{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:27:08Z","timestamp":1777922828031,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2017,7]]},"abstract":"\n Aim:<\/jats:title>\n \n To perform a retrospective analysis of the high occurrence of\n Clostridium difficile<\/jats:italic>\n infection in the surgical department of a Czech tertiary care hospital and to identify weaknesses in\n C. difficile<\/jats:italic>\n infection (CDI) prevention and control policies.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n Clinical and epidemiological data on eleven CDI cases were collected.\n C. difficile<\/jats:italic>\n isolates were characterized by capillary electrophoresis ribotyping, multilocus variable tandem repeat analysis (MLVA),\n gyrA<\/jats:italic>\n gene fragment sequencing, and\n erm<\/jats:italic>\n (B) fragment PCR amplification. Antibiotic susceptibility to metronidazole, vancomycin, ciprofloxacin, moxifloxacin, and clindamycin was tested.\n <\/jats:p>\n <\/jats:sec>\n \n Findings:<\/jats:title>\n \n Eleven CDI cases were caused by\n C. difficile<\/jats:italic>\n PCR ribotype 001 strains. These strains revealed two different MLVA profiles with 11 tandem repeat differences. All isolates were susceptible to metronidazole and vancomycin and resistant to ciprofloxacin (MIC \u226532\u2009mg\/L), moxifloxacin (MIC \u226532\u2009mg\/L), and clindamycin (MIC \u2265256\u2009mg\/L). All isolates revealed amino acid substitution Thr82Ile, in the GyrA and were\n erm<\/jats:italic>\n (B) negative.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n Two fluoroquinolone and clindamycin-resistant\n C. difficile<\/jats:italic>\n PCR ribotype 001 strain clusters occurred at one of the surgical departments of a tertiary care hospital. Ineffective decontamination with suboptimal concentration and time of exposure of sporicidal disinfectants may have resulted in\n C. difficile<\/jats:italic>\n transmission.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1089\/mdr.2016.0159","type":"journal-article","created":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T14:23:55Z","timestamp":1479479035000},"page":"609-615","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Two Clusters of Fluoroquinolone and Clindamycin-Resistant\n Clostridium difficile<\/i>\n PCR Ribotype 001 Strain Recognized by Capillary Electrophoresis Ribotyping and Multilocus Variable Tandem Repeat Analysis"],"prefix":"10.1177","volume":"23","author":[{"given":"Otakar","family":"Nyc","sequence":"first","affiliation":[{"name":"Charles University in Prague and Motol University Hospital","place":["Czech Republic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Tejkalova","sequence":"additional","affiliation":[{"name":"Masaryk University","place":["Czech Republic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zdenek","family":"Kriz","sequence":"additional","affiliation":[{"name":"Masaryk University","place":["Czech Republic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filip","family":"Ruzicka","sequence":"additional","affiliation":[{"name":"Masaryk University","place":["Czech Republic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lubos","family":"Kubicek","sequence":"additional","affiliation":[{"name":"Masaryk University","place":["Czech Republic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Matejkova","sequence":"additional","affiliation":[{"name":"Charles University in Prague and Motol University Hospital","place":["Czech Republic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ed","family":"Kuijper","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre","place":["Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Krutova","sequence":"additional","affiliation":[{"name":"Charles University in Prague and Motol University Hospital","place":["Czech Republic"]},{"name":"Charles University in Prague and Motol University Hospital","place":["Czech Republic"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,7]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00082-09"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000332946"},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"475","DOI":"10.2217\/fmb.14.2","article-title":"Clostridium difficile spores: a major threat to the hospital environment","volume":"9","author":"Barra-Carrasco J.","year":"2014","unstructured":"Barra-Carrasco J., , and Paredes-Sabja D.. 2014. 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