{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:26:35Z","timestamp":1777922795328,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>\n                    Since the implementation of routine PCV13 immunization in Japan, nonvaccine serotypes (NVTs) have been increasing among clinical isolates of\n                    <jats:italic toggle=\"yes\">Streptococcus pneumoniae<\/jats:italic>\n                    . In this study, susceptibility to 18 antibiotics was tested for all the 231 isolates with NVTs, which were collected from children &lt;16 years of age in northern Japan in 2014 (July\u2013November). High resistance rates were observed for macrolides (&gt;90.9%), tetracycline (91.3%), and clindamycin (75.3%), while penicillin (PEN) nonsusceptibility (PNSP; MIC \u22650.12\u2009\u03bcg\/ml) was detected in 42.9% of the pneumococci [39.4%; PEN-intermediate\n                    <jats:italic toggle=\"yes\">S. pneumoniae<\/jats:italic>\n                    (PISP), 3.5%; PEN-resistant\n                    <jats:italic toggle=\"yes\">S. pneumoniae<\/jats:italic>\n                    (PRSP)]. All serotype 15A isolates were PRSP (MIC, \u22652\u2009\u03bcg\/ml) or PISP, and PNSP was prevalent in also serotypes 23A (96.9%), 6C (41%), and 35B (33.3%). Overall, 42.0% of the isolates showed multidrug resistance (MDR). Sequence types (STs) determined for 20 PNSP isolates with NVTs were ST63 (15A), STs 242 or 5832 (6C), STs 338 or 5242 (23A), and ST558 (35B). All the PNSP isolates possessed\n                    <jats:italic toggle=\"yes\">tet(M)<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">erm(B)<\/jats:italic>\n                    or\n                    <jats:italic toggle=\"yes\">mefA(A\/E)<\/jats:italic>\n                    , and 70% of them were gPRSP having three altered genes\n                    <jats:italic toggle=\"yes\">pbp1a<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">pbp2x<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">pbp2b<\/jats:italic>\n                    . Among alterations in transpeptidase-coding region of penicillin-binding proteins (PBPs), two substitutions of T\n                    <jats:sub>371<\/jats:sub>\n                    S in the STMK motif and TSQF\n                    <jats:sub>574\u2013577<\/jats:sub>\n                    NTGY in PBP1a were common to all PRSP isolates. The present study showed the spread of PNSP in NVTs 15A, 23A, 6C, and 35B, and the emergence of the MDR international clone Sweden\n                    <jats:sup>15A<\/jats:sup>\n                    -ST63 in northern Japan.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2016.0054","type":"journal-article","created":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T16:18:06Z","timestamp":1464970686000},"page":"206-214","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Multidrug Resistance in Non-PCV13 Serotypes of\n                    <i>Streptococcus pneumoniae<\/i>\n                    in Northern Japan, 2014"],"prefix":"10.1177","volume":"23","author":[{"given":"Mitsuyo","family":"Kawaguchiya","sequence":"first","affiliation":[{"name":"Sapporo Medical University School of Medicine","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Urushibara","sequence":"additional","affiliation":[{"name":"Sapporo Medical University School of Medicine","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobumichi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Sapporo Medical University School of Medicine","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,3]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.08.010"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"6484","DOI":"10.1128\/AAC.03344-14","article-title":"Changes in pneumococcal serotypes and antimicrobial resistance after introduction of the 13-valent conjugate vaccine in the United States","volume":"58","author":"Richter S.S.","year":"2014","unstructured":"Richter S.S., , Diekema D.J., , Heilmann K.P., , Dohrn C.L., , Riahi F., , and Doern G.V.. 2014. 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