{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:25:35Z","timestamp":1791048335066,"version":"4.1.0"},"reference-count":71,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2017,3]]},"abstract":"\n Sixteen broad-spectrum cephalosporin-resistant\n Klebsiella pneumoniae<\/jats:italic>\n isolates were recovered between April and June 2013 from Palestinian hospitals, Gaza Strip. Genes encoding extended-spectrum beta-lactamases (ESBLs) and other resistance genes were characterized by polymerase chain reaction and sequencing. The following \u03b2-lactamase genes were detected:\n bla<\/jats:italic>\n CTX-M-15<\/jats:sub>\n +\n bla<\/jats:italic>\n SHV1<\/jats:sub>\n +\n bla<\/jats:italic>\n TEM-1<\/jats:sub>\n (six isolates),\n bla<\/jats:italic>\n CTX-M-15<\/jats:sub>\n +\n bla<\/jats:italic>\n SHV5<\/jats:sub>\n +\n bla<\/jats:italic>\n OXA-1<\/jats:sub>\n (two isolates),\n bla<\/jats:italic>\n CTX-M-14a<\/jats:sub>\n (two isolates),\n bla<\/jats:italic>\n CTX-M-15<\/jats:sub>\n +\n bla<\/jats:italic>\n SHV33<\/jats:sub>\n (one isolate),\n bla<\/jats:italic>\n CTX-M-15<\/jats:sub>\n +\n bla<\/jats:italic>\n TEM-1<\/jats:sub>\n (one isolate),\n bla<\/jats:italic>\n CTX-M-15<\/jats:sub>\n +\n bla<\/jats:italic>\n SHV12<\/jats:sub>\n +\n bla<\/jats:italic>\n OXA-1<\/jats:sub>\n (one isolate),\n bla<\/jats:italic>\n CTX-M-15<\/jats:sub>\n +\n bla<\/jats:italic>\n SHV5<\/jats:sub>\n (one isolate),\n bla<\/jats:italic>\n CTX-M-15<\/jats:sub>\n +\n bla<\/jats:italic>\n SHV1<\/jats:sub>\n (one isolate), and\n bla<\/jats:italic>\n CTX-M-3<\/jats:sub>\n (one isolate). The IS\n Ecp1<\/jats:italic>\n (in four cases truncated by IS\n 26<\/jats:italic>\n ),\n orf477<\/jats:italic>\n , or IS\n 903<\/jats:italic>\n sequences were found upstream or downstream of\n bla<\/jats:italic>\n CTX-M<\/jats:sub>\n genes. The\n aac<\/jats:italic>\n (6\u2032)-Ib-cr gene was found in seven isolates. The\n qnrS1<\/jats:italic>\n and\n qnrB1<\/jats:italic>\n genes were detected in five isolates and two isolates, respectively. Seven isolates contained class 1 integrons with four gene cassette arrangements:\n dfrA5<\/jats:italic>\n (three isolates),\n dfrA12<\/jats:italic>\n -\n orf<\/jats:italic>\n -\n aadA2<\/jats:italic>\n (two isolates),\n dfrA17<\/jats:italic>\n -\n aadA5<\/jats:italic>\n (one isolate), and\n aadA1<\/jats:italic>\n (one isolate). A high clonal diversity was also observed among studied isolates by pulsed-field gel electrophoresis (12 unrelated profiles). This study demonstrates for the first time the emergence and polyclonal spread of multidrug-resistant ESBL\u2013producing\n K. pneumoniae<\/jats:italic>\n isolates among patients in a hospital setting in Gaza Strip, Palestine.\n <\/jats:p>","DOI":"10.1089\/mdr.2016.0089","type":"journal-article","created":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T18:57:47Z","timestamp":1465844267000},"page":"169-176","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["First Report of Extended-Spectrum \u03b2-Lactamases Among Clinical Isolates of\n Klebsiella pneumoniae<\/i>\n in Gaza Strip, Palestine"],"prefix":"10.1177","volume":"23","author":[{"given":"Ghassan","family":"Tayh","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Tunis-El Manar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rym","family":"Ben Sallem","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Tunis-El Manar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houssem","family":"Ben Yahia","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Tunis-El Manar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haythem","family":"Gharsa","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Tunis-El Manar"},{"name":"Universit\u00e9 de Tunis El-Manar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naouel","family":"Klibi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Tunis-El Manar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdellatif","family":"Boudabous","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Tunis-El Manar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Ben Slama","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Tunis-El Manar"},{"name":"Universit\u00e9 de Tunis El-Manar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,3]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.11.4.589"},{"key":"e_1_3_2_3_2","first-page":"1479","article-title":"Characterization of extended-spectrum \u03b2-lactamases (ESBLs) producers in K. pneumoniae by genotypic and phenotypic method","volume":"20","author":"Puspanadan S.","year":"2013","unstructured":"Puspanadan S., , Hejri L., , John Y., , Rukayadi Y., , Loo Y., , Nillian E., , Kuan C., , Goh S., , Chang W., , Lye Y., , Mohd N., , Yoshitsugu N., , Nishibuchi M., , and Son R. 2013. 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