{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T22:10:31Z","timestamp":1794262231311,"version":"4.9.0"},"reference-count":48,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T00:00:00Z","timestamp":1466121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T00:00:00Z","timestamp":1466121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2016,10,1]]},"abstract":"<jats:p>\n                    We characterized extended-spectrum beta-lactamases (ESBLs) and plasmid-mediated quinolone resistance (PMQR) in 32\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    extended spectrum cephalosporin (ESC)-resistant clinical isolates from UK companion animals from several clinics. In addition, to investigate the possible dissemination of ESBL clinical isolates within a veterinary hospital, two ESBL-producing\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    isolates from a dog with septic peritonitis and a cluster of environmental ESC-resistant\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    isolates obtained from the same clinic and during the same time period, as these two particular ESBL-positive clinical isolates, were also included in the study. Molecular characterization identified\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CTX-M<\/jats:sub>\n                    to be the most prevalent gene in ESC-resistant isolates, where 66% and 27% of clinical isolates carried\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CTX-M-15<\/jats:sub>\n                    and\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CTX-M-14,<\/jats:sub>\n                    respectively. The only PMQR gene detected was\n                    <jats:italic toggle=\"yes\">aac(6')-Ib<\/jats:italic>\n                    -\n                    <jats:italic toggle=\"yes\">cr<\/jats:italic>\n                    , being found in 34% of the ESC\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    isolates and was associated with the carriage of\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CTX-M-15<\/jats:sub>\n                    . The clinical and environmental isolates investigated for hospital dissemination had a common ESBL\/AmpC phenotype, carried\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CTX-M-15<\/jats:sub>\n                    , and co-harbored\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA-1,<\/jats:sub>\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>TEM-1,<\/jats:sub>\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CMY-2,<\/jats:sub>\n                    and\n                    <jats:italic toggle=\"yes\">aac(6')-Ib<\/jats:italic>\n                    -\n                    <jats:italic toggle=\"yes\">cr.<\/jats:italic>\n                    Multilocus sequence typing identified them all as ST410, while pulse-field gel electrophoresis demonstrated 100% homology of clinical and environmental isolates, suggesting hospital environmental dissemination of CTX-M-15\u2013producing\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    ST410.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2016.0036","type":"journal-article","created":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T16:47:10Z","timestamp":1466182030000},"page":"609-615","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":51,"title":["Veterinary Hospital Dissemination of CTX-M-15 Extended-Spectrum Beta-Lactamase\u2013Producing\n                    <i>Escherichia coli<\/i>\n                    ST410 in the United Kingdom"],"prefix":"10.1177","volume":"22","author":[{"given":"Dorina","family":"Timofte","sequence":"first","affiliation":[{"name":"University of Liverpool","place":["United Kingdom"]},{"name":"University of Liverpool","place":["United Kingdom"]},{"name":"University of Agronomical Sciences and Veterinary Medicine","place":["Romania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iuliana Elena","family":"Maciuca","sequence":"additional","affiliation":[{"name":"University of Liverpool","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola J.","family":"Williams","sequence":"additional","affiliation":[{"name":"University of Liverpool","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Wattret","sequence":"additional","affiliation":[{"name":"University of Liverpool","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Schmidt","sequence":"additional","affiliation":[{"name":"University of Liverpool","place":["United Kingdom"]},{"name":"University of Liverpool","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,6,17]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2010.11.013"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh332"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks049"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2012.10.029"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.2.833-835.2005"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm474"},{"key":"e_1_3_2_8_2","first-page":"94","article-title":"Extended-spectrum beta-lactamases-producing Gram-negative bacteria in companion animals: action is clearly warranted! 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