{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T13:50:09Z","timestamp":1782136209762,"version":"3.54.5"},"reference-count":40,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T00:00:00Z","timestamp":1484611200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2017,9,1]]},"abstract":"\n Objectives:<\/jats:title>\n \n The current study aimed to investigate extended-spectrum \u03b2-lactamase-producing\n Enterobacteriaceae<\/jats:italic>\n (ESBL-\n E<\/jats:italic>\n ) fecal carriage in children with different cancers admitted in the pediatric oncology unit of Beni-Messous Hospital (Algiers, Algeria).\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n Rectal swabs from children with cancer were sampled from February 2012 to May 2013 within 48 hours following their admission. After species identification and detection of ESBL production by double-disk synergy test (DD test), antibiotic susceptibility was determined by the standard disk diffusion method. Antibiotic resistance genes, including\n bla<\/jats:italic>\n genes and plasmid-mediated quinolone resistance (PMQR) genes, were investigated by polymerase chain reaction (PCR). The phylogenetic grouping of\n Escherichia coli<\/jats:italic>\n strains was determined by PCR.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Of the 171 children studied, 93 (54%) were ESBL carriers. An antibiotic treatment for the last 3 months before admission (\n p<\/jats:italic>\n \u2009=\u20090.01), hematological malignancies (\n p<\/jats:italic>\n \u2009=\u20090.003), and death (\n p<\/jats:italic>\n \u2009=\u20090.0003) were more frequent in the ESBL-\n E<\/jats:italic>\n group than in the non-ESBL group. Multivariate analysis showed that hematological malignancies (odds ratio [OR]: 3.9; confidence interval [CI]: 1.1\u201314.1;\n p<\/jats:italic>\n \u2009=\u20090.04) and ESBL-\n E<\/jats:italic>\n carriage (OR: 6.2; CI: 1.7\u201322.00;\n p<\/jats:italic>\n \u2009=\u20090.005) were two independent factors associated with increased risk of death. A total of 103 ESBL-\n E<\/jats:italic>\n isolates were obtained.\n Klebsiella pneumoniae<\/jats:italic>\n and\n E. coli<\/jats:italic>\n isolates were the most frequently isolated. PCR amplification showed that all the isolates produced a CTX-M ESBL (CTX-M-15, CTX-M-14, and CTX-M-3). The PMQR genes detected were\n qnrB<\/jats:italic>\n ,\n qnrS<\/jats:italic>\n , and\n aac(6\u2032)-Ib-cr<\/jats:italic>\n .\n E. coli<\/jats:italic>\n isolates were assigned to four major extraintestinal pathogenic\n E. coli<\/jats:italic>\n phylogroups, including B2 and D.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n This study provides, for the first time, insight into epidemiology of the ESBL-\n E<\/jats:italic>\n fecal carriage among children with cancer in Algeria.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1089\/mdr.2016.0153","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T12:43:39Z","timestamp":1484657019000},"page":"757-763","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Fecal Carriage of Extended-Spectrum \u03b2-Lactamase-Producing\n Enterobacteriaceae<\/i>\n Strains Is Associated with Worse Outcome in Patients Hospitalized in the Pediatric Oncology Unit of Beni-Messous Hospital in Algiers, Algeria"],"prefix":"10.1177","volume":"23","author":[{"given":"Chafiaa","family":"Medboua-Benbalagh","sequence":"first","affiliation":[{"name":"Laboratoire d'Ecologie Microbienne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelaziz","family":"Touati","sequence":"additional","affiliation":[{"name":"Laboratoire d'Ecologie Microbienne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachida","family":"Kermas","sequence":"additional","affiliation":[{"name":"Laboratoire d'Ecologie Microbienne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alima","family":"Gharout-Sait","sequence":"additional","affiliation":[{"name":"Laboratoire d'Ecologie Microbienne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucien","family":"Brasme","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie\u2013Virologie-Hygi\u00e8ne Hospitali\u00e8re","place":["France"]},{"name":"Universit\u00e9 de Reims-Champagne-Ardenne","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halima","family":"Mezhoud","sequence":"additional","affiliation":[{"name":"Laboratoire d'Ecologie Microbienne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djamila","family":"Touati","sequence":"additional","affiliation":[{"name":"Laboratoire M\u00e8re et Enfant"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Guillard","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie\u2013Virologie-Hygi\u00e8ne Hospitali\u00e8re","place":["France"]},{"name":"Universit\u00e9 de Reims-Champagne-Ardenne","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"de Champs","sequence":"additional","affiliation":[{"name":"Laboratoire de Bact\u00e9riologie\u2013Virologie-Hygi\u00e8ne Hospitali\u00e8re","place":["France"]},{"name":"Universit\u00e9 de Reims-Champagne-Ardenne","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,1,17]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu612"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2013.189"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-015-2772-z"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-0711-13-22"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2015.11.001"},{"key":"e_1_3_3_7_2","first-page":"68","article-title":"A case-control study of risk factors associated with rectal colonization of extended-spectrum beta-lactamase producing Klebsiella sp","volume":"61","author":"Boo N.Y.","year":"2005","unstructured":"Boo N.Y., , Ng S.F., , and Lim V.K.. 2005. 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