{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:36:49Z","timestamp":1790181409194,"version":"4.1.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Acinetobacter baumannii<\/jats:italic>\n                    is an emerging nosocomial pathogen with also emerging resistance to different antibiotics. Multidrug and pan drug-resistant clinical isolates were reported worldwide. Here we report the first evidence of pan drug-resistant environmental isolate of\n                    <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                    . The isolate was recovered from the effluent of secondary treated municipal wastewater of the City of Zagreb, Croatia. The isolate was resistant to penicillins\/\u03b2-lactamase inhibitors, carbapenems, fluoroquinolones, aminoglycosides, folate pathway inhibitors, and polymyxins, except intermediately susceptible to minocycline and tigecycline. Intrinsic chromosomally located\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA-51-like<\/jats:sub>\n                    gene and acquired plasmid-located\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA-23-like<\/jats:sub>\n                    gene were related to clinical isolates. Pan drug-resistant\n                    <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                    can occur in natural environments outside of the hospital. Secondary treated municipal wastewater represents a potential epidemiological reservoir of pan drug-resistant\n                    <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                    and carbapenem resistance gene.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2016.0229","type":"journal-article","created":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T14:54:17Z","timestamp":1477666457000},"page":"494-496","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":39,"title":["Pan Drug-Resistant Environmental Isolate of\n                    <i>Acinetobacter baumannii<\/i>\n                    from Croatia"],"prefix":"10.1177","volume":"23","author":[{"given":"Ivana","family":"Goic-Barisic","sequence":"first","affiliation":[{"name":"University of Split School of Medicine","place":["Croatia"]},{"name":"University Hospital Centre Split","place":["Croatia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Seruga Music","sequence":"additional","affiliation":[{"name":"University of Zagreb","place":["Croatia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Kovacic","sequence":"additional","affiliation":[{"name":"Institute of Public Health of Split and Dalmatia County","place":["Croatia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Tonkic","sequence":"additional","affiliation":[{"name":"University of Split School of Medicine","place":["Croatia"]},{"name":"University Hospital Centre Split","place":["Croatia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasna","family":"Hrenovic","sequence":"additional","affiliation":[{"name":"University of Zagreb","place":["Croatia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,6]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/529198"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2009.03.032"},{"key":"e_1_3_4_4_2","article-title":"Step aside, MRSA, here comes Acinetobacter","author":"Wachter K.","year":"2006","unstructured":"Wachter K. 2006. Step aside, MRSA, here comes Acinetobacter. OB. GYN. News. January 15.","journal-title":"OB. GYN. News."},{"key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1128\/AAC.45.3.994-995.2001","article-title":"Polymyxin B-resistant Acinetobacter baumannii clinical isolate susceptible to recombinant BPI and cecropin P1","volume":"45","author":"Urban C.","year":"2001","unstructured":"Urban C., , Mariano N., , Rahal J.J., , Tay E., , Ponio C., , Koprivnjak T., , and Weiss J.. 2001. Polymyxin B-resistant Acinetobacter baumannii clinical isolate susceptible to recombinant BPI and cecropin P1. Antimicrob. Agents Chemother., 45:994\u2013995.","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1093\/jac\/dku170","article-title":"Detection of pan drug-resistant Acinetobacter baumannii in Germany","volume":"69","author":"G\u00f6ttig S.","year":"2014","unstructured":"G\u00f6ttig S., , Gruber T.M., , Higgins P.G., , Wachsmuth M., , Seifert H., , and Kempf V.A.. 2014. Detection of pan drug-resistant Acinetobacter baumannii in Germany. J. Antimicrob. Chemother., 69:2578\u20132579.","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1179\/joc.2007.19.4.462","article-title":"First report of molecular characterization of carbapenem-resistant Acinetobacter baumannii in different intensive care units in University Hospital Split, Croatia","volume":"19","author":"Goic-Barisic I.","year":"2007","unstructured":"Goic-Barisic I., , Bedenic B., , Tonkic M., , Katic S., , Kalenic S., , and Punda-Polic V.. 2007. First report of molecular characterization of carbapenem-resistant Acinetobacter baumannii in different intensive care units in University Hospital Split, Croatia. J. Chemother., 19:462\u2013464.","journal-title":"J. Chemother."