{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:11:44Z","timestamp":1788372704289,"version":"build-2803163510"},"reference-count":35,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>\n                      In this study, we analyzed the molecular epidemiology of extended-spectrum \u03b2-lactamase (ESBL)-producing\n                      <jats:italic toggle=\"yes\">Proteus mirabilis<\/jats:italic>\n                      isolates collected from the central region of Japan.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Between 2005 and 2012, 820 clinical\n                      <jats:italic toggle=\"yes\">P. mirabilis<\/jats:italic>\n                      isolates were obtained from ten acute care hospitals in Japan. We characterized ESBL confirmatory test-positive isolates by sequencing the ESBL genes and their flanking regions, detecting plasmid replicons, and performing pulsed-field gel electrophoresis (PFGE).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Ninety-six isolates (12%) were positive according to the ESBL confirmatory test; all these isolates possessed\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>CTX-M-2<\/jats:sub>\n                      with the same flanking structure of upstream \u0394IS\n                      <jats:italic toggle=\"yes\">Ecp1<\/jats:italic>\n                      and a downstream region identical to downstream\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>KLUA-1<\/jats:sub>\n                      . IncT was the prevalent, and only, replicon found in 63 isolates. PFGE analysis detected eight clusters with more than one isolate, among which three included 56 isolates and six included isolates from multiple hospitals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      CTX-M-2-producing\n                      <jats:italic toggle=\"yes\">P. mirabilis<\/jats:italic>\n                      with an identical genetic structure flanking\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>CTX-M-2<\/jats:sub>\n                      is dominant in this Japanese region, and there is evidence for the clonal spread of isolates.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/mdr.2016.0148","type":"journal-article","created":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T11:56:47Z","timestamp":1478865407000},"page":"590-595","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Regional Spread of CTX-M-2-Producing\n                    <i>Proteus mirabilis<\/i>\n                    with the Identical Genetic Structure in Japan"],"prefix":"10.1177","volume":"23","author":[{"given":"Karin","family":"Kato","sequence":"first","affiliation":[{"name":"Kyoto University Graduate School of Medicine","place":["Japan"]},{"name":"Kyoto University Graduate School of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasufumi","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Kyoto University Graduate School of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Kyoto University Graduate School of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Nagao","sequence":"additional","affiliation":[{"name":"Kyoto University Graduate School of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunji","family":"Takakura","sequence":"additional","affiliation":[{"name":"Kyoto University Graduate School of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Ichiyama","sequence":"additional","affiliation":[{"name":"Kyoto University Graduate School of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00019-07"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jmii.2011.11.007","article-title":"Proteus mirabilis urinary tract infection and bacteremia: risk factors, clinical presentation, and outcomes","volume":"45","author":"Chen C.Y.","year":"2012","unstructured":"Chen C.Y., , Chen Y.H., , Lu P.L., , Lin W.R., , Chen T.C., , and Lin C.Y.. 2012. 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