. Statistically significant differences were observed in clinical features of patients between the two groups. The hypervirulent isolates (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200919), including 11 isolates with the hypermucoviscosity phenotype, 15 with the\n                    <jats:italic toggle=\"yes\">rmpA<\/jats:italic>\n                    gene, and 16 with the\n                    <jats:italic toggle=\"yes\">rmpA2<\/jats:italic>\n                    gene, were more commonly recovered from diabetic patients and mainly manifested as secondary bacteremia (such as pneumonia, urinary tract infections, or other localized infections). The nonhypervirulent isolates (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200929) were more commonly recovered from patients after prolonged hospital stays (&gt;30 days) and mostly manifested as primary bacteremia. The overall in-hospital mortality was 56.3%. Hazard ratio (HR) analysis revealed the following positive predictors for mortality: nosocomial infection, stay in an intensive care unit, no removal of the central venous catheter, Charlson comorbidity score, and APACHE II score (\u226715). The negative predictors were initial appropriate antibiotic therapy (HR 0.42) and urinary tract infection (HR 0.19). Charlson score was an independent confounder based on multivariate analysis (HR 1.43, 95% confidence interval 1.04\u20131.99). In conclusion, hypervirulence determinants played a role in causing secondary infections in diabetic patients; however, the presence of morbidity cofactors could themselves influence mortality, despite the absence of hypervirulence determinants.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2016.0018","type":"journal-article","created":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T16:36:13Z","timestamp":1467736573000},"page":"376-383","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Impacts of Hypervirulence Determinants on Clinical Features and Outcomes of Bacteremia Caused by Extended-Spectrum \u03b2-Lactamase-Producing\n                    <i>Klebsiella pneumoniae<\/i>"],"prefix":"10.1177","volume":"23","author":[{"given":"Wen-Liang","family":"Yu","sequence":"first","affiliation":[{"name":"Chi Mei Medical Center","place":["Taiwan"]},{"name":"Taipei Medical University","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Feng","family":"Lee","sequence":"additional","affiliation":[{"name":"Chi Mei Medical Center","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Chung","family":"Chen","sequence":"additional","affiliation":[{"name":"Chi Mei Medical Center","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung-Jen","family":"Tang","sequence":"additional","affiliation":[{"name":"Chi Mei Medical Center","place":["Taiwan"]},{"name":"Chia Nan University of Pharmacy and Science","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Han","family":"Ho","sequence":"additional","affiliation":[{"name":"Chi Mei Medical Center","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin-Ching","family":"Chuang","sequence":"additional","affiliation":[{"name":"Chi Mei Medical Center","place":["Taiwan"]},{"name":"Chi Mei Medical Center-Liou Ying","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,4]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/503420"},{"key":"e_1_3_4_3_2","first-page":"311","article-title":"Clinical spectrum and molecular characteristics of Klebsiella pneumoniae causing community-acquired extrahepatic abscess","volume":"41","author":"Ku Y.H.","year":"2008","unstructured":"Ku Y.H., , Chuang Y.C., , and Yu W.L.. 2008. 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