{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:26:54Z","timestamp":1777922814305,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T00:00:00Z","timestamp":1484265600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2017,9,1]]},"abstract":"<jats:p>\n                    Difference in the development of resistance may be associated with the epidemiological spread and drug resistance of different\n                    <jats:italic toggle=\"yes\">Salmonella enterica<\/jats:italic>\n                    serovar strains. In the present study, three susceptible\n                    <jats:italic toggle=\"yes\">S. enterica<\/jats:italic>\n                    serovars, Typhimurium (ST), Enteritidis (SE), and Indiana (SI) strains, were subjected to stepwise selection with increasing ciprofloxacin concentrations. The results indicated that the mutation frequencies of the SI group were 10\n                    <jats:sup>1<\/jats:sup>\n                    \u201310\n                    <jats:sup>4<\/jats:sup>\n                    higher and developed resistance to ciprofloxacin more rapidly compared with the ST and SE groups. Ciprofloxacin accumulation in the SI strain was also higher than the other two strains in the presence of an efflux pump inhibitor. The development of ciprofloxacin resistance was quite different among the three serovar strains. In SI, increasing AcrAB-TolC efflux pump expression and single or double mutations in\n                    <jats:italic toggle=\"yes\">gyrA<\/jats:italic>\n                    with or without a single\n                    <jats:italic toggle=\"yes\">parC<\/jats:italic>\n                    mutation (T57S) were found in the development of ciprofloxacin resistance. In SE, an increase in the AcrAB-TolC efflux pump regulatory gene\n                    <jats:italic toggle=\"yes\">ramA<\/jats:italic>\n                    gradually decreased as resistant bacteria developed; then resistance resulted from\n                    <jats:italic toggle=\"yes\">gyrA<\/jats:italic>\n                    D87G and\n                    <jats:italic toggle=\"yes\">gyrB<\/jats:italic>\n                    E466D mutations and\/or in other active efflux pumps besides AcrAB-TolC. For ST,\n                    <jats:italic toggle=\"yes\">ramA<\/jats:italic>\n                    expression increased rapidly along with\n                    <jats:italic toggle=\"yes\">gyrA<\/jats:italic>\n                    D87\u2009N and\/or\n                    <jats:italic toggle=\"yes\">gyrB<\/jats:italic>\n                    S464F mutations. In conclusion, persistent use of ciprofloxacin may aggravate the resistance of different\n                    <jats:italic toggle=\"yes\">S. enterica<\/jats:italic>\n                    serovars and prudent use of the fluoroquinolones is needed. The quicker resistance and higher mutation frequency of the SI isolates present a potential public health threat.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2016.0119","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T16:10:57Z","timestamp":1484323857000},"page":"687-694","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["<i>In Vitro<\/i>\n                    Development of Ciprofloxacin Resistance of\n                    <i>Salmonella enterica<\/i>\n                    Serovars Typhimurium, Enteritidis, and Indiana Isolates from Food Animals"],"prefix":"10.1177","volume":"23","author":[{"given":"Wen-Hui","family":"Zhang","sequence":"first","affiliation":[{"name":"South China Agricultural University (SCAU)","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan-Zhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"South China Agricultural University (SCAU)","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"South China Agricultural University (SCAU)","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi-Xi","family":"Gu","sequence":"additional","affiliation":[{"name":"South China Agricultural University (SCAU)","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan","family":"Li","sequence":"additional","affiliation":[{"name":"South China Agricultural University (SCAU)","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Yang","sequence":"additional","affiliation":[{"name":"South China Agricultural University (SCAU)","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"South China Agricultural University (SCAU)","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-Ling","family":"Zeng","sequence":"additional","affiliation":[{"name":"South China Agricultural University (SCAU)","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Xia","family":"Jiang","sequence":"additional","affiliation":[{"name":"South China Agricultural University (SCAU)","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,1,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.20506\/rst.19.1.1219"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2005.02.013"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096050"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2013.00053"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00084-08"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023471"},{"key":"e_1_3_3_8_2","first-page":"418","article-title":"Preliminary FoodNet data on the incidence of infection with pathogens transmitted commonly through food-10 States, 2009","volume":"59","author":"[CDC] Centre for Disease prevention and Control","year":"2010","unstructured":"[CDC] Centre for Disease prevention and Control. 2010. 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