},{"key":"e_1_3_4_8_2","doi-asserted-by":"crossref","first-page":"902","DOI":"10.3109\/23744235.2015.1078906","article-title":"Acinetobacter baumannii in Southern Croatia: clonal lineages, biofilm formation, and resistance patterns","volume":"47","author":"Kaliterna V.","year":"2015","unstructured":"Kaliterna V., , Kaliterna M., , Hrenovic J., , Barisic Z., , Tonkic M., , and Goic-Barisic I.. 2015. Acinetobacter baumannii in Southern Croatia: clonal lineages, biofilm formation, and resistance patterns. Infect. Dis., 47:902\u2013907.","journal-title":"Infect. Dis."},{"key":"e_1_3_4_9_2","unstructured":"Public Health Collegium Committee for Antibiotic Resistance Surveillance in Croatia. 2015. Antibiotic Resistance in Croatia 2014. Croatian Academy of Medical Sciences Zagreb."},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2015.0275"},{"key":"e_1_3_4_11_2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2807\/1560-7917.ES.2016.21.15.30195","article-title":"Carbapenem-resistant isolates of Acinetobacter baumannii in a municipal wastewater treatment plant, Croatia, 2014","volume":"21","author":"Hrenovic J.","year":"2016","unstructured":"Hrenovic J., , Goic-Barisic I., , Kazazic S., , Kovacic A., , Ganjto M., , and Tonkic M.. 2016. Carbapenem-resistant isolates of Acinetobacter baumannii in a municipal wastewater treatment plant, Croatia, 2014. Euro Surveill., 21:21\u201330.","journal-title":"Euro Surveill."},{"key":"e_1_3_4_12_2","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.ijmm.2014.04.014","article-title":"MALDI-TOF MS and chemometric based identification of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex species","volume":"304","author":"Sousa C.","year":"2014","unstructured":"Sousa C., , Botelho J., , Silva L., , Grosso F., , Nemec A., , Lopes J., , and Peixe L.. 2014. MALDI-TOF MS and chemometric based identification of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex species. Int. J. Med. Microbiol., 304:669\u2013677.","journal-title":"Int. J. Med. Microbiol."},{"key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1128\/JCM.01026-10","article-title":"Clonal diversity of nosocomial epidemic Acinetobacter baumannii strains isolated in Spain","volume":"49","author":"Villal\u00f3n P.","year":"2011","unstructured":"Villal\u00f3n P., , Valdezate S., , Medina-Pascual M.J., , Rubio V., , Vindel A., , and Saez-Nieto J.A.. 2011. Clonal diversity of nosocomial epidemic Acinetobacter baumannii strains isolated in Spain. J. Clin. Microbiol., 49:875\u2013882.","journal-title":"J. Clin. Microbiol."},{"key":"e_1_3_4_14_2","unstructured":"European Committee on Antimicrobial Susceptibility Testing. 2014. Clinical breakpoint tables. EUCAST Reading guide. Version 4.0."},{"key":"e_1_3_4_15_2","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing: 23rd Informational Supplement, M100-S23","author":"Clinical and Laboratory Standards Institute","year":"2013","unstructured":"Clinical and Laboratory Standards Institute. 2013. Performance Standards for Antimicrobial Susceptibility Testing: 23rd Informational Supplement, M100-S23. Clinical and Laboratory Standards Institute, Wayne."},{"key":"e_1_3_4_16_2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ijantimicag.2006.01.004","article-title":"Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp","volume":"27","author":"Woodford N.","year":"2006","unstructured":"Woodford N., , Ellington M.J., , Coelho J.M., , Turton J.F., , Ward M.E., , Brown S., , Amyes S.G., , and Livermore D.M.. 2006. Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp. Int. J. Antimicrob. Agents., 27:351\u2013353.","journal-title":"Int. J. Antimicrob. Agents."},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03570.x"},{"key":"e_1_3_4_18_2","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jhin.2010.12.003","article-title":"Outbreak in Croatia caused by a new carbapenem-resistant clone of Acinetobacter baumannii producing OXA-72 carbapenemase","volume":"77","author":"Goic-Barisic I.","year":"2011","unstructured":"Goic-Barisic I., , Towner K.J., , Kovacic A., , Sisko-Kraljevic K., , Tonkic M., , Novak A., , and Punda-Polic V.. 2011. Outbreak in Croatia caused by a new carbapenem-resistant clone of Acinetobacter baumannii producing OXA-72 carbapenemase. J. Hosp. Infect., 77:368\u2013369.","journal-title":"J. Hosp. Infect."},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2010.0013"},{"key":"e_1_3_4_20_2","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.ijmm.2015.07.007","article-title":"The transferability of blaOXA-23 gene in multidrug-resistant Acinetobacter baumannii isolates from Saudi Arabia and Egypt","volume":"305","author":"Lopes B.S.","year":"2015","unstructured":"Lopes B.S., , Al-Agamy M.H., , Ismail M.A., , Shibl A.M., , Al-Qahtani A.A., , Al-Ahdal M.N., , and Forbes K.J.. 2015. The transferability of blaOXA-23 gene in multidrug-resistant Acinetobacter baumannii isolates from Saudi Arabia and Egypt. Int. J. Med. Microbiol., 305:581\u2013588.","journal-title":"Int. J. Med. Microbiol."}],"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/mdr.2016.0229","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2016.0229","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/mdr.2016.0229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T20:31:11Z","timestamp":1777667471000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/mdr.2016.0229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1089\/mdr.2016.0229"],"URL":"https:\/\/doi.org\/10.1089\/mdr.2016.0229","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6]]}}}