{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T19:40:47Z","timestamp":1779392447749,"version":"3.53.1"},"reference-count":59,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>\n                    Multidrug-resistant (MDR)\n                    <jats:italic toggle=\"yes\">Acinetobacter baumannii<\/jats:italic>\n                    has increasingly emerged as an important nosocomial pathogen. The aim of this study was to determine the resistance profiles and genetic diversity in\n                    <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                    clinical isolates in a tertiary medical center in Malaysia. The minimum inhibitory concentrations of carbapenems (imipenem and meropenem), cephalosporins (ceftazidime and cefepime), and ciprofloxacin were determined by E-test. PCR and sequencing were carried out for the detection of antibiotic resistance genes and mutations. Clonal relatedness among\n                    <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                    isolates was determined by REP-PCR. Sequence-based typing of OXA-51 and multilocus sequence typing were performed. One hundred twenty-five of 162 (77.2%)\n                    <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                    isolates had MDR phenotype. From the 162\n                    <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                    isolates, 20 strain types were identified and majority of\n                    <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                    isolates (66%,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u2009107) were classified as strain type 1 and were positive for IS\n                    <jats:italic toggle=\"yes\">Aba1<\/jats:italic>\n                    -\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA-23<\/jats:sub>\n                    and IS\n                    <jats:italic toggle=\"yes\">Aba1<\/jats:italic>\n                    -\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>ADC<\/jats:sub>\n                    and had mutations in both\n                    <jats:italic toggle=\"yes\">gyrA<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">parC<\/jats:italic>\n                    genes at positions, 83 and 80, resulting in serine-to-leucine conversion. REP-PCR analysis showed 129 REP types that generated 31 clones with a 90% similarity cutoff value. OXA-66 variant of the\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA-51-like<\/jats:sub>\n                    genes was predominantly detected among our\n                    <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                    clinical isolates belonging to ST195 (found in six clones: 1, 8, 9, 19, 27, and 30) and ST208 (found in clone 21). The study helps us in understanding the genetic diversity of\n                    <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                    isolates in our setting and confirms that international clone II is the most widely distributed clone in Universiti Kebangsaan Malaysia Medical Centre, Malaysia.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2016.0130","type":"journal-article","created":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T10:33:31Z","timestamp":1479378811000},"page":"545-555","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Antimicrobial Resistance Mechanisms and Genetic Diversity of Multidrug-Resistant\n                    <i>Acinetobacter baumannii<\/i>\n                    Isolated from a Teaching Hospital in Malaysia"],"prefix":"10.1177","volume":"23","author":[{"given":"Shirin","family":"Biglari","sequence":"first","affiliation":[{"name":"Universiti Kebangsaan Malaysia Medical Centre","place":["Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfizah","family":"Hanafiah","sequence":"additional","affiliation":[{"name":"Universiti Kebangsaan Malaysia Medical Centre","place":["Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaliawani","family":"Mohd Puzi","sequence":"additional","affiliation":[{"name":"Universiti Kebangsaan Malaysia Medical Centre","place":["Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramliza","family":"Ramli","sequence":"additional","affiliation":[{"name":"Universiti Kebangsaan Malaysia Medical Centre","place":["Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafizur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Universiti Kebangsaan Malaysia Medical Centre","place":["Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Silvester","family":"Lopes","sequence":"additional","affiliation":[{"name":"University of Aberdeen","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1186\/1471-2164-15-1163","article-title":"Comparative genomic analysis of Acinetobacter baumannii clinical isolates reveals extensive genomic variation and diverse antibiotic resistance determinants","volume":"15","author":"Liu F.","year":"2014","unstructured":"Liu F., , Zhu Y., , Yi Y., , Lu N., , Zhu B., , and Hu Y.. 2014. Comparative genomic analysis of Acinetobacter baumannii clinical isolates reveals extensive genomic variation and diverse antibiotic resistance determinants. BMC Genomics, 15:1163.","journal-title":"BMC Genomics"},{"issue":"1","key":"e_1_3_3_3_2","first-page":"S7","article-title":"Progress and challenges in implementing the research on ESKAPE pathogens","volume":"31","author":"Rice L.B.","year":"2014","unstructured":"Rice L.B. 2014. Progress and challenges in implementing the research on ESKAPE pathogens. Infect. Control Hosp. Epidemiol., 31,(Suppl 1)::S7\u2013S10.","journal-title":"Infect. Control Hosp. 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Porins, efflux pumps and multidrug-resistance in Acinetobacter baumanii. J. Antimicrob. Chemother., 59:1210\u20131215.","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq095"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001805"},{"key":"e_1_3_3_9_2","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1128\/JCM.01021-06","article-title":"Identification of Acinetobacter baumannii by detection of the bla\n                  OXA-51-like carbapenemase gene intrinsic to this species","volume":"44","author":"Turton J.F.","year":"2006","unstructured":"Turton J.F., , Woodford N., , Glover J., , Yarde S., , Kaufmann M.E., . and Pitt T.L.. 2006. Identification of Acinetobacter baumannii by detection of the blaOXA-51-like carbapenemase gene intrinsic to this species. J. Clin. Microbiol., 44:974\u2013976.","journal-title":"J. Clin. 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