{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:36:46Z","timestamp":1790339806738,"version":"4.1.0"},"reference-count":48,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T00:00:00Z","timestamp":1487721600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2017,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>\n                      The aim of this study was to characterize two carbapenem-resistant\n                      <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                      isolates recovered from urine samples in a patient hospitalized at Annaba University hospital (Algeria) in 2014.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Two\n                      <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                      isolates were studied because they proved resistant to almost all antibiotics tested with a high level resistance to ertapenem (minimum inhibitory concentration\u2009=\u200932\u2009mg\/L). The results of modified Hodge test and combined disk test (ROSCO Diagnostica, Taastrup, Denmark) were positive. The two isolates harbored the\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>NDM-1<\/jats:sub>\n                      gene and one was also positive for\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>CTX-M-15<\/jats:sub>\n                      . Screening of aminoglycoside-modifying enzymes and plasmid-mediated quinolone resistance contents detected\n                      <jats:italic toggle=\"yes\">aac<\/jats:italic>\n                      (6\u2032)-\n                      <jats:italic toggle=\"yes\">Ib<\/jats:italic>\n                      -\n                      <jats:italic toggle=\"yes\">cr<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">aac(3\u2032)-II<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">qnrB2,<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">oqxAB<\/jats:italic>\n                      in both isolates. Multilocus sequence typing demonstrated that the two isolates belonged to sequence type 147. However, repetitive sequence-based PCR and pulsed-field gel electrophoresis showed that they were not clonally related. The\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>NDM-1<\/jats:sub>\n                      gene and all other resistant genes were contained on an IncR plasmid of\n                      <jats:italic toggle=\"yes\">c.a.<\/jats:italic>\n                      85\u2009kb.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      This study comprises the first identification of NDM-1-producing\n                      <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                      in Algeria. We thus confirm the concerning worldwide dissemination of this carbapenemase that involves the emergence of the IncR plasmid and the success of the ST147 clonal complex harboring it.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/mdr.2016.0213","type":"journal-article","created":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T12:07:00Z","timestamp":1487765220000},"page":"895-900","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["First Case of NDM-1-Producing\n                    <i>Klebsiella pneumoniae<\/i>\n                    in Annaba University Hospital, Algeria"],"prefix":"10.1177","volume":"23","author":[{"given":"Amel","family":"Abderrahim","sequence":"first","affiliation":[{"name":"UFR de M\u00e9decine","place":["France"]},{"name":"Universit\u00e9 Badji 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