{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T19:26:59Z","timestamp":1777922819142,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T00:00:00Z","timestamp":1484006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2017,9,1]]},"abstract":"<jats:p>\n                    Currently, echinocandins are first-line drugs for treatment of invasive candidiasis. However, data on how serum influences killing activity of echinocandins against uncommon\n                    <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                    species are limited. Therefore, the killing activity of micafungin in RPMI-1640 and in 50% serum was compared against\n                    <jats:italic toggle=\"yes\">Candida guilliermondii<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Candida lusitaniae<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">Candida kefyr<\/jats:italic>\n                    . Minimum inhibitory concentration (MIC) ranges in RPMI-1640 were 0.5\u20131, 0.12\u20130.25, and 0.06\u20130.12\u2009mg\/L, respectively. In 50% serum, MICs increased 32- to 256-fold. In RPMI-1640\u2009\u2265\u20090.25, \u22654, and 32\u2009mg\/L micafungin was fungicidal against all four\n                    <jats:italic toggle=\"yes\">C. kefyr<\/jats:italic>\n                    (\u22644.04 hours), two of three\n                    <jats:italic toggle=\"yes\">C. lusitaniae<\/jats:italic>\n                    (\u226416.10 hours), and two of three\n                    <jats:italic toggle=\"yes\">C. guilliermondii<\/jats:italic>\n                    (\u226412.30 hours), respectively. In 50% serum, all three species grew at \u22644\u2009mg\/L. Micafungin at 16\u201332\u2009mg\/L was fungicidal against all\n                    <jats:italic toggle=\"yes\">C. kefyr<\/jats:italic>\n                    isolates (\u22643.03 hours) and at 32\u2009mg\/L was fungistatic against one of three\n                    <jats:italic toggle=\"yes\">C. lusitaniae<\/jats:italic>\n                    isolates. Two\n                    <jats:italic toggle=\"yes\">C. lusitaniae<\/jats:italic>\n                    isolates and all three\n                    <jats:italic toggle=\"yes\">C. guilliermondii<\/jats:italic>\n                    grew at all tested concentrations. Adding human serum to susceptibility test media drew attention to loss of fungicidal or fungistatic activity of micafungin in the presence of serum proteins, which is not predicted by MICs in case of\n                    <jats:italic toggle=\"yes\">C. kefyr<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">C. lusitaniae<\/jats:italic>\n                    in RPMI-1640. Our results strongly suggest that micafungin and probably other echinocandins should be used with caution against rare\n                    <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                    species.\n                  <\/jats:p>","DOI":"10.1089\/mdr.2016.0241","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T15:12:16Z","timestamp":1484061136000},"page":"764-770","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Decreased Killing Activity of Micafungin Against\n                    <i>Candida guilliermondii<\/i>\n                    ,\n                    <i>Candida lusitaniae<\/i>\n                    , and\n                    <i>Candida kefyr<\/i>\n                    in the Presence of Human Serum"],"prefix":"10.1177","volume":"23","author":[{"given":"Qasem","family":"Saleh","sequence":"first","affiliation":[{"name":"University of Debrecen","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e1t\u00f3","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"University of Debrecen","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"Kardos","sequence":"additional","affiliation":[{"name":"University of Debrecen","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Gesztelyi","sequence":"additional","affiliation":[{"name":"University of Debrecen","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam\u00e1s","family":"Kardos","sequence":"additional","affiliation":[{"name":"University of Debrecen","place":["Hungary"]},{"name":"University of Debrecen","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliz","family":"Boz\u00f3","sequence":"additional","affiliation":[{"name":"University of Debrecen","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Majoros","sequence":"additional","affiliation":[{"name":"University of Debrecen","place":["Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,1,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2111.150404"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-014-3408-3"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv087"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-014-3400-y"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40588-015-0015-1"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-014-0286-5"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ933"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-013-4761-9"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2012.05.011"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-012-9554-7"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.066381-0"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000116"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks180"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02350-07"},{"key":"e_1_3_2_16_2","unstructured":"Clinical and Laboratory Standards Institute. 2008. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts. Approved Standard. 3rd ed. M27-A3. 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