{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T09:27:40Z","timestamp":1779010060338,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>\n                    A strictly defined subset of gonococci (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200965) isolated in Italy from 2011 to 2014 was characterized by antimicrobial susceptibility for cefixime (CFM) and ceftriaxone (CRO) and by sequencing of resistance determinant genes (\n                    <jats:italic toggle=\"yes\">penA<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">mtrR<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">porB1b<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">ponA<\/jats:italic>\n                    ) for extended-spectrum cephalosporins and\n                    <jats:italic toggle=\"yes\">Neisseria gonorrhoeae<\/jats:italic>\n                    multiantigen sequence typing (NG-MAST). The\n                    <jats:italic toggle=\"yes\">penA<\/jats:italic>\n                    mosaic alleles XXXIV and XXXV were found in all resistant (R) and decreased susceptibility (DS) gonococci to CFM, except for one. They were associated with an adenine deletion in the\n                    <jats:italic toggle=\"yes\">mtrR<\/jats:italic>\n                    promoter plus amino acid substitutions, H105Y or G45D, in the coding region and\n                    <jats:italic toggle=\"yes\">ponA<\/jats:italic>\n                    L421P. The\n                    <jats:italic toggle=\"yes\">penA<\/jats:italic>\n                    mosaic allele XXXIV, and one variant, was found exclusively among genogroup (G) 1407 and its closely related sequence types (STs), as in CFM-DS as well as in CFM-R isolates. Single or combined mutation patterns in\n                    <jats:italic toggle=\"yes\">penA<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">mtrR<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">porB1b<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">ponA<\/jats:italic>\n                    genes were associated with different CFM susceptibility patterns and NG-MAST STs. Genotyping and antimicrobial resistance (AMR) determinant analyses can be valuable to enhance the gonococcal AMR surveillance.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2016.0086","type":"journal-article","created":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T16:19:36Z","timestamp":1467044376000},"page":"247-252","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Genetic Resistance Determinants for Cefixime and Molecular Analysis of Gonococci Isolated in Italy"],"prefix":"10.1177","volume":"23","author":[{"given":"Anna","family":"Carannante","sequence":"first","affiliation":[{"name":"Istituto Superiore di Sanit\u00e0","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Vacca","sequence":"additional","affiliation":[{"name":"Istituto Superiore di Sanit\u00e0","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Ghisetti","sequence":"additional","affiliation":[{"name":"Amedeo di Savoia Hospital","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Agnese","family":"Latino","sequence":"additional","affiliation":[{"name":"Citt\u00e0 della Salute e della Scienza di Torino","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Cusini","sequence":"additional","affiliation":[{"name":"Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Matteelli","sequence":"additional","affiliation":[{"name":"University of Brescia","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Vocale","sequence":"additional","affiliation":[{"name":"University Hospital","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grazia","family":"Prignano","sequence":"additional","affiliation":[{"name":"San Gallicano Dermatologic Institute","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Leli","sequence":"additional","affiliation":[{"name":"University of Perugia","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Ober","sequence":"additional","affiliation":[{"name":"\u201cSanta Chiara Hospital","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Antonetti","sequence":"additional","affiliation":[{"name":"\u201cAzienda Ospedaliero-Universitaria OORR,\u201d","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Poletti","sequence":"additional","affiliation":[{"name":"\u201cOspedali Castelli ASL VCO,\u201d","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Stefanelli","sequence":"additional","affiliation":[{"name":"Istituto Superiore di Sanit\u00e0","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,3]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"World Health Organisation (WHO). 2012. 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